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Human milk compositions and methods of making and using same

A technology of composition and carbohydrates, applied in the field of human milk composition, can solve problems such as not being able to satisfy premature infants

Inactive Publication Date: 2015-12-09
PROLACTA BIOSCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, even the mother's own milk cannot nutritionally satisfy premature infants.

Method used

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  • Human milk compositions and methods of making and using same
  • Human milk compositions and methods of making and using same
  • Human milk compositions and methods of making and using same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0099] Example 1. PROLACTA TM Preparation and Composition of Bioscience Human Milk Fortifier (HMF)

[0100] PROLACTA TM Bioscience Human Milk Fortifier (HMF) (PROLACTPLUS TM ) was prepared using the following steps. Processing is done in a class 100,000 clean room (ISO class 8) and canning is done in a class 10,000 clean room (ISO class 7).

[0101] 1. Mix donor milk.

[0102] 2. Take samples for polymerase chain reaction (PCR) to detect the following viruses:

[0103] a. HIV-1

[0104] b.HBV—hepatitis B

[0105] c.HCV—Hepatitis C

[0106] 3. Strain the donor milk through a 200 micron sieve.

[0107] 4. Heat treatment of donated milk at 63°C or higher for 30 minutes.

[0108] 5. Separate the milk into skim milk and cream with the following concentrations:

[0109] a. Skimmed milk: 0.3%-0.69% fat, 0.9%-1.2% protein, 6%-10% lactose

[0110] b. Cream: 25%-46% fat, 0.5%-2% protein, 8-10% lactose

[0111] 6. If desired, extract and flow the cream through a separator...

Embodiment 2

[0236] Example 2. Various types of PROLACTA based on human milk fortifiers TM Preparation and composition of human milk products become

[0237] Human milk fortifiers (HMFs) prepared as described in Example 1 above were mixed with raw human milk (eg, milk from mothers of preterm infants) at different concentrations. HMF can be mixed in different proportions according to the nutritional content of breast milk and the needs of infants. PROLACT+4 TM It is a composition made by mixing about 80% raw milk and about 20% HMF. PROLACT+6 TM It is a composition made by mixing about 70% raw milk and about 30% HMF. PROLACT+8 TM It is a composition made by mixing about 60% raw milk and about 40% HMF. PROLACT+10 TM It is made by mixing about 50% raw milk and about 50% HMF. Mixing is done by the consumer, not in PROLACTA TM equipment carried out. The following table shows the four PROLACTPLUS in raw milk and mixed with raw milk in different proportions TM Exemplary Nutritio...

Embodiment 3

[0245] Example 3. Preparation and composition of standardized human milk formulations

[0246] PROLACTA TM Biological Sciences NEO20 TM is a standardized human milk formulation prepared as follows. Processing is done in a class 100,000 clean room (ISO class 8) and canning is done in a class 10,000 clean room (ISO class 7).

[0247] 1. Mix donor milk.

[0248] 2. Take samples for polymerase chain reaction (PCR) to detect the following viruses:

[0249] a. HIV-1

[0250] b. HBV-hepatitis B

[0251] c.HCV-hepatitis C

[0252] 3. Strain the donor milk through a 200 micron sieve.

[0253] 4. Ultrafiltration of whole milk. This step strains the water from the whole milk. water as permeate. The final concentration of protein in this step is 1.2%-1.3%.

[0254] 5. Wash the filter after using the permeate to recover protein left on the filter during the ultrafiltration process. Add the post-wash solution to the concentrated whole milk until the protein concentration reach...

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Abstract

The disclosure features human milk fortifier compositions, standardized human milk, and methods of making and using same. In one embodiment, a pasteurized human milk composition includes a human protein constituent of about 35-85 mg / mL; a human fat constituent of about 60-110 mg / mL; and a human carbohydrate constituent of about 60-140 mg / mL.

Description

[0001] This application is a divisional application of the Chinese patent application 200780050590.7 filed on November 29, 2007 with the title of "human milk composition and its preparation and use method". [0002] Cross-references to related applications [0003] This application claims priority to PCT Application PCT / US07 / 19234, filed August 30, 2007, which claims provisional application 60 / 841,371, filed August 30, 2006 and provisional application filed November 29, 2006 Priority of 60 / 867,748. The contents of these applications are incorporated herein by reference in their entirety. technical field [0004] The present disclosure relates to human milk compositions, such as human milk fortifiers and standardized human milk formulations, and methods of making and using such compositions. Background of the invention [0005] Human milk is often the food of choice for preterm and term infants because of its nutritional composition and immune advantages. The source of hum...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23C9/20A23L33/15
CPCA23C9/206A23L1/296A23L1/30A23L1/302A23L1/304A23L1/3056A23L2/52A23L2/66A23L33/40A23L33/10A23L33/15A23L33/16A23L33/19
Inventor E·M·梅多M·L·李D·J·雷希特曼J·富尔耐尔
Owner PROLACTA BIOSCI
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