Ophthalmic implants for delivery of therapeutic substances

A treatment device and eye technology, applied in ophthalmic surgery, ophthalmic treatment, other medical devices, etc., can solve time-consuming, non-providing pharmacokinetics and pharmacodynamics problems

Active Publication Date: 2018-01-26
FORSIGHT VISION5 INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Depending on frequency, intraocular injections can be time consuming for both patient and physician
Thus, in at least some cases, the drug may often be administered less frequently than prescribed, resulting in suboptimal therapeutic effect
In addition, bolus intraocular injection may not provide ideal pharmacokinetics and pharmacodynamics

Method used

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  • Ophthalmic implants for delivery of therapeutic substances
  • Ophthalmic implants for delivery of therapeutic substances
  • Ophthalmic implants for delivery of therapeutic substances

Examples

Experimental program
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Embodiment Construction

[0021] Implantable devices, systems and methods for the delivery of one or more therapeutic agents for the treatment of disease are described herein. The devices and systems described herein can deliver therapeutic agents to selected areas and structures of the body over various periods of time.

[0022] The devices and systems described herein have an improved pierceable access portion for repeated injection and long-term treatment and implantation of the device. It should be appreciated that a pierceable access portion as described herein may be used with a number of different implantable therapeutic devices, including one or more of those described in: U.S. Patent No. 8,399,006; U.S. Patent No. 8,399,006; Patent No. 8,623,395; PCT Patent Publication No. WO2012 / 019136; PCT Patent Publication No. WO2012 / 019047; and PCT Patent Publication No. WO2012 / 065006; the entire disclosures of the foregoing patent documents are incorporated herein by reference.

[0023] eye anatomy

[...

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PUM

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Abstract

The present invention describes implantable therapeutic devices, systems and methods for treating patients. The device comprises a hollow refillable housing (130) for implantation in the posterior segment of the eye through a puncture in the sclera of the eye, comprising a proximal retaining structure (120) protruding outwardly from a proximal region of the housing, an access portion An opening, and a pierceable barrier (140) positioned at least partially within the passage portion opening, the pierceable barrier being configured to be repeatedly pierced. The rigid porous structure (150) is positioned in a region of the housing away from the passage portion opening into a reservoir (160) extending along an axis between the pierceable barrier and the porous structure, the reservoir comprising dimensions A volume determined to deliver a therapeutic amount of a therapeutic agent to the eye over an extended period of time. A cover (110) is coupled to at least an upper surface of the proximal retention structure.

Description

[0001] Cross-reference of priority documents [0002] This application claims priority to U.S. Provisional Patent Application Serial No. 61 / 806,267, filed March 28, 2013, entitled "Ophthalmic Implant for Delivering Therapeutic Substances" Benefit. The priority of this filing date is claimed here and the disclosure of this Provisional Patent Application is hereby incorporated by reference in its entirety. Background technique [0003] Diseases that affect vision can be treated with various therapeutic agents, but delivering drugs to the eye remains challenging. Injecting a therapeutic agent through the eye can be painful and involves some risk of infection, bleeding, and retinal detachment. Depending on the frequency, intraocular injections can be time consuming for both the patient and the physician. Thus, in at least some instances, drugs may often be administered less frequently than prescribed, resulting in suboptimal therapeutic effects. Furthermore, bolus intraocular ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F9/00A61F9/008
CPCA61M39/0208A61F9/0017
Inventor S·埃里克松R·E·坎贝尔D·多特
Owner FORSIGHT VISION5 INC
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