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Method for predicting the onset of extrapyramidal symptoms (EPS) induced by an antipsychotic-based treatment

An antipsychotic, extrapyramidal technology, used in biochemical devices and methods, drug combinations, neurological diseases, etc.

Active Publication Date: 2015-09-23
UNIV DE BARCELONA +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, neither the rs3803300 SNP nor the haplotype showed any association with the onset of EPS

Method used

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  • Method for predicting the onset of extrapyramidal symptoms (EPS) induced by an antipsychotic-based treatment
  • Method for predicting the onset of extrapyramidal symptoms (EPS) induced by an antipsychotic-based treatment
  • Method for predicting the onset of extrapyramidal symptoms (EPS) induced by an antipsychotic-based treatment

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Experimental program
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Embodiment

[0135] Materials and methods

[0136] subjects

[0137] Sample size calculations assumed a 5% significance level, 80% power and an EPS risk (odds ratio) of 2 associated with carrying the studied allele (allele frequency >0.1). Quanto1.2 software (http: / / hydra.usc.edu / gxe) was used for calculation.

[0138] During a three-year period (2002-2004), a cohort of 321 inpatient psychiatric patients receiving antipsychotic drug therapy was sequentially recruited at the Psychiatry Service of the Hospital Clínic (Barcelona, ​​Spain). 241 subjects from this cohort participated in the pharmacogenetic study of EPS presented here. Subjects diagnosed according to DSM-IV criteria: 184 subjects diagnosed with schizophrenia (n=125) and related disorders (n=22 schizoaffective disorder; n=27 acute psychotic disorder; n=9 delusions psychotic disorder; n=1 schizoid personality disorder); 40 were diagnosed with bipolar disorder; and 17 had other diagnoses (including personality disorder, psycho...

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Abstract

The invention relates to methods for predicting the onset of extrapyramidal symptoms (EPS) induced by an antipsychotic-based treatment as well as methods for providing personalized medicine to patients based on the sequence of several SNPs associated with the onset of EPS. The invention relates as well to kits for carrying out the diagnostic and predictive medicine methods.

Description

field of invention [0001] The present invention relates to methods for predicting the onset of extrapyramidal symptoms (EPS) induced by antipsychotic drug-based treatments and methods for providing personalized medicine to patients. The invention also relates to kits for performing diagnostic and predictive medical methods. Background of the invention [0002] Antipsychotic drug treatment-induced extrapyramidal symptoms (EPS) are frequent and severe acute adverse reactions of antipsychotic drugs, the signs of which can develop within days of starting drug treatment. EPS is a complex phenotype that includes several recognized syndromes, namely parkinsonism, akathisia, acute dystonia, and dyskinesia. Although the situation has improved since the pre-clozapine era, the EPS problem has by no means disappeared; for example, in CATIE (Compared Effectiveness of Antipsychotic Therapies in Patients with Schizophrenia)—a large efficacy trial, 10.5 % of patients discontinued their as...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68
CPCC12Q2600/156C12Q2600/106C12Q1/6883A61P25/02A61P25/16A61P25/18A61P43/00
Inventor S·马斯赫雷罗P·咖搜阿斯托尔加C·马拉格拉达格劳M·伯纳多阿罗约A·拉福恩特弗洛
Owner UNIV DE BARCELONA
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