Method for extracting xanthophyll from Cordyceps militaris

A technology of Cordyceps militaris and lutein, applied in the direction of organic chemistry, can solve the problems of low utilization rate of artificial Cordyceps militaris and low extraction rate of lutein, and achieve suitable large-scale production, optimization of process parameters and extraction conditions, high efficiency The effect of extraction

Active Publication Date: 2015-07-08
河南金家源虫草生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Aiming at the defects of low utilization rate of artificial Cordyceps militaris, low extraction rate of lutein and the functional advantages of ionic liquids in the prior art, the present invention aims to develop a method to extract The combined extraction method of lutein fully meets the general needs in the fields of medicine and chemical industry, and realizes the purpose of large-scale extraction in industry

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1: investigate the kind of ionic liquid

[0035] A. Prepare materials

[0036] Take 1 kg of artificial Cordyceps militaris, wash with water, dry naturally, then pulverize, grind, mix well, pass through a 20-mesh sieve, and collect artificial Cordyceps militaris powder.

[0037] B. Fermentation treatment

[0038] Weighing step A to obtain 100 g of artificial Cordyceps militaris powder and 0.5 g of Angel yeast powder, wherein Angel yeast powder is 0.5% of the weight of artificial Cordyceps militaris powder, dissolved in warm water at 35°C, and fermented for 20 hours at a constant temperature and isolated from the air. Obtain a fermented broth.

[0039] C. Ionic liquid extraction and purification

[0040] Filter the fermentation broth in step B using a filter with a mesh size of 150 mesh, add 800 g of ionic liquid to the filtrate, mix and mix, then add 40 g of extraction aid 18-crown-6, place in ultrasonic Extract in an extraction kettle at 300 W ultrasonic...

Embodiment 2

[0047] Embodiment 2: investigate the kind of extraction aid

[0048] A. Prepare materials

[0049] Take 1 kg of artificial Cordyceps militaris, wash with water, dry naturally, then pulverize, grind, mix well, pass through a 30-mesh sieve, and collect artificial Cordyceps militaris powder.

[0050] 、 Fermentation

[0051] Weighing step A to obtain 100 g of artificial Cordyceps militaris powder and 1 g of Angel yeast powder, wherein the Angel yeast powder is 1% of the weight of the artificial Cordyceps militaris powder, dissolved in warm water at 40°C, and fermented at a constant temperature and isolated from air for 18 hours. Obtain a fermented broth.

[0052] C. Ionic liquid extraction and purification

[0053] The fermented liquid of step B is filtered with a filter screen, the mesh of the filter screen used is 100 mesh, 1000 g of 1-butyl-3-methylimidazolium tetrafluoroborate is added to the filtrate, after mixing and mixing, add 40 g extraction aid, placed in an ultra...

Embodiment 3

[0060] Embodiment 3: investigate the consumption of ionic liquid

[0061] A. Prepare materials

[0062] Take 1 kg of artificial Cordyceps militaris, wash with water, dry naturally, then pulverize, grind, mix well, pass through a 40-mesh sieve, and collect artificial Cordyceps militaris powder.

[0063] 、 Fermentation

[0064] Weighing step A to obtain 100 g of artificial Cordyceps militaris powder and 1.5 g of Angel yeast powder, wherein Angel yeast powder is 1.5% of the weight of artificial Cordyceps militaris powder, dissolved in warm water at 40°C, and fermented for 22 hours at a constant temperature and isolated from the air. Obtain a fermented broth.

[0065] C. Ionic liquid extraction and purification

[0066] Filter the fermentation broth in step B using a filter with a mesh size of 150 mesh, add ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate to the filtrate, mix well, and then add extraction Auxiliary agent 18-crown-6, in which the amount of extracti...

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Abstract

The invention relates to an efficient method for extracting lutein from Cordyceps militaris, which comprises the following steps: preparing raw materials, performing fermentation treatment, performing ionic liquid extraction and purifying. By performing optimal combination on the extraction process and creatively adopting an ionic liquid / assistant composite extraction manner, the method achieves the purpose of efficiently extracting lutein from Cordyceps militaris, obtains the technical effect that the extraction rate is far higher than that in the prior art, greatly increases the utilization ratio of the raw materials, and avoids the consumption of a large amount of organic solvent. Thus, the method has the advantages of being green, environment-friendly and suitable for large-scale production, and has an application prospect of being widely industrialized.

Description

technical field [0001] The invention belongs to the technical field of extracting active ingredients of medicines from natural plants. More specifically, the present invention relates to a high-efficiency method for extracting lutein from Cordyceps militaris. Background technique [0002] Lutein, also known as "plant lutein", is an excellent antioxidant and the only carotenoid that can exist in the lens of the eye. It can be used to prevent vision loss or blindness caused by age-related macular degeneration , and prevent cardiovascular sclerosis, coronary heart disease and tumor diseases caused by body aging. [0003] In nature, lutein and zeaxanthin coexist and are the main components of plant pigments such as corn, vegetables, fruits, and flowers. Based on its excellent oxidation resistance, it is expensive and is called "natural gold". Therefore, since the mid-1980s, researchers began to pay attention to various physiological functions of lutein, as well as artificial ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C403/24
Inventor 司红康李耀亭范远景史成龙盛新颖
Owner 河南金家源虫草生物科技有限公司
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