Hirudo small peptide medicine for treating ischemic cerebral apoplexy
A technology for ischemic stroke and leeches, applied in drug combinations, medical raw materials derived from leeches/worms, pharmaceutical formulas, etc., can solve the problems of large dosage, low ingredient content, and poor efficacy, and achieve remarkable results , protect the body's immunity and improve the body's immunity
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Embodiment 1
[0055] Prescription: leech small peptide 60g, total glycosides of cornel 50g, total lactones of ginkgo biloba 50g, total flavonoids of kudzu root 30g.
[0056] Preparation method: Preparation of small leech peptides: Take leeches, crush them properly, add 10 times the amount of water to homogenate for 15 minutes, heat and boil for 30 minutes, let cool to room temperature, use hydrochloric acid to adjust the pH to 2.0±0.1, and then add 5% of the substrate Pepsin, hydrolyze at 37°C for 4 hours, then use sodium hydroxide solution to adjust the pH to 7-10, add trypsin with 5% substrate amount, and hydrolyze at 50°C for 4 hours, stir constantly and adjust the pH at In the range of 7 to 10, continue to heat up and boil for 15 minutes after the enzymolysis is completed, let it cool, centrifuge, collect the supernatant, adjust the pH to 6.5 to 7.0, add 2% activated carbon, stir evenly, filter, and the filtrate uses the cut-off relative molecular mass Perform ultrafiltration for a 3kD ...
Embodiment 2
[0062] Prescription: 120g of small leech peptides, 100g of total glycosides of Cornus officinalis, 100g of total ginkgo biloba lactones, and 60g of total flavonoids of kudzu root.
[0063] Preparation method: Preparation of small leech peptides: Take leeches, crush them properly, add 10 times the amount of water to homogenate for 15 minutes, heat and boil for 30 minutes, let cool to room temperature, use hydrochloric acid to adjust the pH to 2.0±0.1, and then add 5% of the substrate Pepsin, hydrolyze at 37°C for 4 hours, then use sodium hydroxide solution to adjust the pH to 7-10, add trypsin with 5% substrate amount, and hydrolyze at 50°C for 4 hours, stir constantly and adjust the pH at In the range of 7 to 10, continue to heat up and boil for 15 minutes after the enzymolysis is completed, let it cool, centrifuge, collect the supernatant, adjust the pH to 6.5 to 7.0, add 2% activated carbon, stir evenly, filter, and the filtrate uses the cut-off relative molecular mass Perfo...
Embodiment 3
[0069] Prescription: 120g of small leech peptides, 100g of total glycosides of Cornus officinalis, 100g of total ginkgo biloba lactones, and 60g of total flavonoids of kudzu root.
[0070] Preparation method: Preparation of small leech peptides: Take leeches, crush them properly, add 10 times the amount of water to homogenate for 15 minutes, heat and boil for 30 minutes, let cool to room temperature, use hydrochloric acid to adjust the pH to 2.0±0.1, and then add 5% of the substrate Pepsin, hydrolyze at 37°C for 4 hours, then use sodium hydroxide solution to adjust the pH to 7-10, add trypsin with 5% substrate amount, and hydrolyze at 50°C for 4 hours, stir constantly and adjust the pH at In the range of 7 to 10, continue to heat up and boil for 15 minutes after the enzymolysis is completed, let it cool, centrifuge, collect the supernatant, adjust the pH to 6.5 to 7.0, add 2% activated carbon, stir evenly, filter, and the filtrate uses the cut-off relative molecular mass Perfo...
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