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EGF (epidermal growth factor) ligand targeted nano drug-loaded system and anti-tumor treatment application thereof

A nano-drug-loading, anti-tumor drug technology, applied in anti-tumor drugs, drug combinations, pharmaceutical formulations, etc., can solve the problems of short circulation time in the body, difficult targeted delivery of anti-tumor drugs, etc., to improve bioavailability, reduce Toxic and side effects, the effect of increasing the concentration

Inactive Publication Date: 2016-04-20
HENAN UNIVERSITY OF TECHNOLOGY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to provide the purpose of the present invention is to construct a nanometer with ligand-specific targeting function for the urgent problems in the treatment of tumors such as difficulty in targeted delivery of anti-tumor drugs, easy degradation, and short circulation time in the body. drug delivery system

Method used

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  • EGF (epidermal growth factor) ligand targeted nano drug-loaded system and anti-tumor treatment application thereof
  • EGF (epidermal growth factor) ligand targeted nano drug-loaded system and anti-tumor treatment application thereof
  • EGF (epidermal growth factor) ligand targeted nano drug-loaded system and anti-tumor treatment application thereof

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Embodiment 1

[0035] A schematic diagram of the construction of an EGF ligand targeting nano drug delivery system see figure 1 The specific preparation steps are as follows:

[0036] (1) Preparation of magnetic nuclei or superparamagnetic nanoparticles (MNPs): Pipette 10.5mL deionized water into a three-necked flask, and add 3mL2mol / L FeCl 3 Solution, start magnetic stirring at an appropriate speed; add 2mL Na dropwise at a constant speed 2 SO 3 ; When the color is reduced from reddish brown to yellow, start slowly adding 80 mL of NH 3 .H 2 O solution, and vigorously stir, the black precipitate is formed quickly; continue to stir for 40 minutes to ensure that the reaction is complete; wash the black precipitate with deoxygenated water 3 times, vacuum dry at 45 ℃, carefully grind and filter to obtain Fe 3 O 4 powder.

[0037] (2) Preparation of drugs-CMC / MNPs by reverse microemulsion method: Take appropriate amount of anti-tumor drugs, CMC and MNPs (mass ratio 2:1) and dissolve them in 5 mL of deio...

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Abstract

The invention discloses an EGF (epidermal growth factor) ligand targeted nano drug-loaded system and an anti-tumor treatment application thereof. According to the drug-loaded system, superparamagnetic nanoparticles are taken as magnetic nuclei, carboxymethyl chitosan is taken as a coating material, an anti-tumor drug is transferred to the coating layer, and the carboxymethyl chitosan surface is modified with an EGF. The EGF ligand targeted nano drug-loaded system has the characteristics of good biocompatibility, high stability, good slow release performance and specific target performance, so that the system has high targeted selectivity on tumor cells, can directionally release a drug to a tumor location, then plays roles of targeted inhibition and tumor cell killing and improves the bioavailability of the drug, and a new strategy is provided for targeted therapy of tumors; a preparation method of nano-carriers and the nano drug-loaded system is simple and convenient to operate, reaction conditions are mild, a prepared product can be taken as a wide carrier for the anti-tumor drug, and a new development direction is provided for study of the efficient anti-tumor drug targeted delivery carrier.

Description

technical field [0001] The invention relates to the field of bionano drug-carrying materials and targeted delivery of drugs, in particular to an epidermal growth factor ligand-targeted nano drug-carrying system and its application in anti-tumor therapy. Background technique [0002] Malignant tumor (cancer) is the first killer that endangers human health and threatens human life. It has the characteristics of high morbidity, high mortality, difficult treatment and easy recurrence. According to the latest "World Cancer Report" by the World Health Organization, there were 14 million new cancer cases and 8.2 million cancer deaths worldwide in 2012. There are 3.07 million newly diagnosed cancer cases in my country, accounting for 21.8% of the global total, and about 2.2 million cancer deaths, accounting for 26.9% of the global cancer deaths. And according to the current trend of cancer incidence, the incidence of cancer worldwide will increase by 50% by 2020. Therefore, tumor ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/02A61K47/42A61K47/36A61K31/475A61P35/00A61K47/62A61K47/69
CPCA61K47/02A61K31/475A61K47/36A61K47/42
Inventor 王雪琴张慧茹崔柳青何慧王小珍常岩岩
Owner HENAN UNIVERSITY OF TECHNOLOGY
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