Peptide drugs for the prevention and treatment of diabetes and its chronic complications

A technology for people with diabetes, medicine, applied in the field of medicine

Active Publication Date: 2018-04-27
ZHUKANG BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, whether C-peptide plays a therapeutic role in diabetes and its chronic complications, and the C-peptide fragment with the best therapeutic effect has not been reported before.

Method used

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  • Peptide drugs for the prevention and treatment of diabetes and its chronic complications
  • Peptide drugs for the prevention and treatment of diabetes and its chronic complications
  • Peptide drugs for the prevention and treatment of diabetes and its chronic complications

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The peptide drug used in the prevention and treatment of diabetes and its chronic complications in this example is in the form of injection, wherein the main drug is the amino terminal fragment of proinsulin C-peptide (as shown in SEQ ID NO. Synthesized by Biotechnology Co., Ltd., the auxiliary material is water for injection, and the mass percentage content of the main drug in peptide drugs is 98.2%.

[0030] The preparation of the injection is a prior art and will not be repeated here.

Embodiment 2

[0032] In this example, the peptide drug used to prevent and treat diabetes and its chronic complications is in the form of injection, wherein the main drug is the pharmaceutically acceptable sodium salt of the amino-terminal fragment of C-peptide (as shown in SEQ ID NO.1) , the auxiliary material is water for injection, and the mass percentage content of the main drug in the peptide drug is 98.2%. The preparation method is the same as in Example 1.

Embodiment 3

[0034] In this example, the peptide drug used to prevent and treat diabetes and its chronic complications is in the form of an injection, and the main drug is a sugar that prolongs the half-life of the amino terminal fragment of the C-peptide (as shown in SEQ ID NO.1) and enhances the curative effect. base modification, the auxiliary material is water for injection, and the mass percentage content of the main drug in the peptide drug is 98.2%. The preparation method is the same as in Example 1.

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Abstract

The invention discloses a peptide drug for preventing and treating diabetes and its chronic complications, belonging to the technical field of medicine. The present invention utilizes streptozotocin (STZ) to induce a diabetic rat model, and uses proinsulin C-peptide amino-terminal fragments to subcutaneously inject to observe its therapeutic effect on rat diabetes and its chronic complications. The results show that C-peptide amino The terminal fragment can inhibit the weight loss of rats, reduce blood sugar and urine protein, and improve the pathological changes of chronic kidney, great blood vessels, heart and pancreatic islets in rats. The present invention uses proinsulin C-peptide N-terminal fragments and / or pharmaceutically acceptable salts thereof, and / or modifications and allomers that prolong the half-life of C-peptide N-terminal fragments and enhance curative effect as pharmaceutical active ingredients, together with conventional excipients Combined to make peptide drugs, it can alleviate diseases such as weight loss, blood sugar and urine protein increase caused by diabetes and its chronic complications.

Description

technical field [0001] The invention relates to a peptide drug for preventing and treating diabetes and its chronic complications, belonging to the technical field of medicine. Background technique [0002] Currently, 382 million people worldwide suffer from DM, and it is expected to reach 592 million by 2035. Nearly 100 million people in my country suffer from DM, accounting for about a quarter of the global population, and the prevalence rate ranks first in the world. The main harm of diabetes is various chronic complications, whether it is type I or type II diabetes, chronic complications are one of the main causes of death. [0003] The C-peptide is the connecting peptide between the A chain and the B chain of insulin, and consists of 31 amino acid residues: EAEDLQVGQVELGGGPGAGS LQPLALEGSL Q (as shown in SEQ ID NO.2). C-peptide is mainly degraded by the kidneys, with a slow clearance rate and a half-life of 20 minutes. The average serum level is 0.4nmol / L. For a long ...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): A61K38/28A61P3/10
Inventor齐锦生栗彦宁何堃宇刘祎萌贺知
OwnerZHUKANG BIOTECHNOLOGY CO LTD