Composition for preventing hair loss or promoting hair growth containing barley bark extract as an active ingredient

A technology of hair growth and composition, which is applied in the field of anti-hair loss or hair growth-promoting composition, which can solve the problems of preventing hair loss without barley skin, and achieve the effect of inhibiting and preventing hair loss and promoting hair growth

Active Publication Date: 2020-04-21
IND ACADEMIC COOPERATION FOUND JEJU NAT UNIVERSTIY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no record about the anti-hair loss and hair growth-promoting effect of wheat bran in any existing literature

Method used

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  • Composition for preventing hair loss or promoting hair growth containing barley bark extract as an active ingredient
  • Composition for preventing hair loss or promoting hair growth containing barley bark extract as an active ingredient
  • Composition for preventing hair loss or promoting hair growth containing barley bark extract as an active ingredient

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0108] The acquisition and extraction of barley skin

[0109] The barley husk used in the present invention is the barley husk of Chinese wheat cultivated in Gyeongsangbuk-do, Korea, which is obtained from rice milling. Use 90% ethanol every 4 hours to decoct 5 kg of the total wheat husk sample in a water bath (Water Bath) and extract it three times. Thereafter, the supernatant was recovered and concentrated under reduced pressure using a rotary evaporator to obtain 337 g of a crude extract. Of these, 300 g of the mixture was subjected to solvent fractionation with n-hexane (n-hexane) to obtain 133 g of an n-hexane layer, and the fractionated product was used as a sample for the experiment.

Embodiment 2

[0110] Proliferation efficacy of dermal papilla cells

Embodiment 2-1

[0111] Confirmation of proliferation of dermal papilla cells

[0112] Immortalized dermal papilla cells (Rat vibrissa immortalized dermal papilla cells) isolated from the whiskers of white mice were treated with 100 units / ml penicillin-100 μg / ml streptomycin (Gibco Inc, NY, USA) and 10% heat-inactivated fetal Bovine serum (heat-inactivated fetal bovine serum, FBS; Gibco Inc, NY, USA) in DMEM (Hyclone Inc, USA) medium, at 37°C, 5% CO 2 Cultured in a constant temperature machine, subcultured every 3 days.

[0113] The proliferation of dermal papilla cells was measured by MTT Assay. In DMEM medium containing 1% FBS, dermal papilla cells (dermal papilla cell) 1.0×10 4 The cells / ml were turbid and put into a 96-well plate (well plate). After culturing for 24 hours, the wheat peel hexane was fractionated at concentrations of 0.1, 1, 10, 50 and 100 μg / ml. Minoxidil (minoxidil, Sigma, MO, USA) as a positive control group was treated with a concentration of 10 μM.

[0114] After c...

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PUM

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Abstract

The present invention relates to a composition for preventing hair loss or promoting hair growth by containing a bran extract as an active ingredient. The pharmaceutical composition containing the bran extract as an active ingredient, according to the present invention, has a recognized efficacy for suppressing and preventing hair loss and promoting hair growth, and can be variously used in pharmaceutical, cosmetic, food, and beauty care fields or the like.

Description

technical field [0001] The present invention relates to a composition for preventing hair loss or promoting hair growth containing barley bark extract as an active ingredient. Background technique [0002] There are about 100,000-150,000 hairs in the human body, which are formed in "hair follicles". The hair follicle has a nipple, and small blood vessels are distributed in this part to supply the nutrients needed for hair growth, and there is a cortical gland next to the nipple that supplies oil for moisturizing the hair. [0003] Each hair has a cycle that is different from each other, and grows and falls off through anagen (anagen), catagen (catagen), and telogen (telogen). This cycle is repeated after 3-6 years, with an average of 50-100 hairs falling off normally every day. [0004] Usually referred to as alopecia, it is because the proportion of the hair in the growth period is short, the hair in the catagen or telogen period is many, and the number of the hair that f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/899A61K8/9794A61P17/14A61Q7/00A23L33/105
CPCA61K8/9789A61K36/899A61P17/14A61Q7/00A23L33/105A23V2002/00A23V2200/318A23V2250/5106A61K8/9794A61K2236/35
Inventor 姜希炅姜正一金恩智康文祯任东述文祯鲜
Owner IND ACADEMIC COOPERATION FOUND JEJU NAT UNIVERSTIY
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