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A kind of preparation method of compound recipe fenbendazole tablet

A technology of fenbendazole tablet and fenbendazole, which is applied in the field of preparation of recurrent fenbendazole tablet, can solve problems such as toxic and side effects of the body, failure to achieve effect, increase of drug, etc., and achieve good effect, No toxic side effects, good drug dissolution effect

Active Publication Date: 2019-04-09
QINGDAO AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, due to the fact that pets or mammals have cross-infection in daily life and infection by different germs and parasites, they suffer from different diseases, and the causes of the diseases are also complicated. Insects, can not achieve the desired effect, and if take too much of various drugs, on the one hand, the amount of drugs will be relatively increased, causing certain toxic side effects and damage to the body, and on the other hand, it will also cause a lot of waste

Method used

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  • A kind of preparation method of compound recipe fenbendazole tablet
  • A kind of preparation method of compound recipe fenbendazole tablet
  • A kind of preparation method of compound recipe fenbendazole tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Three batches of 1000 tablets of compound fenbendazole tablets were prepared according to the determined formula composition and preparation process.

[0024] Each batch of formula consists of: 454g of fenbendazole, 23g of praziquantel, 0.027g of ivermectin, 908g of starch, 90mg of L-HPC, 50mg of arabic mucilage and 100mg of gelatin pulp, 15g of 1% micronized silica gel and Spartan 1.5g.

[0025] making process:

[0026] The first step, after mixing fenbendazole and starch, superfinely pulverize, pass through a 200-mesh sieve, and set aside the mixture, and pulverize praziquantel and ivermectin respectively, pass through a 100-mesh sieve, set aside;

[0027] In the second step, add 40ml of anhydrous gelatin to the ivermectin crushed in the first step, and ultrasonically dissolve it completely, and set aside;

[0028] The third step, the praziquantel is mixed with the mixture of the first step in a three-dimensional mixer according to the equal amount of incremental me...

Embodiment 2

[0048] Prepare 1000 compound fenbendazole tablets according to the determined formula composition and preparation process.

[0049]Each batch of formula composition: 300mg of fenbendazole, 15mg of praziquantel, 0.01mg of ivermectin, 600mg of starch, 80mg of L-HPC, a mixed solution of 25mg of Arabic mucilage and 75mg of gelatin pulp, 10mg of 1% micronized silica gel and aspirin Patan 1mg.

[0050] making process:

[0051] The first step, after mixing fenbendazole and starch, superfinely pulverize, pass through a 150-mesh sieve, and set aside the mixture, praziquantel and ivermectin are ground and pass through a 100-mesh sieve, respectively, and set aside;

[0052] In the second step, add 20ml of anhydrous gelatin to the ivermectin crushed in the first step, and ultrasonically dissolve it completely, and the obtained ivermectin gelatin solution is ready for use;

[0053] In the third step, mix praziquantel with the mixture obtained in the first step in a three-dimensional mixe...

Embodiment 3

[0059] Prepare 1000 compound fenbendazole tablets according to the determined formula composition and preparation process.

[0060] The composition of each batch of formula: 500mg of fenbendazole, 30mg of praziquantel, 0.05mg of ivermectin, 1000mg of starch, 120mg of L-HPC, a mixed solution of 100mg of arabic mucilage and 100mg of gelatin pulp, 20mg of 1% micronized silica gel and aspirin Patan 3mg.

[0061] making process:

[0062] The first step, after mixing fenbendazole and starch, superfinely pulverize, pass through a 200-mesh sieve, and set aside the mixture, pulverize praziquantel and ivermectin and pass through a 120-mesh sieve, respectively, and set aside;

[0063] In the second step, add 40ml of anhydrous gelatin to the ivermectin crushed in the first step, and ultrasonically dissolve it completely, and the obtained ivermectin gelatin solution is ready for use;

[0064] The third step is to mix praziquantel with the mixture obtained in the first step in a three-dim...

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Abstract

The invention discloses a preparation method of a compound fenbendazole tablet. The preparation method comprises steps of preprocessing raw materials and adjuvant materials; preparing ivermectin gelatin liquid; mixing and granulating; drying and straightening granules; mixing again; tabletting; and packaging: packaging tablets passing full inspection in a brown plastic bottle. The compound fenbendazole tablet prepared by the invention has the beneficial effects that the prepared compound fenbendazole tablet is significant in effect on expelling and killing naturally infected worms in dogs, and a decreasing rate to single egg is 95% or above; the compound fenbendazole tablet is suitable for expelling many worms and is capable of achieving a treatment effect; and the compound fenbendazole tablet is better in effect, safe, free from toxic and side effects, good in drug dissolution, good in reproducibility and stable, and resists high temperature and illumination.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine, in particular to a preparation method of relapse fenbendazole tablet. Background technique [0002] Pet breeding has a long history in our country. With the improvement of living standards and the growth of people's economic ability, more and more people keep pets, including expensive dogs and cats. Pet owners are also paying more and more attention to the health of their pets. Dogs and cats are mammals and are susceptible to parasitic diseases. If they are not treated in time, they will not only threaten the health of pets, but also infect humans. [0003] Fenbendazole is a broad-spectrum, efficient and safe new type of fenbendazole-type contact anthelmintic, which can remove various parasites, developing larvae and eggs in the body, so that the infection cycle can be terminated in the early stage of infection and before maturity. Thereby preventing the reproduction of parasites, i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K9/20A61P33/10A61K31/4985A61K31/4184
Inventor 郝智慧王仕文王蕾蕾王艳丽
Owner QINGDAO AGRI UNIV
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