Preparing method for flower traditional Chinese medicinal material decoction-free preparation and application thereof

A technology of Chinese medicinal materials and decoction-free preparation, which is applied in the field of preparation of decoction-free preparations of flower-type Chinese medicinal materials. It can solve the problems of changes in heat-sensitive active ingredients, damage to active ingredients of medicinal materials, and complex chemical components, so as to increase solvent penetration and improve Dissolution speed and dissolution times, good selectivity effect

Inactive Publication Date: 2015-12-09
HENAN XINGZHI PATENT SERVICE CO LTD
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AI Technical Summary

Problems solved by technology

[0004] The preparation of traditional Chinese medicine preparations generally adopts methods such as decoction, reflux, and percolation for extraction, but these extraction methods tend to cause changes in heat-sensitive active ingredients when the temperature rises during the extraction process, and the extraction yield is low. Long time and cumbersome process
Due to the complex chemical composition of Chinese herbal medicines in flowers, traditional extraction methods will also destroy the active ingredients in the medicinal materials

Method used

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  • Preparing method for flower traditional Chinese medicinal material decoction-free preparation and application thereof
  • Preparing method for flower traditional Chinese medicinal material decoction-free preparation and application thereof

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preparation example Construction

[0028] A method for preparing a decoction-free preparation of flower class Chinese medicinal materials, comprising the following steps:

[0029] 1) Pick up the flowers and Chinese herbal medicines, remove impurities and dry them;

[0030] 2) Grinding the dried Chinese medicinal materials into fine powder of Chinese medicinal materials with a particle size of 120-150 μm with an ultrafine pulverizer;

[0031] 3) Put the fine powder of Chinese medicinal materials obtained in step 2) into supercritical CO 2 Extraction is carried out in the extraction device, and then enters the separation tank for separation to obtain extracts and medicinal residues;

[0032] 4) Add 10 to 15 times the volume of an ethanol solution with a volume fraction of 60% to 80% to the medicinal residue obtained in step 3), soak for 30 to 60 minutes, then perform ultrasonic treatment and filter to obtain filtrate and filter residue;

[0033] 5) Add 15 to 20 times the volume of water to the filter residue ob...

Embodiment 1

[0046] Taking magnolia magnolia as an example, the preparation method of its decoction-free preparation comprises the following steps:

[0047] 1) Pick up magnolia to remove impurities, and dry at low temperature under vacuum;

[0048] 2) Grinding the dried magnolia magnolia into a fine magnolia powder with a particle size of 120-150 μm with an ultrafine pulverizer;

[0049] 3) Put magnolia fine powder obtained in step 2) into supercritical CO 2 The extraction is carried out in the extraction device, the extraction temperature is 40°C, the pressure is 25MPa, CO 2 The flow rate is 10L / min, the extraction time is 1.5h, and then it enters the separation tank for separation to obtain the extract and medicinal residues;

[0050] 4) Add 10 times the volume of ethanol solution with a volume fraction of 60% to the dregs obtained in step 3), soak for 30 minutes, and then perform ultrasonic treatment, ultrasonic frequency 20kHz, power 300W, time 30min, repeat 2 times, filter, Obtain ...

Embodiment 2

[0055] Taking Sophora japonica as an example, the preparation method of its decoction-free preparation comprises the following steps:

[0056] 1) Pick up Sophora japonica, remove impurities, and dry at low temperature under vacuum;

[0057] 2) The dried Sophora japonica is crushed into a Sophora japonica fine powder with a particle size of 120-150 μm with an ultrafine pulverizer;

[0058] 3) Put the Sophora japonica fine powder obtained in step 2) into supercritical CO 2 The extraction is carried out in the extraction device, the extraction temperature is 42°C, the pressure is 27MPa, CO 2 The flow rate is 12L / min, the extraction time is 2h, and then it enters the separation tank for separation to obtain the extract and dregs;

[0059] 4) Add 12 times the volume of ethanol solution with a volume fraction of 65% to the dregs obtained in step 3), soak for 40 minutes, and then perform ultrasonic treatment, ultrasonic frequency 22kHz, power 350W, time 35min, repeat 2 times, filte...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine preparing, and particularly relates to a preparing method for a flower traditional Chinese medicinal material decoction-free preparation and an application thereof. The preparing method includes the steps that after flower traditional Chinese medicinal materials are smashed, supercritical CO2 extraction is carried out; ultrasonic-assisted alcohol extraction is carried out, and ultrasonic-microwave cooperation extraction is carried out; then microfiltration treatment is adopted, finally concentrating, drying, nanometer smashing and packaging are carried out, and the flower traditional Chinese medicinal material decoction-free preparation is obtained. The preparation can be used for preparing a Chinese herbal medicine compound preparation containing flower traditional Chinese medicinal materials or flower traditional Chinese medicinal material extract. By means of the preparing method, the problems that when traditional Chinese medicinal material extraction is carried out with a conventional method, the raw material use rate is low, extraction of effective ingredients is incomplete, and extracting efficiency is low are solved; the whole technological process is easy to control and environmentally friendly, and technological steps synergistic interact with each other, so that the extracting efficiency of the preparing method is higher, the effective ingredients are effectively protected, and the utilization degree of the flower traditional Chinese medicinal materials is increased.

Description

technical field [0001] The invention belongs to the technical field of preparation of traditional Chinese medicines, and in particular relates to a preparation method and an application of a decoction-free preparation of flower-type Chinese medicinal materials. Background technique [0002] Traditional Chinese medicine is a unique medicine of traditional Chinese medicine, with a long history and rich resources. The ingredients of traditional Chinese medicine are complex and diverse. If the appropriate extraction, concentration, preparation process and scientific and strict process operation parameters are not selected during the preparation of traditional Chinese medicine preparations, the active ingredients will be incompletely extracted or even destroyed, thereby affecting the efficacy of the medicine. The traditional dosage forms of traditional Chinese medicine include pills, powders, ointments, liquors, etc., but most of the traditional dosage forms have shortcomings suc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/575A61K36/489A61K36/286A61K36/355A61K36/88A61K36/71A61K36/00A61K133/00
Inventor 马新攀
Owner HENAN XINGZHI PATENT SERVICE CO LTD
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