Biopsy model used for interventional ultrasound

A model and biopsy technology, applied in the medical field, can solve problems such as unfavorable observation, and achieve the effects of less demanding production conditions, easier preservation, and good thermal reversibility

Active Publication Date: 2016-03-30
THE THIRD AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the addition of dyes. The main reason may be that many dyes are easy to penetrate from tumor glue to carrageenan, so that both tumor glue and carrageenan permeate the color of the dye, which is not conducive to observation.

Method used

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  • Biopsy model used for interventional ultrasound
  • Biopsy model used for interventional ultrasound
  • Biopsy model used for interventional ultrasound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The dry product of carrageenan produced in Hainan is mixed with 0.9% (w / w) normal saline at a mass ratio of 1:52, heated to above 70 degrees, dissolved to make a carrageenan solution, and kept at a temperature of about 60 degrees for use.

[0042] Stomach window, Congo red, milk, and carrageenan solution are fully mixed at a mass ratio of 1.5:0.5:10:100 to make liquid tumor glue, which is poured into a spherical mold with a diameter of 1cm or 2cm to cool and solidify to make a tumor model. Put it into the liquid normal tissue glue (the tumor glue can be suspended and fixed in the mold with silk thread and then perfused with the liquid normal tissue glue, or the method of perfusing the normal tissue glue layer by layer, and the tumor is placed in an appropriate position in the middle layer), wait for the liquid After the normal tissue gel is solidified, the model is successfully made. In this embodiment, the liquid normal tissue glue used is the above-mentioned carrageen...

Embodiment 2

[0046] The dry carrageenan produced in Hainan is mixed with 0.9% (w / w) normal saline at a mass ratio of 1:45 and heated to make a carrageenan solution (also used as liquid normal tissue glue) and maintain the temperature in a constant temperature water bath Standby at around 60 degrees. The gastric window, Congo red, milk and carrageenan solution are fully mixed according to the mass ratio of 2.5:1:20:100 to make a liquid tumor glue, and the tumor glue liquid is poured into a spherical mold with a diameter of 1 cm and cooled to room temperature to make a tumor Model. Using the method of layered perfusion, several tumor models were placed in the middle layer of normal tissue glue, and the models were made after cooling to room temperature.

[0047] The ultrasound propagation velocity of the measured model is: 1510m / s (25°C, under standard atmospheric pressure). The ultrasound of the tumor model shows a hyperecho with a clear boundary, a diameter of 10mm, and a distribution dep...

Embodiment 3

[0050] As in Example 1, but the dyes used in the tumor glue are Congo red, methyl blue, carbon black, malachite green, eosin, rose bengal B, and Sudan red. The made models were placed for 1 hour and 24 hours to observe the penetration situation. The results are shown in Table 1 and image 3 shown.

[0051] Table 1 Comparison of model properties when tumor glue uses different dyes

[0052]

[0053] The results show that Congo red has the best effect, which is far superior to other dyes. Its edge is very clear, and the dye does not penetrate into the normal tissue glue at all. The contrast between the tumor glue and the normal tissue glue is very strong, and it can be left for 24 hours or even up to a week. After that, it is still in good condition.

[0054] The effect of methylene blue is second, the boundary can be basically distinguished after being placed for 1 hour, but cannot meet the requirements after being placed for 24 hours; the effect of carbon black is next, t...

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Abstract

The invention belongs to the medical field, relates to biopsy model, containing a normal tissue glue model and a tumor glue model. The tumor glue contains the following ingredients: carrageenan and Congo red. After being embedded in ordinary carrageenan, the tumor glue model is a high-echo lump under ultrasonic display, ordinary carrageenan is colorless and semitransparent in visual inspection, and tumor glue is red and opaque, so the ordinary carrageenan and the tumor glue are strong in contrast and are easy to distinguish. The model is very suitable for serving as a model simulating puncture biopsy guidance by interventional ultrasound.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to the field of interventional diagnosis and treatment under the guidance of ultrasound in ultrasound medicine, and relates to a biopsy model for interventional ultrasound. Background technique [0002] Interventional ultrasound is a commonly used diagnostic or treatment method in clinical practice. It is precise, minimally invasive, and simple. This technology has low requirements for equipment, which can be met by ordinary ultrasound equipment, but it has high requirements for operating doctors, so pay close attention to training. High-quality interventional ultrasound physicians are an important and urgent task before us. In the teaching of interventional ultrasound, students first learn theoretical knowledge, and then practice on the tank model or on experimental animals. The tank model is simple and easy to obtain, but it lacks solid support and it is difficult to simulate the human bod...

Claims

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Application Information

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IPC IPC(8): G09B23/28
Inventor 郑荣琴贺需旗李凯李柳军张奥华
Owner THE THIRD AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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