Unlock instant, AI-driven research and patent intelligence for your innovation.

Preparation of florfenicol soluble powder from acetamide and cyclodextrin

A technology of florfenicol and acetamide, which is applied in the field of preparation of florfenicol soluble powder, can solve problems such as dust pollution, water and energy consumption, and large investment in production equipment

Active Publication Date: 2015-11-25
中农华威生物制药(湖北)有限公司
View PDF5 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] 3. The commercially available products can be used to prepare florfenicol water-soluble powder with co-solvent, but its solubility is not as good as that of β-cyclodextrin inclusion compound
The preparation of florfenicol soluble powder by this technology solves the water-soluble problem of florfenicol, and overcomes the problems of many production processes, low yield, water and energy consumption, dust pollution, and production equipment in the disclosed technology. Insufficient investment

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1, preparation 5% Florfenicol soluble powder

[0020] Take 30g of acetamide and melt it in a 2000ml beaker in a water bath at 85-95°C, then add 50g of florfenicol with a purity greater than 98% in two times to completely dissolve it, then add 500g of β-cyclodextrin step by step , after fully mixing, remove from the water bath, place in a sealed condition at 18-22°C, wait for complete solidification (about 1 hour), break up the agglomerates, pour it into a shearing pulverizer, and pulverize no less than For 20 seconds, open the sealing cover of the pulverizer, clean the top of the cover and the materials attached to the wall with a brush, then cover the sealing cover, and carry out the second crushing. After the crushing, take out the materials and add 420g of lactose fine powder , and mix well to get 5% florfenicol soluble powder.

Embodiment 2

[0021] Embodiment 2, preparation 10% florfenicol soluble powder

[0022] Take 45g of acetamide and melt it in a 2000ml beaker in a water bath at 85-95°C, then add 100g of florfenicol with a purity greater than 98% in 2 times to completely dissolve it, then add 600g of β-cyclodextrin step by step , after fully mixing, remove from the water bath, place in a sealed condition at 18-22°C, wait for complete solidification (about 1 hour), break up the agglomerates, pour it into a shearing pulverizer, and pulverize no less than For 20 seconds, open the sealing cover of the pulverizer, clean the top of the cover and the materials attached to the wall with a brush, then cover the sealing cover, and carry out the second crushing. After the crushing, take out the materials and add anhydrous glucose finely Powder 255g, mix well, obtain 10% florfenicol soluble powder.

Embodiment 3

[0023] Embodiment 3, prepare the 10% florfenicol soluble powder containing SDS

[0024] Take 30g of acetamide and melt it in a 2000ml beaker in a water bath at 85-95°C, then add 100g of florfenicol with a purity greater than 98% in two times to completely dissolve it, then add 600g of β-cyclodextrin step by step , after fully mixing, remove from the water bath, place in a sealed condition at 18-22°C, wait for complete solidification (about 1 hour), break up the agglomerates, pour it into a shearing grinder, and add 10g of SDS at the same time, Pulverize for no less than 20 seconds, open the sealing cover of the pulverizer, clean the top of the cover and the materials attached to the wall with a brush, then cover the sealing cover, and carry out the second pulverization. After the pulverization, take out the material and add Anhydrous lactose fine powder 260g, mix well, obtain 10% florfenicol soluble powder containing SDS.

[0025] When the preparations described in the above-...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses preparation of florfenicol soluble powder by combined application of acetamide and cyclodextrin. A preparation method comprises the following steps: melting the acetamide in a water bath of 80-95 DEG C to obtain acetamide liquid; adding florfenicol into the acetamide liquid stepwise, and slowly stirring till the florfenicol is dissolved to obtain a florfenicol / acetamide solution; adding beta-cyclodextrin into the solution stepwise, stirring while adding, and mixing uniformly to obtain a florfenicol / acetamide / beta-cyclodextrin mixture; removing the mixture from the water bath of 80-95 DEG C, and performing solidification treatment under the conditions of less than 25 DEG C and less than 35 percent in relative humidity to obtain a cured product; scattering and smashing the cured product to obtain the florfenicol soluble powder. In the florfenicol soluble powder, the weight percent content of the florfenicol is 5-15 percent, the weight ratio of the florfenicol to the acetamide is 1:(0.3-0.6), and the weight ratio of the beta-cyclodextrin to the florfenicol is equal to or less than 4.

Description

technical field [0001] The invention relates to the preparation technology of veterinary drug preparations, in particular to the combination of acetamide and β-cyclodextrin, which is applied to the preparation of florfenicol soluble powder. Background technique [0002] Florfenicol is a special chloramphenicol antibiotic for animals and is widely used in veterinary clinics. The florfenicol preparations that have been commercialized in my country include injections and powders. Due to the poor water solubility of florfenicol, the commercially available powders are administered by mixed feeding. In recent years, people are actively developing florfenicol soluble powder for the convenience of administration. At this stage, the research and development of Florfenicol water-soluble powder is mainly carried out around the following aspects. [0003] 1. Prepare the β-cyclodextrin inclusion complex of Florfenicol by adopting β-cyclodextrin inclusion technology, so that Florfenicol...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K47/48A61K9/14A61K47/18A61K31/165A61P31/04
Inventor 王玉万
Owner 中农华威生物制药(湖北)有限公司