Compounds in stemmed pyrrosia petiolosa as well as separation and purification method and application thereof
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A technique for separation and purification of podophyllum, which is applied in the field of pharmacy and can solve the problems of preventing and treating diuretic and drenching stranguria with no chemical components.
Active Publication Date: 2020-09-18
贵州中医药大学
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[0004]
Research by He Zhanju, He Jiayang, Hou Beiping found that clearing away heat, purging fire, diuresis and treating stranguria; Guo Meizhu et al. found that Qingli Xingqi Decoction can be used to prevent and treat urolithiasis; literature shows that these are common prescriptions of traditional Chinese medicine for preventing and treating diuresis and treating stranguria. See the basic research report on the prevention and treatment of diuresis and Tonglin based on the chemical components developed by traditional Chinese medicine and ethnic medicine prescriptions; at present, among most prescriptions, Shiwei-related preparations are the most common for "diuresis and Tonglin", and Shiwei is used as the main raw material in the market There are many varieties of Chinese patent medicines, such as compound Shiwei tablets, compound Shiwei granules, compound Shiwei capsules and other preparations
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Embodiment 1
[0073] The structural formula of embodiment 1 compound
[0074] 1) The structural formula of Baba acid is:
[0075]
[0076] 2) The structural formula of kaempferol is:
[0077]
[0078] 3) The structural formula of methyl chlorogenic acid is:
[0079]
[0080] 4) The structural formula of Petiolide A(1) is:
[0081]
Embodiment 2
[0082] The crystal structure of embodiment 2 babamic acid
[0083]
Embodiment 3
[0084] Example 3 Baba acid characteristics
[0085] White powder, easily soluble in dichloromethane, ethyl acetate, methanol, pyridine, insoluble in petroleum ether, developed with petroleum ether-ethyl acetate at a ratio of 3:1, TLC has a blue color under the detection of wavelength 365nm Fluorescence, heating with 10% sulfuric acid-ethanol solution to develop color, showing purple spots, and Rf=0.56, carbon spectrum, mass spectrum data obtained molecular formula C 19 h 20 o 7 , ESI-MS m / z:360[M] + ,exist 13 In C-NMR (100MHz, DMSO-d6), δ173.25, 168.67 are two carbonyl carbon signals, and δ55.82 (OCH3) is a methoxy carbon signal, 1 H-NMR (400MHz, DMSO-d 6): δ10.73 (1H, s, COOH), δ6.70 (1H, s, H-5′), 6.60 (1H, s, H-5), 3.86 (3H, s, OMe-4), 2.56 (3H, s, Me-8′), 2.48(3H, s, Me-8), 2.00(3H, s, Me-9′), 1.99(3H, s, Me-9); the crystal data are as follows: Molecular formula is C 20 h 24 o 8 , the submass is 392, the crystal system is triclinic, and the total number of unit c...
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Abstract
The invention relates to compounds in stemmed pyrrosia petiolosa as well as a separation and purification method and application thereof. The compounds are barbatic acid, kaempferol, methyl chlorogenate and Petiolide A (1). According to the method disclosed by the invention, the chemical components of the pyrrosia petiolosa are deeply and systematically researched by adopting a modern extraction and separation technology, and metabonomics, drug aided design and drug effect tracking and screening are combined, so that the material basis of diuresis inducing and stranguria treating of the pyrrosia is preliminarily defined, and a foundation is laid for developing diuresis inducing and stranguria treating drugs.
Description
technical field [0001] The present invention relates to the field of pharmacy, in particular to a compound in pisvir and its separation and purification method and application. Background technique [0002] Diuresis and stranguria syndrome belong to the category of "low back pain" and "sprain syndrome" in Chinese medicine, and are common and frequently-occurring diseases of the urinary system, with a high incidence rate and a high recurrence rate after cure. The main reason is that the pathogenesis of urolithiasis is not very clear so far, and there is a lack of effective prevention and treatment measures and methods; the incidence of urinary stones has been on the rise in recent years, especially kidney stones directly affect kidney function, which is extremely harmful; Men suffer from the disease more than women. The main clinical symptoms are lumbago, accompanied by varying degrees of hematuria, dysuria, abdominal distension, nausea, vomiting, etc. The main site of disea...
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