Medicine application of fructus teminaliae billaricae extract

A technology of extracts and medicines, which is applied in the field of medicinal use of chebula extracts, can solve problems such as the research on the role of ingredients, and achieve good therapeutic effects

Active Publication Date: 2015-10-21
SUZHOU HEYAN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compositions containing Myrobalan are widely used in China, but no further research has been done on the ingredients and functions of Myrobalan itself

Method used

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  • Medicine application of fructus teminaliae billaricae extract
  • Medicine application of fructus teminaliae billaricae extract
  • Medicine application of fructus teminaliae billaricae extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The preparation of embodiment 1 myrobalan extract

[0023] Get 2kg of myrobalan, after pulverizing, soak 7 days with 16L of 70v% ethanol at room temperature, filter the extract, add 12L of 70v% ethanol to the filter residue, soak for 5 days, filter, and combine the two extracts to obtain the extract. The extract of Myrobalan was vacuum-concentrated to dryness to obtain 679g crude extract of Myrobalan (coded as TB-1), with a yield of 33.9%.

Embodiment 2

[0024] The preparation of embodiment 2 myrobalan extract

[0025] Take 2000g of myrobalan, crush it, extract with 16L of water at 80°C for 50min, filter out the extract, add 12L of water to the filter residue, extract at 80°C for 30min, filter, combine the two extracts to obtain The extract of Myrobalan was vacuum-concentrated to dryness to obtain 830 g crude extract of Myrobalan (coded as TB-2), with a yield of 41.5%.

Embodiment 3

[0026] The preparation of embodiment 3 myrobalan extract

[0027] Take 2000g of myrobalan, crush it, extract it with 16L of 80v% methanol at 60°C for 60min, filter the extract, add 12L of water to the filter residue, extract at 60°C for 40min, filter, combine the two extracts, The obtained extract of Myrobalan was vacuum concentrated to dryness to obtain 597g crude extract of Myrobalan (coded as TB-3), with a yield of 29.8%.

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Abstract

The invention discloses medicine application of fructus teminaliae billaricae extract and particularly relates to application of fructus teminaliae billaricae extract and fructus teminaliae billaricae polyphenol in hyperuricemia medicine preparing. The fructus teminaliae billaricae extract and the fructus teminaliae billaricae polyphenol have the effect of xanthine oxidase activity restraining, uric acid concentration in hyperuricemia model mouse blood can be effectively lowered, the effect of hyperuricemia treating is achieved, and meanwhile the good treating effect is achieved on metabolic diseases related to hyperuricemia, namely gout.

Description

technical field [0001] The invention relates to a medicinal application of a chebula extract, belonging to the field of traditional Chinese medicine preparations. Background technique [0002] In recent years, with the improvement of people's living standards and changes in dietary structure, the intake of sugar, fat, and protein has increased significantly, and the incidence of hyperuricemia and gout has increased day by day, and has become a common disease. [0003] It is generally believed that when the blood uric acid is 416 μmol / L, it is hyperuricemia, and about 5%-12% of patients with hyperuricemia will develop gout. The clinical features are: recurrent gouty acute arthritis, tophi deposition, characteristic chronic arthritis and joint deformities, often involving the kidneys to cause chronic interstitial nephritis and renal uric acid stone formation. The acute attack of gout is an acute inflammatory reaction caused by the deposition of monosodium urate crystal (MSU) ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P19/06
Inventor 夏增华
Owner SUZHOU HEYAN BIOTECH
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