Temperature-sensitive protective mask patch capable of slowly releasing medicine and preparation method thereof

A protective and slow technology, applied in the fields of botanical equipment and methods, protective clothing, chemicals for biological control, etc., can solve the problems of difficult desorption, waste of resources, poor air permeability, etc., and achieve broad market development prospects, High bioavailability and the effect of increasing availability

Active Publication Date: 2020-08-14
JIAMUSI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, on the one hand, the number of layers of masks is poor, and on the other hand, there are defects that it is not easy to clean and desorb. Moreover, frequent replacement of masks not only causes waste of resources, but also causes economic burdens for consumers.

Method used

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  • Temperature-sensitive protective mask patch capable of slowly releasing medicine and preparation method thereof
  • Temperature-sensitive protective mask patch capable of slowly releasing medicine and preparation method thereof
  • Temperature-sensitive protective mask patch capable of slowly releasing medicine and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] A kind of preparation method of temperature-sensitive slow-release protective mask sticker

[0043] (1) Preparation of shikonin temperature-sensitive nanoparticles:

[0044] (11) Mix 5g of shikonin with 20ml of absolute ethanol to obtain solution A for subsequent use;

[0045] (12) 4g sucrose fatty acid ester and 0.4g triethanol are dissolved in 40ml concentration and mix uniformly in the chitosan solution of 1mg / ml, then mix homogeneously with 20ml solution A to obtain solution B, for subsequent use;

[0046] (13) Slowly add 20ml of 1% sodium tripolyphosphate solution dropwise to solution B while stirring, the stirring speed is 280r / min, the slow adding frequency is 30s / d, the stirring time of volatile organic solvent is 30min, and the crosslinking stirring time For 60min, obtain shikonin temperature-sensitive nanoparticles;

[0047] (2) Preparation of drug-containing gel layer:

[0048] (21) Mix 10g of polyvinylpyrrolidone, 0.5g of silanediol salicylate and 9g of d...

Embodiment 2

[0054] A kind of preparation method of temperature-sensitive slow-release protective mask sticker

[0055] (1) Preparation of shikonin temperature-sensitive nanoparticles:

[0056] (11) Mix 6g of shikonin with 25ml of absolute ethanol to obtain solution A for subsequent use;

[0057] (12) 6g sucrose fatty acid ester and 0.6g triethanol are dissolved in 60ml concentration and mix uniformly in the chitosan solution of 2mg / ml, then mix homogeneously with 20ml solution A to obtain solution B, for subsequent use;

[0058] (13) Slowly add 10ml of 1% sodium tripolyphosphate solution dropwise to solution B while stirring, the stirring speed is 350r / min, the slow dropping frequency is 30s / d, the stirring time of volatile organic solvent is 45min, and the crosslinking stirring time For 80min, obtain shikonin temperature-sensitive nanoparticles;

[0059] (2) Preparation of drug-containing gel layer:

[0060] (21) Mix 8g of polyvinylpyrrolidone, 0.8g of silanediol salicylate and 10g of...

Embodiment 3

[0066] A kind of preparation method of temperature-sensitive slow-release protective mask sticker

[0067] (1) Preparation of shikonin temperature-sensitive nanoparticles:

[0068] (11) Mix 4g shikonin with 20ml absolute ethanol to obtain solution A, set aside;

[0069] (12) 4g sucrose fatty acid ester and 0.4g triethanol are dissolved in 40ml concentration and mix uniformly in the chitosan solution of 1.5mg / ml, then mix homogeneously with 20ml solution A, obtain solution B, for subsequent use;

[0070] (13) Slowly add 10ml of 1% sodium tripolyphosphate solution dropwise to solution B while stirring, the stirring speed is 330r / min, the slow adding frequency is 30s / d, the stirring time of volatile organic solvent is 40min, and the crosslinking stirring time For 70min, obtain shikonin temperature-sensitive nanoparticles;

[0071] (2) Preparation of drug-containing gel layer:

[0072] (21) Mix 7g of polyvinylpyrrolidone, 1g of silanediol salicylate and 12g of drinking water an...

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Abstract

The invention discloses a temperature-sensitive protective mask patch capable of slowly releasing medicine and a preparation method thereof, and relates to the technical field of traditional Chinese medicine functions. The protective mask patch sequentially comprises a non-woven fabric backing layer, a drug-containing gel layer and an anti-sticking layer, wherein the drug-containing gel layer comprises the following raw materials: alkannin temperature-sensitive nanoparticles, partially neutralized sodium polyacrylate, glycerol, polyvinylpyrrolidone, dihydroxyaluminium aminoacetate, tartaric acid, silanediol salicylate and drinking water. The invention also provides a preparation method of the protective mask patch. The preparation method comprises the following steps: preparing the alkannin temperature-sensitive nanoparticles, preparing the drug-containing gel layer, and coating the anti-sticking layer to obtain the finished product. The selected medicinal materials are wide in source,are mild in drug property, safe and reliable in medication, high in bioavailability, high in nano-material stability and good in product breathability, can slowly release drugs, improves the comfortlevel of the mask patch, and can kill bacteria and viruses adsorbed on the mask in vitro, so that the purpose of prevention is achieved.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine functions, in particular to a temperature-sensitive slow-release protective mask sticker and a preparation method thereof. Background technique [0002] Suspended particles in the air can stay in the atmosphere for a long time, and can enter the human body with breathing, accumulate in the trachea or lungs, and affect health. Due to the warming of the atmosphere caused by the deterioration of the atmosphere, smog is becoming more and more serious nowadays. The substances harmful to health are mainly aerosol particles with a diameter of less than 10 microns, and the diameter of virus particles floating in the air is generally less than 0.3 microns. It can directly enter and adhere to the human respiratory tract and alveoli, especially submicron particles will deposit in the upper and lower respiratory tract and alveoli respectively, causing acute respiratory diseases. [0003]...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A41D13/11A01N25/04A01N25/34A01N35/06A01P1/00
CPCA41D13/1192A01N25/04A01N25/34A01N35/06A41D2400/70
Inventor 张宇李爽赵宏王宇亮沈宇王朝兴李淑贤吴莉莉刘翠娟李桃
Owner JIAMUSI UNIVERSITY
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