Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Pharmaceutical composition containing lorcaserin and medical application of pharmaceutical composition

A technology of lorcaserin and a composition, applied in the field of medicine, can solve the problems of poor continuous weight loss effect, large adverse reactions, etc., and achieve the effects of reducing the risk of medication, preventing the probability of diabetic complications, and maintaining a stable blood sugar concentration

Inactive Publication Date: 2015-06-24
NANJING ANGGU PHARMA TECH
View PDF1 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to overcome the disadvantages of the prior art that lorcaserin has relatively large adverse reactions in the course of obesity treatment and the effect of sustained weight loss is not good, the present invention provides a pharmaceutical composition containing lorcaserin, which is used for It has definite curative effect and less adverse reactions in the treatment of obesity, and also has a good therapeutic effect on metabolic syndrome, and has a good clinical application prospect

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical composition containing lorcaserin and medical application of pharmaceutical composition
  • Pharmaceutical composition containing lorcaserin and medical application of pharmaceutical composition
  • Pharmaceutical composition containing lorcaserin and medical application of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The preparation of embodiment 1 compound tablet

[0018]

[0019] Preparation process: Weigh the prescribed amount of lorcaserin, metformin, starch, and microcrystalline cellulose and mix evenly. In addition, add an appropriate amount of 15% starch slurry to the mixed powder, mix evenly, make soft materials, pass through a 18-mesh nylon sieve to make wet granules, and dry at about 60°C. The moisture content of dry granules should be controlled below 1.5%. Sieve through a 20-mesh sieve, mix with magnesium stearate, and press into tablets.

Embodiment 2

[0020] The preparation of embodiment 2 compound tablet

[0021]

[0022] Preparation process: the preparation method is the same as in Example 1 except that the auxiliary materials are different.

Embodiment 3

[0024] a. Lorcaserin 2g

[0025] Hydroxypropyl Methyl Cellulose-4M 20g

[0026] Microcrystalline Cellulose 10g

[0027] 8% PVP in absolute ethanol solution

[0028] Magnesium Stearate 1.5g

[0029] Preparation process: Pass lorcaserin through a 100-mesh sieve, hydroxypropyl cellulose-4M, and microcrystalline cellulose pass through a 80-mesh sieve, weigh the prescribed amount of lorcaserin, hydroxypropyl cellulose-4M, and microcrystalline cellulose Mix the ingredients evenly, add an appropriate amount of 8% PVP absolute ethanol solution to granulate, dry at 60°C, sieve the dry granules with a 16-mesh sieve, and add the prescribed amount of magnesium stearate to the dry granules.

[0030]b. Metformin 5g

[0031] Sodium Carboxymethyl Cellulose 40g

[0032] Lactose 30g

[0033] 6% PVP in 95% ethanol solution 50g

[0034] Magnesium stearate 2g

[0035] Preparation process: Metformin is passed through a 100-mesh sieve, carboxymethylcellulose sodium and lactose are passed thr...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the field of medicines, and relates to a pharmaceutical composition containing lorcaserin and a medical application of the pharmaceutical composition, in order to overcome the deficiencies in the prior art that lorcaserin has a large adverse reaction in an obesity treatment process, and the effect of continuously losing weight is not good. The pharmaceutical composition has definite treatment effect and small adverse reaction when applied to obesity treatment, and has good therapeutic action on a metabolic syndrome, and good clinical application prospects.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a pharmaceutical composition containing lorcaserin and its medical use, in particular to a pharmaceutical composition with lorcaserin and metformin as active ingredients and its use for treating or preventing obesity Syndrome and the medicinal use of metabolic syndrome. Background technique [0002] Obesity is a common and ancient cluster of metabolic disorders. When the human body eats more calories than it consumes, the excess calories are stored in the body in the form of fat, which exceeds the normal physiological requirements, and when it reaches a certain value, it becomes obesity. Normal adult adipose tissue accounts for 15% to 18% of body weight in males and 20% to 25% in females. With age, the percentage of body fat increases accordingly. Obesity is defined as those whose body weight exceeds the standard body weight by 20% or whose body mass index [BMI=weight (Kg) / (height)2(m2)]...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/55A61P3/06A61P3/04A61P3/10A61P3/00A61K31/155
Inventor 程浩
Owner NANJING ANGGU PHARMA TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com