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Peptide drug for prevention and treatment of diabetes and chronic complication thereof

A technology for complications, diabetes, applied in the field of peptide drugs

Active Publication Date: 2015-09-09
ZHUKANG BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, whether C-peptide plays a therapeutic role in diabetes and its chronic complications, and the C-peptide fragment with the best therapeutic effect has not been reported before.

Method used

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  • Peptide drug for prevention and treatment of diabetes and chronic complication thereof
  • Peptide drug for prevention and treatment of diabetes and chronic complication thereof
  • Peptide drug for prevention and treatment of diabetes and chronic complication thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The peptide drug used in the prevention and treatment of diabetes and its chronic complications in this example is in the form of injection, wherein the main drug is the amino terminal fragment of proinsulin C-peptide (as shown in SEQ ID NO. Synthesized by Biotechnology Co., Ltd., the auxiliary material is water for injection, and the mass percentage content of the main drug in peptide drugs is 98.2%.

[0030] The preparation of the injection is a prior art and will not be repeated here.

Embodiment 2

[0032] In this example, the peptide drug used to prevent and treat diabetes and its chronic complications is in the form of injection, wherein the main drug is the pharmaceutically acceptable sodium salt of the amino-terminal fragment of C-peptide (as shown in SEQ ID NO.1) , the auxiliary material is water for injection, and the mass percentage content of the main drug in the peptide drug is 98.2%. The preparation method is the same as in Example 1.

Embodiment 3

[0034] In this example, the peptide drug used to prevent and treat diabetes and its chronic complications is in the form of an injection, and the main drug is a sugar that prolongs the half-life of the amino terminal fragment of the C-peptide (as shown in SEQ ID NO.1) and enhances the curative effect. base modification, the auxiliary material is water for injection, and the mass percentage content of the main drug in the peptide drug is 98.2%. The preparation method is the same as in Example 1.

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Abstract

The invention discloses a peptide drug for the prevention and treatment of diabetes and chronic complication thereof and belongs to the technical field of medicines. The STZ (streptozocin) is utilized for inducing diabetic rats, the treatment effect on the rat diabetes and chronic complication thereof can be observed through insulin original C-peptide amino-terminal fragment thesubcutaneous, according to the result, the C-peptide amino-terminal fragment is capable of inhibiting rat weight decrease, reducing blood sugar and urine protein and optimizing rat chronic kidney, large blood vessel, heart and pancreatic island pathology function change. The insulin original C-peptide amino-terminal fragment and / or pharmaceutically acceptable salt thereof and / or modification and allosteric ligand which prolongs the half-life period of the insulin original C-peptide amino-terminal fragment and which enhances the curative effect are adopted and are combined with conventional auxiliary material for preparing the peptide drug, and the weight loss and blood sugar and urine protein elevation due to the diabetes and the chronic complication thereof can be relieved.

Description

technical field [0001] The invention relates to a peptide drug for preventing and treating diabetes and its chronic complications, belonging to the technical field of medicine. Background technique [0002] Currently, 382 million people worldwide suffer from DM, and it is expected to reach 592 million by 2035. Nearly 100 million people in my country suffer from DM, accounting for about a quarter of the global population, and the prevalence rate ranks first in the world. The main harm of diabetes is various chronic complications, whether it is type I or type II diabetes, chronic complications are one of the main causes of death. [0003] The C-peptide is the connecting peptide between the A chain and the B chain of insulin, consisting of 31 amino acid residues: EAEDLQVGQV ELGGGPGAGS LQPLALEGSL Q (as shown in SEQ ID NO.2). C-peptide is mainly degraded by the kidneys, with a slow clearance rate and a half-life of 20 minutes. The average serum level is 0.4nmol / L. For a long t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/28A61P3/10
Inventor 齐锦生栗彦宁王秀娟刘昆李彬
Owner ZHUKANG BIOTECHNOLOGY CO LTD
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