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Application of protocatechualdehyde in the treatment of male infertility and in vitro treatment of sperm

A technology for male infertility and protocatechuic aldehyde, which is applied in the direction of diseases, active ingredients of aldehydes, drug combinations, etc., to improve the integrity of sperm membranes and improve the survival rate of sperm

Active Publication Date: 2017-12-15
NORTH CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no literature report on the use of protocatechualdehyde in the treatment of male infertility and in vitro processing of spermatozoa

Method used

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  • Application of protocatechualdehyde in the treatment of male infertility and in vitro treatment of sperm
  • Application of protocatechualdehyde in the treatment of male infertility and in vitro treatment of sperm
  • Application of protocatechualdehyde in the treatment of male infertility and in vitro treatment of sperm

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Embodiment Construction

[0028] Below in conjunction with accompanying drawing, the present invention will be further described by examples.

[0029] The application of protocatechualdehyde in the treatment of male infertility and in vitro treatment of sperm, the protocatechualdehyde is used in the treatment of male infertility and in vitro treatment of sperm.

[0030] The protocatechuic aldehyde is used to treat male infertility, using a solid preparation;

[0031] Dosage: 4.4 mg / kg (about 300 mg / d);

[0032] Medication method: Oral.

[0033] Medication course of treatment: 1-2 spermatogenic cycles, that is, 3-6 months.

[0034] It can be used alone or in combination with other drugs.

[0035] The protocatechuic aldehyde is used to treat sperm in vitro, made into a powder injection, ready-to-use and ready-to-use, dissolved with a small amount of physiological saline, and then added to sperm nutrient solution for use, with a concentration of 0.1 mg / ml-1 mg / ml.

[0036] The present invention proves...

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Abstract

The invention relates to application of protocatechualdehyde in treatment of male infertility and in-vitro treatment of sperms, belonging to the technical field of treatment of male infertility and in-vitro treatment of sperms. According to a technical scheme in the invention, protocatechualdehyde is applied to treatment of male infertility and in-vitro treatment of sperms; protocatechualdehyde is cheap and can be popularized and applied for treatment of male infertility; protocatechualdehyde has oxidative stress resistance, can increase the content of DJ-1 protein in a testis and is superior to carnitine and vitamin E in treatment of the mechanism of male infertility; when protocatechualdehyde is used for in-vitro treatment of sperms, oxidative stress resistance of protocatechualdehyde can be given to play, oxyradicals generated in in-vitro treatment of sperms can be eliminated, so the morphology and functions of the sperms are protected; and utilization of protocatechualdehyde exerts better effect compared with usage of only a sperm nutrient solution, and protocatechualdehyde is cheap in price and convenient to use (wherein protocatechualdehyde may be directly added into a nutrient solution) and does not lead to obvious increase in operation steps, time and operation cost.

Description

technical field [0001] The present invention relates to the application of protocatechualdehyde in the treatment of male infertility and sperm in vitro, especially the application of protocatechualdehyde in the treatment of male infertility caused by cyclophosphamide, and the application of protocatechualdehyde in the treatment of male infertility caused by cyclophosphamide. The application for preventing and treating male reproductive damage caused by cyclophosphamide belongs to the technical field of treating male infertility and treating sperm in vitro. Background technique [0002] With the development of industrialization, the aggravation of environmental pollution and the increase of social pressure, the quality of male semen has been declining year by year, and the number of male infertility patients has increased significantly. According to the World Health Organization (WHO) standards, couples of childbearing age who live together for more than one year after marria...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/11A61P15/08
Inventor 安春娜张宏宁韩淑英董婧婷杨秋平王博
Owner NORTH CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
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