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Preparation of Florfenicol Soluble Powder Using Acetamide and Cyclodextrin

A florfenicol and acetamide technology, which is applied in the field of preparation of florfenicol soluble powder, can solve the problems of dust pollution, water and energy consumption, large investment in production equipment and the like

Active Publication Date: 2018-04-20
中农华威生物制药(湖北)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] 3. The commercially available products can be used to prepare florfenicol water-soluble powder with co-solvent, but its solubility is not as good as that of β-cyclodextrin inclusion compound
The preparation of florfenicol soluble powder by this technology solves the water-soluble problem of florfenicol, and overcomes the problems of many production processes, low yield, water and energy consumption, dust pollution, and production equipment in the disclosed technology. Insufficient investment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1, preparation 5% Florfenicol soluble powder

[0020] Take 30g of acetamide and melt it in a 2000ml beaker in a water bath at 85-95°C, then add 50g of florfenicol with a purity greater than 98% in two times to completely dissolve it, then add 500g of β-cyclodextrin step by step , after fully mixing, remove from the water bath, place in a sealed condition at 18-22°C, wait for complete solidification (about 1 hour), break up the agglomerates, pour it into a shearing pulverizer, and pulverize no less than For 20 seconds, open the sealing cover of the pulverizer, clean the top of the cover and the materials attached to the wall with a brush, then cover the sealing cover, and carry out the second crushing. After the crushing, take out the materials and add 420g of lactose fine powder , and mix well to get 5% florfenicol soluble powder.

Embodiment 2

[0021] Embodiment 2, preparation 10% florfenicol soluble powder

[0022] Take 45g of acetamide and melt it in a 2000ml beaker in a water bath at 85-95°C, then add 100g of florfenicol with a purity greater than 98% in 2 times to completely dissolve it, then add 600g of β-cyclodextrin step by step , after fully mixing, remove from the water bath, place in a sealed condition at 18-22°C, wait for complete solidification (about 1 hour), break up the agglomerates, pour it into a shearing pulverizer, and pulverize no less than For 20 seconds, open the sealing cover of the pulverizer, clean the top of the cover and the materials attached to the wall with a brush, then cover the sealing cover, and carry out the second crushing. After the crushing, take out the materials and add anhydrous glucose finely Powder 255g, mix well, obtain 10% florfenicol soluble powder.

Embodiment 3

[0023] Embodiment 3, prepare the 10% florfenicol soluble powder containing SDS

[0024] Take 30g of acetamide and melt it in a 2000ml beaker in a water bath at 85-95°C, then add 100g of florfenicol with a purity greater than 98% in two times to completely dissolve it, then add 600g of β-cyclodextrin step by step , after fully mixing, remove from the water bath, place in a sealed condition at 18-22°C, wait for complete solidification (about 1 hour), break up the agglomerates, pour it into a shearing grinder, and add 10g of SDS at the same time , crush for no less than 20 seconds, open the sealing cover of the pulverizer, clean the top of the cover and the materials attached to the wall with a brush, then close the sealing cover, and carry out the second crushing, and take out the materials after the crushing is completed. Add 260 g of anhydrous lactose fine powder, mix well, and obtain 10% florfenicol soluble powder containing SDS.

[0025] When the preparations described in t...

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PUM

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Abstract

The combined application of acetamide and β-cyclodextrin is used to prepare florfenicol soluble powder. The preparation method is as follows: melting acetamide in a water bath of 80-95 ° C to obtain acetamide liquid; adding fluorine to the acetamide liquid step by step Phranicol, stir slowly to dissolve florfenicol to obtain a florfenicol / acetamide solution; add β-cyclodextrin to the solution step by step, stir while adding, and mix to obtain florfenicol / acetamide / β-cyclodextrin mixture; remove the mixture from the 80-95 ℃ water bath, and perform curing treatment under the conditions of less than 25 ℃ and relative humidity of less than 35% to obtain a cured product; disperse and pulverize the cured product , to obtain florfenicol soluble powder. In the florfenicol soluble powder, the weight percentage of florfenicol is 5-15%, the weight ratio of florfenicol to acetamide is 1:0.3-0.6, and the β-cyclodextrin and florfenicol The weight ratio is equal to or greater than 4.

Description

technical field [0001] The invention relates to the preparation technology of veterinary drug preparations, in particular to the combination of acetamide and β-cyclodextrin, which is applied to the preparation of florfenicol soluble powder. Background technique [0002] Florfenicol is a special chloramphenicol antibiotic for animals and is widely used in veterinary clinics. The florfenicol preparations that have been commercialized in my country include injections and powders. Due to the poor water solubility of florfenicol, the commercially available powders are administered by mixed feeding. In recent years, people are actively developing florfenicol soluble powder for the convenience of administration. At this stage, the research and development of Florfenicol water-soluble powder is mainly carried out around the following aspects. [0003] 1. Prepare the β-cyclodextrin inclusion complex of Florfenicol by adopting β-cyclodextrin inclusion technology, so that Florfenicol...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/69A61K9/14A61K47/18A61K31/165A61P31/04
Inventor 王玉万
Owner 中农华威生物制药(湖北)有限公司