Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Enteral formulations for preterm infants comprising optimised phenylalanine intake levels

A premature baby, phenylalanine technology, applied in medical preparations containing active ingredients, food science, peptide/protein components, etc., can solve problems such as mental and intellectual disabilities

Active Publication Date: 2017-04-19
NUTRICIA
View PDF7 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This results in an accumulation of high levels of phenylalanine, which can lead to severe and irreversible mental and intellectual disability if left untreated before 3 weeks of age

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Enteral formulations for preterm infants comprising optimised phenylalanine intake levels
  • Enteral formulations for preterm infants comprising optimised phenylalanine intake levels
  • Enteral formulations for preterm infants comprising optimised phenylalanine intake levels

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0160] Example 1: premature birth baby to amino acids ( Phenylalanine ) needs

[0161] This example describes the determination of the requirement of an essential amino acid, phenylalanine, in preterm infants by the indicator amino acid oxidation (IAAO) method, and the subsequent definition of the recommended dietary range for this essential amino acid requirement.

[0162] The infants (n=16) all had a gestational age of 10 g·kg in the first 3 days -1 d -1 weight gain rate.

[0163] IAAO Law

[0164]In the IAAO method, each infant is fed an amino acid-based formula in which every essential amino acid is present in excess except for the amino acid to be tested, phenylalanine. Infants were randomly assigned to receive deficiencies to excesses of the test amino acid (ie, each infant was given a specific intake level of the test amino acid during a test period). Stable isotope-labeled lysine was used as an indicator amino acid for assessing the requirement for phenylalanin...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to enteral formulations for preterm infants (e.g., preterm formulas and human milk fortifiers) containing optimisedintake levels of phenylalaninefor the preterm infants, and particularly relates to a preterm formulation comprising a proteinaceous composition, wherein the preterm formulation (a) comprises 2.0-2.29 g of phenylalanine per 100 g protein; (b) comprises 64.00-82.29 mg of phenylalanine per 100 kcal; and / or (c) provides, or is formulated to provide phenylalanine in an amount of 80-96 mg / kg body weight per day.

Description

technical field [0001] The present invention relates to the determination of optimal intake levels of phenylalanine in preterm infants and to enteral formulations (such as preterm infant formulas and human milk fortifiers) to achieve these optimal intake levels. The invention also relates to the administration of said enteral formulation to premature infants, in particular for the purpose of promoting, assisting or achieving balanced growth and / or development of premature infants. Background technique [0002] Protein deposition is an important part of growth, especially during fetal life and early infancy, which at least partially explains the higher protein requirements of preterm infants. [0003] The protein composition of preterm human milk (i.e., human milk of mothers who have delivered preterm infants) differs from that of term human milk (Zhang 2013) in order to at least partially compensate for these higher requirements. However, despite this transient compensatory...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A23L33/175A23L33/00
CPCA23L33/17A23L33/175A23L33/185A23L33/19A23L33/40A61K38/02A23V2002/00A61K31/198A61K35/20
Inventor E·M·范德比克M·阿布拉哈姆瑟-伯克维尔德J·B·范古德弗I·C·泰勒
Owner NUTRICIA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com