Application of dark plum fruit and extract of dark plum fruit in preparation of drug or health care product for controlling CRC (colorectal cancer)
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A technology of health care products and extracts, applied in the field of medicine, to achieve the effects of improving weight loss, taking convenience, and reducing the incidence of colon tumors
Active Publication Date: 2015-07-29
JIANGSU PROVINCIAL HOSPITAL OF TCM
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[0003] At present, the drugs used for the treatment of CRC mainly include oxaliplatin, fluorouracil, irinotecan, folic acid and bevacizumab, etc. However, the five-year survival rate after radical resection of CRC is still hovering around 50%, and it is even less than 30% in the advanced stage. %
However, there is no relevant report on the use of ebony extract in the preparation of drugs for the prevention and treatment of intestinal disease carcinogenesis.
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Embodiment 1
[0023] The preparation method of the ebony extract: take the dried ebony medicinal material, add water and steam for 2-3 times, each time for 1-3 hours. Add 5-15 times the amount of water for the first time, filter, add 5-15 times the amount of water for the second time, filter, add 5-10 times the amount of water for the third time, and filter. The three filtrates were combined, centrifuged (3000rpm) for 15 minutes, and the supernatant was separated, and the concentration was adjusted to 1 g medicinal material / ml in a water bath at 60 ° C, or dried under reduced pressure to form a dry extract.
Embodiment 2
[0024] Example 2 Study on the preventive and therapeutic effects of ebony extract on AOM-DSS-induced mouse colon tumors.
[0025] 1. Experimental materials
[0026] 1.1 Experimental drugs and reagents
[0027] Black plum extract: the black plum extract prepared in Example 1 of the present invention; Azoxymethane (AOM) was purchased from sigma company, batch number: SLBD6763V; dextran sodium sulfate (dextran sodium sulfate, DSS) was purchased from Mpbio Company, lot number: M8667.
[0028] 1.2 Experimental animals and breeding
[0029] C57 mice, 18-22g, male, provided by the Comparative Medicine Center of Yangzhou University, certificate number: SCXK (Su) 2012-0004. Full-price nutritional pellet feed: provided by Jiangsu Synergy Pharmaceutical Biotechnology Co., Ltd. Breeding conditions: room temperature 20±2°C, humidity 55–65%, alternating light and dark, moderate light, good ventilation and cleanliness.
[0030] 2. Method
[0031] 2.1 AOM-DSS-induced inflammatory bowel ...
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Abstract
The invention discloses an application of dark plum fruit and an extract of dark plum fruit in control of the CRC (colorectal cancer). On the basis of the conventional efficacy of dark plum fruit, a large quantity of experiments is adopted for intensive study, an AOM-DSS (azoxymethane/dextran sodium sulfate) induced mouse model suffering from bowel disease carcinogenesis is adopted, and study results show that the dark plum fruit and the extract of the dark plum fruit can substantially improve the condition of weight loss of the model mouse in a bowel disease carcinogenesis process, can substantially improve the continuously serious symptoms such as body mass loss, loose stools, hematochezia and the like of the mouse suffering from bowel disease carcinogenesis, can substantially reduce the colonic neoplasm incidence of the mouse suffering from bowel disease carcinogenesis and has very good CRC preventing and controlling efficacy.
Description
technical field [0001] The invention relates to a traditional Chinese medicine, in particular to the new application of ebony plum and its extract in the preparation of medicines for preventing and treating intestinal cancer, and belongs to the technical field of medicine. Background technique [0002] Colorectal cancer (CRC), also known as colorectal cancer, is one of the most common malignant tumors. More than one million people worldwide suffer from colorectal cancer every year and cause about 50 million deaths, accounting for the largest proportion of malignant tumors in the world. Death ranks fourth. At present, the incidence of colorectal cancer in my country is on the rise, and the domestic incidence rate is about 4.8%, far exceeding the international level of 2%. [0003] At present, the drugs used for the treatment of CRC mainly include oxaliplatin, fluorouracil, irinotecan, folic acid and bevacizumab, etc. However, the five-year survival rate after radical resection...
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