Natural medicine composition, preparation method thereof and application of medicine composition in medicines

A technology of natural medicines and compositions, applied in the direction of drug combinations, pharmaceutical formulations, anti-tumor drugs, etc., can solve the problems of single target, damage, and the need for combined drugs, etc., to achieve the effect of inhibiting tumors

Inactive Publication Date: 2015-10-21
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

New antiemetic drugs are the first choice for antiemetic drugs in clinical cancer chemotherapy, among which 5-HT 3 Receptor antagonist ondansetron has a strong antiemetic effect on acute vomiting caused by cancer chemotherapy, but its scope of application is narrow, it can cause anaphylactic shock and liver damage, and it is ineffective for delayed and expected vomiting, while tachykinins P Substance NK 1 The subtype receptor antagonist aprepitant can be used for delayed emesis, but most of these clinical drugs are chemical synthetic products, which generally have problems such as poor safety, single target, and the need for combined drugs, and no anti-cancer synergistic effect has been seen Therefore, it is urgent to prevent the side effects of nausea and vomiting caused by cancer chemotherapy and the emergence of natural low-toxicity drugs that can synergize cancer treatment

Method used

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  • Natural medicine composition, preparation method thereof and application of medicine composition in medicines
  • Natural medicine composition, preparation method thereof and application of medicine composition in medicines
  • Natural medicine composition, preparation method thereof and application of medicine composition in medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1: the preparation of natural medicine composition of the present invention

[0032] The first step: preparation of capsicum extract

[0033] 1.1. Crush the dried pepper and pass through a 60-mesh sieve;

[0034] 1.2. Using cold soaking method, using n-hexane or 75% ethanol as the extractant, the mixture of chili powder and n-hexane or 75% ethanol

[0035]The ratio of solid to liquid is 1:10, that is, for every 1g of chili powder extracted, use 10mL of n-hexane or 75% ethanol to adjust the pH value of the solution to 8, stir overnight at room temperature, and repeat the extraction 2-3 times;

[0036] 1.3. Combine and filter the leachate, distill the leachate under reduced pressure, remove the solvent to obtain an oily spicy substance, and spray dry to obtain a red powder, which is the pepper extract; the pepper extract contains 1wt% capsaicin.

[0037] The second step: the preparation of proanthocyanidins

[0038] 2.1, get dried grape seeds, grind and siev...

Embodiment 2

[0042] Embodiment 2: the preparation of natural medicine composition of the present invention

[0043] The first step: preparation of capsicum extract

[0044] 1.1. Crush the dried pepper and pass through a 60-mesh sieve;

[0045] 1.2. Using cold soaking method, using n-hexane or 75% ethanol as the extractant, the mixture of chili powder and n-hexane or 75% ethanol

[0046] The ratio of solid to liquid is 1:10, that is, for every 1g of chili powder extracted, use 10mL of n-hexane or 75% ethanol to adjust the pH value of the solution to 8, stir overnight at room temperature, and repeat the extraction 2-3 times;

[0047] 1.3. Combine and filter the leachate, distill the leachate under reduced pressure, remove the solvent to obtain an oily spicy substance, and spray dry to obtain a red powder, which is the pepper extract; the pepper extract contains 1wt% capsaicin.

[0048] The second step: the preparation of proanthocyanidins

[0049] 2.1, get dried grape seeds, grind and sie...

Embodiment 3

[0053] Embodiment 3: the preparation of pharmaceutical composition capsule of the present invention

[0054] Take by weighing 20 mg of capsicum extract and 80 mg of proanthocyanidins prepared in Example 1 or 2, simultaneously weigh 395 mg of starch and 5 mg of magnesium stearate, mix the above-mentioned components uniformly, fill capsules, and make each capsule with a net weight of 500 mg. capsules.

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PUM

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Abstract

The invention relates to a natural medicine composition, a preparation method thereof and application of the medicine composition in medicines used for preventing and treating nausea and vomiting caused by cancer chemotherapy and having a synergistic effect on cancer treatment. The natural medicine composition is composed of a pepper extract and procyanidins, wherein the mass ratio of the pepper extract to procyanidins is 1:(1-9). The natural medicine composition provided by the invention is an innovative natural medicine composition in fit with a polyceptor target proportion, an experiment result shows that the natural medicine composition can be used for preventing and treating nausea and vomiting, comprising acute vomiting and delayed vomiting, caused by cancer chemotherapy and meanwhile, has the effect of assisting tumor inhibition.

Description

technical field [0001] The present invention relates to a natural medicinal composition, more specifically to a natural medicinal composition composed of capsicum extract and proanthocyanidins, a preparation method of the natural medicinal composition, and its ability to prevent side effects of nausea and vomiting caused by cancer chemotherapy And the application of drugs that have a synergistic effect on cancer treatment. Background technique [0002] Vomiting is an unbearable painful reaction for human beings. Cancer radiotherapy and chemotherapy, gastrointestinal diseases, postoperative surgery, motion sickness and pregnancy can all cause vomiting, among which the vomiting caused by cancer chemotherapy drugs is the most intense. For example, the injection of the anticancer drug cisplatin can cause 90% of patients to vomit violently, causing loss of gastrointestinal digestive juice, disturbance of water, electricity, and acid-base balance, and even being forced to give up ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/81A61P35/00A61P1/08C07D311/62A61K31/352A61K31/165
Inventor 杨志宏刘占涛杨玉玲岳旺
Owner QINGDAO UNIV
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