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Sofflower injection and its prepn. method

A technology of injection and safflower, which is applied in the direction of medical formulas, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of difficulty in obtaining curative effect and low content of fat-soluble active ingredients, and achieve stable curative effect, stable content, good curative effect

Inactive Publication Date: 2007-07-25
王锋
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the safflower injection prepared by this method is difficult to obtain a stable and high curative effect due to the low content of fat-soluble active ingredients and almost no water-soluble active ingredients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] 1. Take 1 kg of refrigerated fresh safflower, put it in a Soxhlet extractor, add 6000 ml of 80% ethanol aqueous solution and heat and reflux for extraction until the percolation liquid is colorless, and 6200 ml of percolation liquid is obtained.

[0029] 2. Filter the percolation liquid with a 1.2 μm microporous membrane, concentrate the filtrate on a rotary evaporator, recover ethanol, concentrate the filtrate to 1500 ml, and cool to room temperature naturally.

[0030] 3. Transfer the cooled concentrated solution to a distillation flask with a stirrer, add 300ml of petroleum ether, stopper and stir for 30 minutes, and let stand to separate layers.

[0031] 4. Siphon out the upper layer of petroleum ether, recover the petroleum ether, discard the residue, heat the lower layer of liquid medicine to 90°C, evaporate the residual petroleum ether, add 1500ml of water for injection and stir well, then add concentrated ammonia water dropwise to adjust the pH to 9 to obtain alk...

Embodiment 2

[0035] 1 kg of bright safflower was refrigerated for 2 hours under a nitrogen atmosphere at 0-4° C., and 7500 ml of 70% ethanol aqueous solution was added for heating and extraction. According to the method of Example 1, 6000 ml of safflower injection was obtained.

Embodiment 3

[0037] Except using 1.5kg bright safflower and 7000ml of 65% ethanol aqueous solution as extraction solution, obtain safflower injection in the same manner as in Example 1.

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PUM

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Abstract

A safflower injection with high curative effect is prepared from fresh safflower through cold storage in nitrogen gas, reflux seeping by the aqueous solution of alcohol, filter, concentrating, treating it by petroleum ether, removing petroleum ether and conventionally preparing injection.

Description

technical field [0001] The invention relates to a safflower injection and a preparation method thereof. Background technique [0002] Safflower injection is a modern preparation of traditional Chinese medicine commonly used in clinic. It has good curative effect on cerebral thrombosis, angina pectoris, myocardial infarction, amenorrhea abdominal pain, postpartum blood stasis and trauma swelling and pain. In the past, it was always believed that the active ingredients in safflower injection were mainly fat-soluble components, such as safflower glycosides (safflower glycosides), neosafflower glycosides, safflower quinones, etc., but in recent years, more and more studies Proved that the water-soluble composition safflower yellow in safflower is also its important active ingredient (Takahashi, Miyassaka N, Tasaka SH, etal.Constitution of Cartha mus tinctorius L..Tetrahadron Lett., 1982, 23 (49), pp5163 ), and the main component in safflower yellow is saffloryellow A (safflorye...

Claims

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Application Information

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IPC IPC(8): A61K31/7076A61K31/35A61K9/08A61K36/286A61P9/10A61P15/00A61P29/00A61P19/00A61P17/00
Inventor 郭东宇
Owner 王锋
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