A kind of preparation method of alcalcidol intermediate

Abstract

The present invention relates to a method for enzymatic resolution and preparation of compound 1A, more precisely, the enantiomer separation and recycling method is to first treat compound 1 or 9 with enzymes to obtain compound 1A and compound 7; Selective saponification, oxidation, reduction to obtain compound 1; the obtained compound 1 can enter the cycle of step a-d or a-e again to achieve the purpose of enantiomeric resolution and recycling.

Description

technical field

[0001] The present invention relates to a recovery method for enzymatic resolution and separation of racemic compounds and by-products, in particular to a new method for preparing alcalcitol intermediate 1A. Background technique:

[0002] Vitamin D (vitamin D) is a sterol derivative with anti-rickets effect, also known as anti-rickets vitamin. At present, it is considered that vitamin D is also a steroid hormone, and the most important members of the vitamin D family are VD2 (ergocalciferol) and VD3 (cholecalciferol). Vitamin D is a derivative of different provitamin D after ultraviolet irradiation. A 40-year study by American scientists found that taking a daily dose of vitamin D can cut the risk of breast, colon and ovarian cancer in half. When the sun shines on the skin, the body produces vitamin D, which accounts for 90% of the body's vitamin D supply.

[0003] In recent years, more and more evidence has shown that a lack of vitamin D can be extremely ...

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