The present application relates to the technical field of
traditional Chinese medicine processing, in particular to a kind of
wine stewed fructus corni
oligosaccharide and its preparation method and application.The preparation method comprises: after yellow rice
wine is used to moisten fructus corni, it is stewed by water separation, total
sugar extract is obtained by
defatting,
water extraction,
protein removal and decolorization purification, then
alcohol precipitation grading, freeze-
drying is carried out, and
wine stewed fructus corni
oligosaccharide is obtained.Experimental results show that wine stewing process can significantly improve the proportion of
oligosaccharide in fructus corni total
sugar, and the obtained oligosaccharide can significantly improve the
insulin resistance state of IR-HepG2 cells, and the effect is equivalent to that of
metformin hydrochloride.The present application also discloses the application of the oligosaccharide in preparing drugs for improving
insulin resistance and treating type 2 diabetes.