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Anti-tumor properties of DICKKOPF 3b

A tumor and protein technology, used in anti-tumor drugs, recombinant DNA technology, translation products of oncogenes, etc.

Active Publication Date: 2015-05-27
UNIV OF MASSACHUSETTS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Taking prostate cancer as an example, overexpression of DKK3 halts the proliferation of prostate cancer cells, but a beneficial consequence of DKK3 overexpression in both in vivo and ex vivo models of prostate cancer may be the inadvertent initiation of ER stress in cells Artifacts resulting from attempts to process overexpressed exogenous secreted gene products (Abarzua et al., 2005 Cancer Res 65(21):9617-22; Abarzua et al., 2008 Biochem Biophys Res Commun 375(4):614- 8; Abarzua et al., 2007 Int J Mol Med 20(1):37-43)

Method used

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Embodiment Construction

[0025] The present invention relates to novel therapies for cancer treatment utilizing the tumor suppressor function of DKK3b. More specifically, a novel tumor suppressor was identified that originates from the internal transcription initiation site of the Dkk3 locus and that the gene product possesses all the anticancer properties of this gene. Unlike current therapeutic attempts all directed at the artificial ER stress response caused by exogenous expression of the full-length, secreted, glycosylated DKK3 gene product, the present invention promises a unique approach that changes the direction of the field.

[0026] Unexamined signaling through the Wnt pathway signaling molecule β-catenin is common in cancer, and Dickkopf-related protein 3 (DKK3) is one of the most promising tumor suppressor molecules to control β-catenin levels. Tumor malignancy is inversely correlated with DKK3 levels, and overexpression in almost all cancer cells blocks cell proliferation. Although DKK3 ...

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Abstract

The invention relates to novel therapeutic approaches to cancer treatment that exploits tumor suppressor functions of DKK3b by site-specific delivery of DKK3b. Novel therapeutics and methods for treating tumors and cancers utilizing DKK3b tumor suppressor functions are disclosed.

Description

[0001] Statement Regarding Federally Sponsored Research or Development [0002] The US Government has certain rights in this invention pursuant to NIH Grant Nos. DK038772 and DK060051 to the University of Massachusetts Medical School. [0003] Priority claims and related patent applications [0004] This application claims the benefit of priority to US Provisional Application Serial No. 61 / 615,514, filed March 26, 2012, which is hereby incorporated by reference in its entirety for all purposes. technical field [0005] In general, the present invention relates to the tumor suppressive properties and functions of DKK3b and its anti-tumor applications and uses. More specifically, the present invention relates to novel therapies and methods for treating tumors and cancers utilizing the tumor suppressor function of DKK3b, eg, through site-specific delivery of DKK3b or related agents. Background of the invention [0006] Suppressed Dickkopf-3 (DKK3) expression is a hallmark of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/46C07K14/82C12N5/10C12N15/12C12N15/63A61K38/17A61P35/00
CPCA61K38/00C07K14/82A61K38/55A61P35/00
Inventor 杰克·L·伦纳德黛博拉·M·伦纳德卡尔·J·西敏
Owner UNIV OF MASSACHUSETTS