Sofflower injection and its prepn. method

A technology of injection and safflower, which is applied in the direction of medical formulas, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of difficulty in obtaining curative effect and low content of fat-soluble active ingredients, and achieve stable curative effect, stable content, good curative effect

Inactive Publication Date: 2007-07-25
王锋
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the safflower injection prepared by this method is difficult to obtain a stable and high curative ef

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0027] Example 1

[0028] 1. Take 1kg of chilled fresh safflower, put it in a Soxhlet extractor, add 6000ml of 80% ethanol aqueous solution to heat and reflux for extraction until the percolate is colorless, and 6200ml of percolate is obtained.

[0029] 2. Filter the percolate with a 1.2μm microporous membrane. Concentrate the filtrate on a rotary evaporator and recover ethanol. Concentrate the filtrate to 1500ml and cool to room temperature naturally.

[0030] 3. Transfer the cooled concentrated liquid to a distillation flask with a stirrer, add 300ml petroleum ether, stopper and airtightly stir for 30 minutes, and stand for stratification.

[0031] 4. Siphon out the upper petroleum ether layer, recover the petroleum ether, discard the residue, heat the lower liquid medicine to 90°C to volatilize the residual petroleum ether, add 1500ml of injection water and stir evenly, then add dropwise concentrated ammonia water to adjust the PH=9 to obtain the alkali 3000ml of sex medicine s...

Example Embodiment

[0034] Example 2

[0035] 1 kg of safflower was refrigerated under a nitrogen atmosphere at 0-4°C for 2 hours, and 7500ml of 70% ethanol aqueous solution was added for heating and extraction. According to the method of Example 1, 6000ml of safflower injection was obtained.

Example Embodiment

[0036] Example 3

[0037] A safflower injection was obtained in the same manner as in Example 1, except that 1.5 kg of bright safflower and 7000 ml of a 65% ethanol aqueous solution were used as the extraction solution.

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PUM

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Abstract

A safflower injection with high curative effect is prepared from fresh safflower through cold storage in nitrogen gas, reflux seeping by the aqueous solution of alcohol, filter, concentrating, treating it by petroleum ether, removing petroleum ether and conventionally preparing injection.

Description

technical field [0001] The invention relates to a safflower injection and a preparation method thereof. Background technique [0002] Safflower injection is a modern preparation of traditional Chinese medicine commonly used in clinic. It has good curative effect on cerebral thrombosis, angina pectoris, myocardial infarction, amenorrhea abdominal pain, postpartum blood stasis and trauma swelling and pain. In the past, it was always believed that the active ingredients in safflower injection were mainly fat-soluble components, such as safflower glycosides (safflower glycosides), neosafflower glycosides, safflower quinones, etc., but in recent years, more and more studies Proved that the water-soluble composition safflower yellow in safflower is also its important active ingredient (Takahashi, Miyassaka N, Tasaka SH, etal.Constitution of Cartha mus tinctorius L..Tetrahadron Lett., 1982, 23 (49), pp5163 ), and the main component in safflower yellow is saffloryellow A (safflorye...

Claims

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Application Information

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IPC IPC(8): A61K31/7076A61K31/35A61K9/08A61K36/286A61P9/10A61P15/00A61P29/00A61P19/00A61P17/00
Inventor 郭东宇
Owner 王锋
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