Temperature-sensitive protective mask patch capable of slowly releasing medicine and preparation method thereof
A protective and slow technology, applied in the fields of botanical equipment and methods, protective clothing, chemicals for biological control, etc., can solve the problems of difficult desorption, waste of resources, poor air permeability, etc., and achieve broad market development prospects, High bioavailability and the effect of increasing availability
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Embodiment 1
[0042] A kind of preparation method of temperature-sensitive slow-release protective mask sticker
[0043] (1) Preparation of shikonin temperature-sensitive nanoparticles:
[0044] (11) Mix 5g of shikonin with 20ml of absolute ethanol to obtain solution A for subsequent use;
[0045] (12) 4g sucrose fatty acid ester and 0.4g triethanol are dissolved in 40ml concentration and mix uniformly in the chitosan solution of 1mg / ml, then mix homogeneously with 20ml solution A to obtain solution B, for subsequent use;
[0046] (13) Slowly add 20ml of 1% sodium tripolyphosphate solution dropwise to solution B while stirring, the stirring speed is 280r / min, the slow adding frequency is 30s / d, the stirring time of volatile organic solvent is 30min, and the crosslinking stirring time For 60min, obtain shikonin temperature-sensitive nanoparticles;
[0047] (2) Preparation of drug-containing gel layer:
[0048] (21) Mix 10g of polyvinylpyrrolidone, 0.5g of silanediol salicylate and 9g of d...
Embodiment 2
[0054] A kind of preparation method of temperature-sensitive slow-release protective mask sticker
[0055] (1) Preparation of shikonin temperature-sensitive nanoparticles:
[0056] (11) Mix 6g of shikonin with 25ml of absolute ethanol to obtain solution A for subsequent use;
[0057] (12) 6g sucrose fatty acid ester and 0.6g triethanol are dissolved in 60ml concentration and mix uniformly in the chitosan solution of 2mg / ml, then mix homogeneously with 20ml solution A to obtain solution B, for subsequent use;
[0058] (13) Slowly add 10ml of 1% sodium tripolyphosphate solution dropwise to solution B while stirring, the stirring speed is 350r / min, the slow dropping frequency is 30s / d, the stirring time of volatile organic solvent is 45min, and the crosslinking stirring time For 80min, obtain shikonin temperature-sensitive nanoparticles;
[0059] (2) Preparation of drug-containing gel layer:
[0060] (21) Mix 8g of polyvinylpyrrolidone, 0.8g of silanediol salicylate and 10g of...
Embodiment 3
[0066] A kind of preparation method of temperature-sensitive slow-release protective mask sticker
[0067] (1) Preparation of shikonin temperature-sensitive nanoparticles:
[0068] (11) Mix 4g shikonin with 20ml absolute ethanol to obtain solution A, set aside;
[0069] (12) 4g sucrose fatty acid ester and 0.4g triethanol are dissolved in 40ml concentration and mix uniformly in the chitosan solution of 1.5mg / ml, then mix homogeneously with 20ml solution A, obtain solution B, for subsequent use;
[0070] (13) Slowly add 10ml of 1% sodium tripolyphosphate solution dropwise to solution B while stirring, the stirring speed is 330r / min, the slow adding frequency is 30s / d, the stirring time of volatile organic solvent is 40min, and the crosslinking stirring time For 70min, obtain shikonin temperature-sensitive nanoparticles;
[0071] (2) Preparation of drug-containing gel layer:
[0072] (21) Mix 7g of polyvinylpyrrolidone, 1g of silanediol salicylate and 12g of drinking water an...
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