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Oroxylum indicum general flavone extraction and purification method and application thereof

A purification method and wood butterfly technology, applied in the fields of chemistry and medicine, can solve problems that have not yet been reported, and achieve the effect of enhancing drug efficacy and expanding the scope of application

Inactive Publication Date: 2015-10-07
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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AI Technical Summary

Problems solved by technology

Flavonoids are the main active ingredients of the medicinal material of Orchid Butterfly, but the research on the anti-hepatic cancer of the total flavonoids of Orchard Butterfly has not been reported so far.

Method used

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  • Oroxylum indicum general flavone extraction and purification method and application thereof
  • Oroxylum indicum general flavone extraction and purification method and application thereof
  • Oroxylum indicum general flavone extraction and purification method and application thereof

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Embodiment Construction

[0034] The present invention will be further described in detail below in conjunction with specific examples.

[0035] 1. Research on the extraction process of total flavonoids from Orchid oleifera.

[0036] 1.1 Orthogonal experimental design.

[0037] Select ethanol concentration A, extraction time B, solvent usage (material ratio) C, and extraction times D as the investigation factors, select three levels for each factor, and use L 9 (3 4 ) to design an orthogonal experiment and optimize the optimal extraction conditions. The weighted comprehensive score is used to determine the best extraction process of total flavonoids of Orchid Butterfly with the content of total flavonoids in Orchid Butterfly as the main index (weight coefficient is 0.6), and the cream yield (weight coefficient is 0.4) as the secondary index, that is, the comprehensive score is used as the investigation index. Orthogonal test L 9 (3 4 ) factor level table in Table 1, the design table of the orthogo...

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Abstract

The invention relates to an oroxylum indicum general flavone extraction and purification method. Ethyl alcohol backflow and macroporous resin adsorption are used for separating, extracting and purifying oroxylum indicum general flavone, non-flavonoid impurities are removed as many as possible, and finally enrichment is carried out to obtain the high-purity general flavone. The oroxylum indicum general flavone comprises five chemical components including semen oroxyli glycoside B, semen oroxyli glycoside A, chrysin-7-O-beta-D-glucuronide, baicalein and chrysin. The invention further provides application of the oroxylum indicum general flavone to prepating medicine for treating liver cancers. In-vitro pharmacological tests show that the general flavone has the obvious restraining effect on proliferation of liver cancer cells and trends to have the obvious dose-effect relationship, and meanwhile the pharmacological effect is obviously improved along with increase of the purity of the general flavone; in addition, oroxylum indicum general flavone matter analysis studying is carried out, the material basis of oroxylum indicum for playing a role in anti-cancer pharmacological effect is defined, and the material basis and the experiment basis are laid for developing clinical application of oroxylum indicum general flavone enrichment matter, anti-cancer new medicine researching and development and industrial production.

Description

technical field [0001] The invention relates to the technical fields of chemistry and medicine, in particular to a method for extracting and purifying total flavonoids of the Chinese medicinal material Orchid chinensis and its application. Background technique [0002] Liver cancer is one of the most common malignant tumors in the world, and the morbidity and mortality of liver cancer in my country ranks second among tumors. Because of its insidious onset and rapid progression, most of the patients are in the middle and late stages when they are discovered. Therefore, the effect of surgical treatment is poor, and radiotherapy and chemotherapy have obvious adverse reactions, resulting in poor quality of life and short survival period for patients with liver cancer. The comprehensive treatment based on traditional Chinese medicine is of great significance in controlling the disease progression of liver cancer patients, improving the quality of life and prolonging the survival ...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P35/00
Inventor 孟宪生李楠楠杨玉包永睿王帅
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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