Double-component hydrogel

Abstract

The invention discloses double-component hydrogel which comprises the following components: water-soluble polyether-ester with a cross-linking function, a water-soluble natural polymer with the cross-linking function, a reactant and deionized water. As two hydrogel components, namely, the water-soluble polyether-ester and the water-soluble natural polymer with respective advantages, are compounded to use, defects that polyether-ester hydrogel is easy to swell and high in biological inertia and the natural polymer hydrogel is too rapid in in-vivo degradation and poor in mechanical property can be overcome, due to the water-soluble polyether-ester component, mechanical property support and degradation delay can be achieved, due to the water-soluble natural polymer, bioactivity and shape fidelity can be achieved, and after the components are cross-linked and cured, a hydrogel product with controllable mechanical property, degradation behavior and shape and bioactivity can be prepared.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a two-component hydrogel. Background technique [0002] Traditional biological materials are often divided into non-degradable materials and degradable materials according to their degradable characteristics. Among them, non-degradable materials mainly include polyolefins, metals, etc., which are often used to supplement and replace hard tissues such as orthopedics and dentistry. They need to exist stably in the body for a long time to play the role of support and fixation. Degradable materials include poly-alpha ester, polyurethane, natural polymer, etc., which are often used as a short-term scaffold material in the body to provide a temporary internal environment for the damaged area. With the growth of cells and tissues, the material gradually degrades. Eventually replaced by nascent organizations. [0003] Soft materials for other soft tissues (skin, nerves, spinal cor...

AI Technical Summary

Problems solved by technology

[0005] In order to overcome the shortcomings of polyetherester hydrogels, which are easy to swell and biologically inert, and the natural polymer hydrogels are degraded too quickly in vivo and have insufficient mechanical properties, the present invention provides a two-component hydrogel, which is synthesized by polyether Esters and natural polymers, two components with their own advantages, can obtain bioactive hydrogel products with controllable mechanical properties, degradation behavior and shape

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