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Drug for intervention treatment of diabetic peripheral neuropathy (DPN)

A technology for peripheral neuropathy and diabetes, applied in nervous system diseases, drug combinations, metabolic diseases, etc., can solve the problems of elevated blood sugar, tooth damage, spleen and stomach damage in diabetic patients

Inactive Publication Date: 2015-08-12
NINGBO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Although it has been shown in the above prior art that chicken zi huang and dried rehmannia may have hypoglycemic effects respectively, the prior art does not provide a method for using chicken zi huang and dried rehmannia
Especially because chicken yellow is rich in fructose, if the mechanism and specific active ingredients are not clear, the rich fructose will cause a sharp increase in blood sugar of diabetic patients, which is not conducive to the health of patients
Furthermore, Dried Rehmannia glutinosa is rich in citric acid, malic acid, and succinic acid. Eating too much will not only damage the teeth, but also damage the spleen and stomach.

Method used

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  • Drug for intervention treatment of diabetic peripheral neuropathy (DPN)
  • Drug for intervention treatment of diabetic peripheral neuropathy (DPN)
  • Drug for intervention treatment of diabetic peripheral neuropathy (DPN)

Examples

Experimental program
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Effect test

preparation example Construction

[0026] 2. Preparation of Compositions

[0027] The aforementioned volatile oils separated and collected from chicken zi huang and dried rehmannia glutinosa are mixed according to a specific ratio to prepare the stock solution of the composition. According to different clinical needs, it can be made into pills, powders, tablets, suppositories, granules, films, capsules, microcapsules, dropping pills, aerosols, injections, ointments, liquors, syrups, oral Solution, gel or liposome. The specific implementation method can be carried out according to the standard of Chinese Pharmacopoeia 2000 edition.

[0028] 3. The effect detection of composition of the present invention

[0029] 3.1 Animal source and model preparation

[0030]Healthy male SD rats, aged 2 months and weighing 150-200 g, were provided by the Experimental Animal Center of Zhejiang Province. Before the experiment, the animals were placed in the laboratory to adapt to the environment for a week, free to drink wate...

Embodiment

[0054] The fresh fruit (or frozen fresh) of 1000g Jizihuang and dried Rehmannia glutinosa is pulverized and homogenized with a blender, and placed in such as figure 1 In the shown retort, the distillation product is collected after distillation. Wherein the distilled product of Jizihuang is 643g, and the yield is 64.3%, and the distilled product of dry rehmannia glutinosa is 427g, and the yield is 42.7%.

[0055] The above-mentioned distillation products were formulated in different proportions, and fed to model rats and normal rats as controls. The specific experimental examples and comparative examples are shown in Table 1. After the four-week feeding experiment, the blood index detection values ​​of the rats in each group were counted, and the concentration of serum glucose (in mg / dl) was measured by the glucose oxidase method.

[0056] figure 2 Shown is the result of a typical experimental example of the composition of the present invention, and each experimental group ...

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Abstract

The invention discloses a drug for the intervention treatment of diabetic peripheral neuropathy (DPN). The drug comprises the following effective components in percentage by weight: 45 to 80% of chicken egg yolk, and 5 to 15% of dried rehmannia root. The results of animal experiments show that the provided drug can effectively reduce the blood sugar level of diabetic rats, moreover, the area under the curve (AUC) in the glucose tolerance tests is reduced, and the DPN pain index of diabetic rates is also reduced.

Description

technical field [0001] The invention relates to a medicament for intervening and treating diabetic peripheral neuropathy pain, in particular to a medicament for intervening and treating diabetic peripheral neuropathy, which contains chicken yellow and dried rehmannia glutinosa as active ingredients. Background technique [0002] Diabetes (diabetes) is a series of metabolic disorder syndromes of sugar, protein, fat, water and electrolytes caused by a variety of pathogenic factors acting on the body leading to hypofunction of islets and insulin resistance. Clinically, it is characterized by hyperglycemia. The overall prevalence of diabetes in my country has reached 9.7%. The prevalence of prediabetes during the same period was as high as 15.5%. According to the calculations made based on the survey results, the total number of people with diabetes in my country is more than 92 million, and the number of people with pre-diabetes is more than 148 million. Diabetes is the absol...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61P25/02A61P3/10A61K35/54
Inventor 罗琳周文华赵明陈争跃
Owner NINGBO UNIV
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