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Octreotide acetate tablet and preparation method thereof

A technology of octreotide acetate and octreotide tablets, which is applied in the direction of pill delivery, pharmaceutical formulations, and medical preparations of non-active ingredients, can solve the problems of complex liposome preparation process, difficult industrialization, and few products, and achieve The effect of prolonging the drug action time, convenience of medication, and extended shelf life

Inactive Publication Date: 2015-06-03
陈卓杰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the liposome preparation process is complicated, and there are not many products on the domestic market at present, the industrialization is difficult, and low temperature storage is required
Although there have been improvements in the dosage form of octreotide acetate, it is still focused on injection administration

Method used

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  • Octreotide acetate tablet and preparation method thereof
  • Octreotide acetate tablet and preparation method thereof
  • Octreotide acetate tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1 Preparation of octreotide acetate nanoparticles of the present invention

[0022] prescription:

[0023]

[0024] Specific steps are as follows:

[0025] 1) Dissolving octreotide acetate and enzyme inhibitor in purified water to obtain an aqueous phase; in addition, dissolving the polymer material in an organic solvent to obtain an organic phase; placing the organic phase and the aqueous phase in a mixer, and homogenizing at high speed to form double milk;

[0026] 2) spray-drying the double emulsion obtained in step 1) to obtain octreotide acetate nanoparticles.

Embodiment 2

[0027] Example 2 Preparation of Octreotide Acetate Nanoparticles of the Present Invention

[0028] prescription:

[0029]

[0030] The specific steps are the same as those in Example 1.

Embodiment 3

[0031] Example 3 Preparation of Octreotide Acetate Nanoparticles of the Present Invention

[0032] prescription:

[0033] Octreotide acetate 1g

[0034] Orlistat 0.05g

[0035] Polyethylene glycol-polylactic acid copolymer 50g

[0036] The specific steps are the same as those in Example 1.

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PUM

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Abstract

The invention relates to an octreotide acetate tablet and a preparation method thereof. The octreotide acetate tablet is prepared from octreotide acetate nanoparticle and pharmaceutically acceptable tablet auxiliary materials, wherein the octreotide acetate nanoparticle comprises octreotide acetate, an enzyme inhibitor and a high polymer material. The octreotide acetate tablet provided by the invention is capable of significantly prolonging the medicine action time, and is convenient to medicate in comparison with an injection dosage form; the compliance of patients is improved; and meanwhile, the octreotide acetate tablet wraps a high-molecular compound and exists in a solid form, so that the quality guarantee period of the octreotide acetate is significantly prolonged.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to octreotide acetate tablets and a preparation method thereof. Background technique [0002] Octreotide acetate is a synthetic octapeptide compound, which is a tetradeceptide human somatostatin analog. The pharmacological action of octreotide is similar to that of natural hormones, but its inhibitory effect on growth hormone, glucagon and insulin is stronger. Similar to somatostatin, octreotide also inhibits the LH response to GnRH, reduces splanchnic blood flow, and inhibits the secretion of 5-HT, gastrin, vasoactive intestinal peptide, chymotrypsin, motilin, and glucagon. [0003] Because octreotide acetate is a polypeptide preparation, oral absorption of the drug is poor, while subcutaneous and intravenous administration can be rapidly and completely absorbed. Octreotide acetate injection, clinical use can be intravenous injection, subcutaneous injection, intravenous...

Claims

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Application Information

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IPC IPC(8): A61K38/08A61K47/42A61K47/28A61K47/22A61K9/20A61P5/08A61P5/48
Inventor 陈卓杰
Owner 陈卓杰
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