Shenzhiling Oral Liquid for Treating Cognitive Impairment
A technology of cognitive dysfunction and Zhiling oral liquid, which is applied in the direction of non-living medical raw materials, medical raw materials derived from molluscs, and pharmaceutical formulas, can solve the problems of high risk rate, failure to meet the diagnostic criteria of dementia, and middle and late stage treatment. Poor effect and other problems
Active Publication Date: 2019-03-08
SHANDONG WOHUA PHARMACEUTICALS CO LTD
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Problems solved by technology
However, the risk rate of Alzheimer's disease (AD) in patients diagnosed with MCI is extremely high, and the AD conversion rate is 6% to 25% per year. In the research on neurodegenerative diseases, many clinical cases have shown that Late treatment is not effective, so in recent years researchers have turned to its early diagnosis and preventive intervention
[0004] It is generally believed that MCI represents a cognitive state with a wide range of connotations and different degrees in addition to normal cognition and dementia in the epidemiological survey of dementia. It refers to a clinical state between normal aging and dementia. An individual with this state who has memory impairment beyond what their age and culture allow, but is otherwise functional and does not meet the diagnostic criteria for dementia
Method used
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Embodiment 1
[0075]
[0076] The preparation method is as follows:
[0077] Step 1, take cassia twig, dried ginger, Codonopsis pilosula, Radix Paeoniae Alba, licorice, and calamus and reflux extract with ethanol for 2 times, each time for 1 hour, filter the extract to recover ethanol, and obtain the alcohol extraction extract.
[0078] Step 2, decocting the medicinal residue after alcohol extraction, Poria cocos, polygala, keel, and oysters with water for 2 times, combining the extracts, and filtering; the filtrate is concentrated under reduced pressure to obtain a water extraction extract,
[0079] In step 3, the alcohol extraction extract and the water extraction extract are mixed to obtain active ingredients.
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The invention relates to a traditional Chinese medicine composition, and particularly relates to a codonopsis pilosula-cassia twig-poria cocos oral liquid for the treatment of cognition impairment. The oral liquid disclosed by the invention is prepared from the following herbal materials in parts by weight: 7.5 parts of codonopsis pilosula, 5 parts of cassia twig, 5 parts of radix paeoniae alba, 5 parts of radix liquiritiae, 7.5 parts of poria cocos, 5 parts of rhizoma zingiberis, 4.5 parts of polygala tenuifolia, 5 parts of rhizoma acori graminei, 15 parts of fossil fragments, and 15 parts of concha ostreae.
Description
technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a Shenzhiling oral liquid for treating cognitive dysfunction. Background technique [0002] Cognition is the process in which the human brain receives external information, processes it, and converts it into internal mental activities, thereby acquiring knowledge or applying knowledge. It includes aspects such as memory, language, visuospatial, executive, calculation and comprehension judgments. Cognitive impairment refers to the impairment of one or more of the above several cognitive functions and affects the daily or social ability of the individual. Dementia is diagnosed when two or more of the above cognitive domains are affected and affect the individual's daily or social abilities. [0003] Mild cognitive impairment (MCI) is a chronic degenerative disease of the nervous system, which refers to a state of cognitive impairment between normal aging and dementia,...
Claims
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IPC IPC(8): A61K36/9068A61K9/08A61P25/28A61K35/618A61K35/02
Inventor 周万辉曾英姿王冬梅于洪亮赵磊程世娟
Owner SHANDONG WOHUA PHARMACEUTICALS CO LTD