Anti-HIV virus maleic acid B07 gel preparation formula and preparation method

A gel preparation, maleic acid technology, applied in the field of medicine, can solve the problems of safety, effectiveness and acceptability development failure, and achieve the effect of preventing the spread of AIDS, preventing the spread of AIDS, and good biocompatibility

Active Publication Date: 2017-10-20
SHANXI JINBO BIO PHARMA CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among the various new technologies, topical microbicides have attracted the most attention. Topical microbicides can prevent sexual partners from being infected with HIV even without using condoms. Unfortunately, the microbicides currently developed Development failures mostly due to safety, efficacy and acceptability issues

Method used

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  • Anti-HIV virus maleic acid B07 gel preparation formula and preparation method

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Effect test

Embodiment 1

[0049] An anti-HIV virus maleic acid B07 temperature-controlled gel formulation, the ingredients include mass concentrations of 1% maleic acid B07, 4% glycerin, 0.015% sodium hyaluronate, 25% poloxamer 407, 5 % Poloxamer 188, 0.1% Sodium Methylparaben, 0.8% Sodium Propylparaben, 0.13% Phenoxyethanol.

[0050] Taking the preparation of one kilogram of gel as an example, the concentration of maleic acid B07 is 1%, that is, every kilogram of gel contains 10g of maleic acid B07, and the concentration of glycerin is 4%, that is, every kilogram of gel contains 40g of glycerin, hyaluronic acid The sodium concentration is 0.015%, that is, every kilogram of gel contains 0.15g of sodium hyaluronate, the concentration of poloxamer 407 is 25%, that is, every kilogram of gel contains 250g of poloxamer 407, and the concentration of poloxamer 188 5%, that is, every kilogram of gel contains 50g of poloxamer 188, and the concentration of sodium methylparaben is 0.1%, that is, every kilogram of...

Embodiment 2

[0054] An anti-HIV virus maleic acid B07 temperature-controlled gel formulation, the ingredients include mass concentrations of 0.5% maleic acid B07, 2% glycerin, 0.02% sodium hyaluronate, 10% poloxamer 407, 1 % Poloxamer 188, 0.05% Sodium Methylparaben, 0.2% Sodium Propylparaben, 0.2% Phenoxyethanol.

[0055] Taking the preparation of one kilogram of gel as an example, the concentration of maleic acid B07 is 0.5%, that is, every kilogram of gel contains 5g of maleic acid B07, and the concentration of glycerin is 2%, that is, every kilogram of gel contains 20g of glycerin, hyaluronic acid The sodium concentration is 0.02%, that is, every kilogram of gel contains 0.2g sodium hyaluronate, the concentration of poloxamer 407 is 10%, that is, every kilogram of gel contains 100g of poloxamer 407, and the concentration of poloxamer 188 1%, that is, every kilogram of gel contains 10g of poloxamer 188, and the concentration of sodium methylparaben is 0.05%, that is, every kilogram of g...

Embodiment 3

[0061] An anti-HIV virus maleic acid B07 temperature-controlled gel formulation, the ingredients include mass concentrations of 3.5% maleic acid B07, 0.5% glycerin, 0.1% sodium hyaluronate, 50% poloxamer 407, 3 % Poloxamer 188, 0.5% Sodium Methylparaben, 0.01% Sodium Propylparaben, 0.5% Phenoxyethanol.

[0062] Taking the preparation of one kilogram of gel as an example, the concentration of maleic acid B07 is 3.5%, that is, every kilogram of gel contains 35g of maleic acid B07, and the concentration of glycerin is 0.5%, that is, every kilogram of gel contains 5g of glycerin, hyaluronic acid The sodium concentration is 0.1%, that is, every kilogram of gel contains 1g of sodium hyaluronate, the concentration of poloxamer 407 is 50%, that is, every kilogram of gel contains 500g of poloxamer 407, and the concentration of poloxamer 188 is 3%, that is, every kilogram of gel contains 30g of poloxamer 188, the concentration of sodium methylparaben is 0.5%, that is, every kilogram of ...

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Abstract

The invention discloses an anti-HIV gel and a preparation method. The anti-HIV temperature-controlled gel uses maleic acid B07 as the main active ingredient and poloxamer as the main gel. The optimized temperature-controlled gel includes the following components in mass concentration: maleic acid B07 0.2-5%, glycerin 0.5-5%, sodium hyaluronate 0.015-0.25%, poloxamer 407 10-50% , Poloxamer 188 1-5%, sodium methylparaben 0.05-1%, sodium propylparaben 0.01-0.8%, phenoxyethanol 0.13-0.98%, water as the balance. The invention can be used to prevent the spread of AIDS, and has very broad market prospect and application value.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular relates to virology, and specifically relates to a gel product for preventing AIDS and a preparation method thereof. Background technique [0002] AIDS (Acquired immunodeficiency syndrome, AIDS) is an infectious disease caused by human immunodeficiency virus (Human immunodeficiency virus, HIV) infection and characterized by severe damage to the systemic immune system. Since its discovery, it has seriously threatened the survival of human beings. It has a huge impact on global population health and socioeconomic development. The main routes of HIV transmission are unsafe sexual contact, intravenous injection, blood transfusion, childbirth, and breastfeeding. Initially, HIV was only transmitted among drug addicts and homosexuals, but now sexual transmission, especially heterosexual sexual transmission, has become the main way of AIDS transmission. There is a gradually increasing tr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K9/00A61K31/496A61K36/61A61K47/36A61K47/10A61K47/14A61K47/32A61P31/18
Inventor 姜世勃陆路董铭心戴秋云王茜于飞杨霞兰小宾何振瑞王志强
Owner SHANXI JINBO BIO PHARMA CO LTD
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