Acetylcysteine gel, and preparation method and application thereof

A technology of cysteine ​​gel and acetylcysteine, which is applied in the direction of pharmaceutical formulations, aerosol delivery, and medical preparations containing active ingredients, can solve the lack of effective drugs and treatments for oral ulcer care and treatment. Methods and other issues, to achieve the effect of enriching varieties, relieving pain, and good product uniformity

Inactive Publication Date: 2016-03-09
TIANJIN KUNJIAN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, clinicians lack effective drugs and methods for

Method used

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  • Acetylcysteine gel, and preparation method and application thereof
  • Acetylcysteine gel, and preparation method and application thereof
  • Acetylcysteine gel, and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0041] Cool 75g of purified water to 10°C, pass N during the cooling process 2 To dissolved oxygen 2 Dissolved oxygen<2ppm (about 1.7ppm) alkaline solution to adjust the pH value to 6.0, after the acetylcysteine ​​is dissolved, add 0.1g methyl p-hydroxybenzoate and 15g poloxamer (used concentration is 20% (w / v)), increase the stirring speed to form a vortex until the poloxamer is dissolved, let it stand for 24 hours, and filter to obtain the acetylcysteine ​​gel.

Embodiment 2

[0043] Cool 70g of purified water to 1°C, pass N during the cooling process 2 When the dissolved oxygen content is less than 2ppm (about 1.9ppm), add 30g acetylcysteine, 0.1g sodium metabisulfite and 0.1g sucrose and stir to mix. 2 Dissolved oxygen<2ppm (about 1.9ppm) alkaline solution to adjust the pH value to 7.0, after the acetylcysteine ​​is dissolved, add 0.2g sodium benzoate and 20g poloxamer (use concentration is 10% (w / v )), increase the stirring speed to form a vortex until the poloxamer is dissolved, let it stand for 12 hours, and filter to obtain the acetylcysteine ​​gel.

Embodiment 3

[0045] Cool 75g of purified water to 20°C, pass N during the cooling process 2 To dissolved oxygen 2 Dissolved oxygen<2ppm (about 1.8ppm) alkaline solution to adjust the pH value to 5.0, after the acetylcysteine ​​is dissolved, add 1.0g potassium sorbate and 13g poloxamer (use concentration is 25% (w / v)), increase the stirring speed to form a vortex until the poloxamer is dissolved, let it stand for 18 hours, add 0.05g of lemon essence to dissolve and filter, and obtain the acetylcysteine ​​gel.

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Abstract

The invention provides an acetylcysteine gel, and a preparation method and application thereof. The active components, acetylcysteine and poloxamer, of the acetylcysteine gel exert synergistic effect, and the acetylcysteine gel can be used for treating oral ulcer. The acetylcysteine gel prepared in the invention is capable of rapidly relieving pain and preventing and treating ulcer; in particular, the acetylcysteine gel can inhibit continuous expansion of ulcers of patients receiving radiotherapy, chemotherapy and bone marrow transplantation and promote wound healing; the preparation method is simple and can easily realize industrial scale production; and the prepared acetylcysteine gel has the advantages of good uniformity, high stability, moderate viscosity, a single and definite active component and good quality controllability, riches the varieties of drugs used for clinical adjuvant therapy of cancers and offers a good option for nursing of patients receiving radiotherapy.

Description

technical field [0001] The invention relates to the field of acetylcysteine ​​preparations, an acetylcysteine ​​gel for the purpose and a preparation method thereof. Background technique [0002] There are about 3.2 million cancer patients in China every year, which has already posed a huge threat to the health of our country. Radiotherapy, chemotherapy, and bone marrow transplantation have become the routine means for patients to fight cancer, and can receive significant therapeutic effects. However, while these methods suppress cancerous cells, they also cause varying degrees of damage to the body's own immune system, accompanied by the occurrence of various infections. As a non-keratinized site, oral mucosal ulcers are the most common complication in patients receiving radiotherapy, especially in patients receiving head radiotherapy, the incidence of oral ulcers is close to 100%. The symptoms of oral ulcers are mainly as follows: mucosal erythema, edema, ulcers, and at ...

Claims

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Application Information

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IPC IPC(8): A61K31/77A61K9/06A61K47/10A61P1/02A61K31/198
CPCA61K31/198A61K9/006A61K9/06A61K31/77A61K47/10A61K47/12A61K47/14A61K47/18A61K47/26A61K2300/00
Inventor 毛慧华邱东旭郝桂彤王月然姜来刘昊川周密
Owner TIANJIN KUNJIAN BIOLOGICAL PHARMA
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