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A new use of anthracene or anthracene compounds

A compound, the technology of anthrabexin, which is applied in the new application field of anthrabexin or anthrabexin, can solve the problem that the cross-inhibition effect needs to be improved, etc.

Active Publication Date: 2018-01-16
MICROBE EPIDEMIC DISEASE INST OF PLA MILITARY MEDICAL ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These reported natural products or compounds have inhibitory effects on the toxin light chain in vitro, and some natural products or compounds also have inhibitory effects at the level of the whole toxin and animal models, but there is still room for improvement in activity
In addition, most of the compounds reported so far have toxin-specific inhibitory activity, but the cross-inhibition effect needs to be improved

Method used

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  • A new use of anthracene or anthracene compounds
  • A new use of anthracene or anthracene compounds
  • A new use of anthracene or anthracene compounds

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Example 1, the protective effect of anthracene or anthracene compounds on animal type A botulinum toxin poisoning:

[0061] 1) Test material: botulinum toxin type A (BoNT / A), its extraction and identification methods refer to literature (C.J.Malizio, M.C.Goodnough, E.A.Johnson, Purification of Clostridium botulinum type Aneurotoxin, Methods Mol Biol.2000,145:27- 39.); Balb / c mice, weighing 14-16g, were purchased from the Experimental Animal Center of the Academy of Military Medical Sciences; type A horse serum antitoxin was purchased from the China Institute for Food and Drug Control; the solvent was normal saline.

[0062] 2) Protective experiment of botulism poisoning: refer to the literature description (C.H.Hatheway, J.D.Snyder, J.E.Seals, T.A.Edell, G.E.Lewis, Jr. Antitoxin levels in botulism patient treated with trivalent equine botulism antitoxin to toxin types A, B, and E .Infect Dis 1984,150:145-151.) mouse botulism model method, the method is as follows: the t...

Embodiment 2

[0065] Example 2, the protective effect of anthracene or anthracene compounds on animal type B botulinum toxin poisoning:

[0066] 1) Test material: botulinum toxin type B (BoNT / B), its extraction and identification methods refer to literature (H.Arimitsu, K.Inoue, Y.Sakaguchi, J.Lee, Y.Fujinaga, T.Watanabe, T. Ohyama, R.Hirst, K.Oguma, Purification of fully activated Clostridium botulinum serotype B toxin fortreatment of patients with dystonia, Infect Immun.71(2003) 1599-1603.); Balb / c mice, body weight 14-16g, purchased From the Experimental Animal Center of the Academy of Military Medical Sciences; type B horse serum antitoxin was purchased from the China Institute for Food and Drug Control; the solvent is normal saline.

[0067] 2) Protective experiment of botulism poisoning: refer to the literature description (C.H.Hatheway, J.D.Snyder, J.E.Seals, T.A.Edell, G.E.Lewis, Jr. Antitoxin levels in botulism patient treated with trivalent equine botulism antitoxin to toxin types...

Embodiment 3

[0070] Example 3, the protective effect of anthracene or anthracene compounds on animal type E botulinum toxin poisoning:

[0071] 1) Test material: Botulinum neurotoxin types B and E (BoNT / E), its extraction and identification methods refer to literature (S.Prabakaran., W.Tepp., B.R.DasGupta., Botulinum neurotoxin types B and E: purification, limited proteolysis by endoproteinase Glu-C and pepsin, and comparison of their identified cleaved sites relative to the three-dimensional structure of type A neurotoxin.Toxicon.2001,39:1515-1531.); Balb / c mice, weighing 14-16g, were purchased from The Experimental Animal Center of the Academy of Military Medical Sciences; E-type horse serum antitoxin was purchased from the China Institute for Food and Drug Control; the solvent was normal saline.

[0072] 2) Protective experiment of botulism poisoning: refer to the literature description (C.H.Hatheway, J.D.Snyder, J.E.Seals, T.A.Edell, G.E.Lewis, Jr. Antitoxin levels in botulism patient ...

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Abstract

The invention discloses a new application of embelin or an embelin compound. The new application refers to the application of the embelin or the embelin compound in preparation of a medicine for preventing and / or treating fusobacterium bacteriotoxin intoxication. The embelin or the embelin compound has an effect of inhibiting and antagonizing fusobacterium neurotoxin in a wider range, so that obvious side effects (serum sickness and allergic reaction) caused by use of a specific antitoxin, namely horse serum are avoided to ensure that the medicine for treating and / or relieving symptoms of the fusobacterium bacteriotoxin intoxication is safer and more efficient in use.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a new application of anthracene or anthracene compounds. Background technique [0002] Clostridium bacterial toxins include botulinum neurotoxin and tetanus toxin. Tetanus toxin is produced by Clostridium tetani in an anaerobic environment and can cause tetanus clinically. Clostridium Botulinum Neurotoxins (Clostridium Botulinum Neurotoxins, referred to as botulinum toxin) is a group of known most virulent proteins (including A-G type), mainly produced by Clostridium botulinum in anaerobic environment, its vein The median lethal dose for injection is about 1ng / kg, and the median lethal dose for inhalation is about 3ng / kg. Common botulinum toxin poisoning occurs mainly due to the consumption of contaminated food, wound infection toxin into the body, and the digestion of toxin precursors in the intestinal tract of infants to produce active toxins. In addition, type A botulinu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/122A61K31/175A61K31/166A61K31/343A61P39/02
CPCY02A50/30
Inventor 王慧李涛卢晓雪刘坤
Owner MICROBE EPIDEMIC DISEASE INST OF PLA MILITARY MEDICAL ACAD OF SCI
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