One pot synthetic method of 2,4-dichloro-3-nitro-5-fluoro-benzoic acid

A technology of fluorobenzoic acid and synthetic method, applied in two fields, can solve the problems of cumbersome operation, many steps, difficult starting raw materials, etc., and achieve the effect of high product yield and simple process
CN104945264AInactive Publication Date: 2015-09-30徐玲琍
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
徐玲琍
Publication Date
2015-09-30
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a one pot synthetic method of 2,4-dichloro-3-nitro-5-fluoro-benzoic acid. The synthetic method takes 2,4-dichloro-3-nitro-5-fluoro-acetophenone as a raw reaction material and comprises the steps of nitration, oxidation and ice melting under the participation of nitric acid to obtain the target product. The one pot synthetic method is simple in process, easy to operate, and as high as 92 percent in product yield.
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Description

technical field

[0001] The invention relates to a one-pot method for synthesizing 2,4-dichloro-3-nitro-5-fluorobenzoic acid. Background technique

[0002] 2,4-Dichloro-3-nitro-5-fluorobenzoic acid is a very critical fine chemical and pharmaceutical intermediate, mainly used in the synthesis of quinolones and floxacins. The new quinolone antibacterial drugs listed in the 1990s include sparfloxacin, nafloxacin, levofloxacin, gepafloxacin, trovafloxacin, and alafloxacin. Among them, levofloxacin has been widely used due to its high efficiency, broad-spectrum, safety and other characteristics since it was launched on the market, and has become one of the most commonly used antibacterial drugs in clinical practice.

[0003] In the late 1990s, some new varieties came out, including gatifloxacin, moxifloxacin, gemifloxacin, etc., and have entered the stage of clinical trials one after another, and some products have been officially applied in clinical practice. Because these prod...

Claims

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