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Cefquinome sulfate uterine injectant for milk cows and preparation method of cefquinome sulfate uterine injectant

A technology of cefquinoxime sulfate and cefquinoxime, which is applied in the field of cefquinome sulfate uterine injection and preparation thereof, can solve the problems such as being difficult to reach the inside of the uterus, and achieve easy scaled production, good stability and convenient administration. quick effect

Active Publication Date: 2015-08-19
FEED RESEARCH INSTITUTE CHINESE ACADEMY OF AGRICULTURAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The existing cefquinome sulfate injection and powder injection are mainly administered through intramuscular injection, which is difficult to reach the inside of the uterus, and the effect is not as good as local administration of the uterus

Method used

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  • Cefquinome sulfate uterine injectant for milk cows and preparation method of cefquinome sulfate uterine injectant
  • Cefquinome sulfate uterine injectant for milk cows and preparation method of cefquinome sulfate uterine injectant
  • Cefquinome sulfate uterine injectant for milk cows and preparation method of cefquinome sulfate uterine injectant

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preparation example Construction

[0027] Cefquinome sulfate uterine injection provided by the invention is a uniformly distributed preparation, and the specific preparation method comprises the following steps:

[0028] A. Let the vegetable oil (such as neutral soybean oil) cool after filtration and heat sterilization;

[0029] B. Take an appropriate amount of pretreated vegetable oil and add 0.125-1.25g of glyceryl monostearate;

[0030] C. Heat at 60-80°C for 15-30 minutes, wait for the glyceryl stearate to melt, stir evenly, cool to about 40°C, add 0.125-1.25g of suspending agent (such as Span 80), 0.5-2.5 g (in terms of cefquinome) of cefquinome sulfate (5-10 μm in particle size), then add vegetable oil to a total amount of 25ml;

[0031] D. grind evenly, make cefquinome sulfate uterine injection;

[0032] F. Put the medicine into the injection tube, seal it, sterilize it, inspect it with light, and pack it.

[0033] In the following examples, the detection method of the sedimentation particle size of t...

Embodiment 1

[0036] Embodiment 1, the prescription screening of cefquinome sulfate uterine injection

[0037] 1. Screening of glyceryl monostearate content in the formula (note: glyceryl monostearate in the table is referred to as glyceride)

[0038] Table 1

[0039]

[0040] The preparation method is as follows:

[0041] 1) Cefquinoxime sulfate aseptic powder is obtained through ultrafine pulverization to obtain cefquinoxime sulfate aseptic micropowder (particle diameter 5-10 μ m);

[0042] 2) After the soybean oil is filtered and heat sterilized (sterilized at 150° C. for 3 hours), it is placed at room temperature for use;

[0043] 3) Take an appropriate amount of pretreated soybean oil, add glyceryl stearate and suspending agent Span 80; heat and stir (heating at 80°C for 15 minutes), after the glyceryl stearate melts, add cefquinone sulfate Oxime;

[0044] 5) Grind evenly in a sterile colloid mill to prepare cefquinome sulfate uterine injection.

[0045] As can be seen from tab...

Embodiment 2

[0051] Embodiment 2, preparation cefquinome sulfate uterine injection

[0052]

[0053] The preparation method is as follows:

[0054] 1) the aseptic powder of cefquinoxime sulfate is ultrafinely pulverized to obtain the aseptic micropowder of cefquinoxime sulfate with a particle size of 5-10 μm;

[0055] 2) After the soybean oil is filtered and heat sterilized (sterilized at 150° C. for 3 hours), it is placed at room temperature for use;

[0056] 3) Take an appropriate amount of pretreated soybean oil (40%-60% of the total amount of soybean oil), add glyceryl monostearate; heat and stir (heating at 80°C for 15 minutes), wait for glyceryl monostearate Melt the ester, stir evenly, cool to 40°C, add Span 80, cefquinome sulfate, and add soybean oil to the full amount;

[0057] 4) Grind evenly in a sterile colloid mill to prepare cefquinome sulfate uterine injection.

[0058] The properties of the obtained cefquinome sulfate uterine injection are off-white to light yellow oi...

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Abstract

The invention discloses a cefquinome sulfate uterine injectant for milk cows and a preparation method of the cefquinome sulfate uterine injectant. The cefquinome sulfate uterine injectant for milk cows is prepared from the following raw materials and auxiliary materials: 0.5-2.5g of cefquinome sulfate (measured by cefquinome), 0.125-1.25g of glycerin monostearate, 0.125-1.25g of a suspending agent and the balance of vegetable oil added to be up to 25ml. The preparation method comprises the following steps of weighing a proper amount of pretreated vegetable oil, adding glycerin monostearate, and melting by heating; then, adding the suspending agent and cefquinome sulfate; next, adding the vegetable oil to be up to the total quantity; and uniformly grinding to obtain the cefquinome sulfate uterine injectant. The uterine injectant has the following advantages that a drug is slowly released, the bioavailability is high, and the irritation to local tissues is little; due to the adoption of the local drug delivery of the uterus, effects are rapidly taken, and the animal stress response caused by drug delivery by injection is avoided; and the drug is rapidly eliminated, the milk withdrawal period is short, the economic loss is effectively avoided, and the clinical popularization value is very high.

Description

technical field [0001] The invention relates to a cefquinome sulfate uterine injection and a preparation method thereof. Background technique [0002] Cow uterine (endometrium) inflammation is a common and frequently-occurring disease in the dairy farming industry. It is mostly concentrated within 2 weeks after delivery. The general incidence rate is 20% to 35%. It is usually mucous or purulent inflammation of the uterine mucosa. Because the toxic substances produced by inflammation can kill sperm and embryos, it becomes one of the common reasons for dairy cow infertility. In my country, dairy cow uterine (endometrium) inflammatory infertility accounts for more than 17% of adult cow infertility. Uteritis (endometritis) can not only affect the estrus and pregnancy of dairy cows, reduce the milk production of dairy cows, induce mastitis and other diseases, but also cause the loss of reproductive ability of dairy cows in severe cases, and some acutely ill cows can also cause se...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/546A61P15/00
Inventor 李秀波刘义明徐飞张道康刘茂林黄慧丽
Owner FEED RESEARCH INSTITUTE CHINESE ACADEMY OF AGRICULTURAL SCIENCES
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