A kind of flavonoid compound ta31a and its preparation method and use

A technology of flavonoids and trihydroxyflavones, which is applied in the field of medicine and can solve problems such as protein functional differences

Active Publication Date: 2018-07-20
SICHUAN ACAD OF CHINESE MEDICINE SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Experiments Show that Cooking Detrimentally Affects Glycyrrhizin, But It Still Has Useful Functional Properties
In addition, Hojilla-Evangelista[16] also reported the separation of proteins from the seeds of Grucos sativa by salt water extraction or acid precipitation, and evaluated the functions of protein emulsification, stability and foamability, and found that the functionalities of the proteins extracted by the two methods were different.

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  • A kind of flavonoid compound ta31a and its preparation method and use
  • A kind of flavonoid compound ta31a and its preparation method and use
  • A kind of flavonoid compound ta31a and its preparation method and use

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Embodiment Construction

[0069] A flavonoid compound of the present invention is obtained by extracting, separating and purifying from Fructus Grucoides by the following method:

[0070]Take 10kg of scorpion seeds, crush them to 20-40 mesh, add 10 times the volume of 95% ethanol to reflux and extract 3 times, each time for 60min, combine the extracts, filter, and concentrate under reduced pressure to obtain 1.57kg of extract, which is mixed with distilled water Add an equal volume of petroleum ether (60°C-90°C) to the separatory funnel to extract, shake fully, and collect the aqueous phase solution after the mixed liquid is separated. After repeated operations for 5 times, add an equal volume of acetic acid to the aqueous phase solution Ethyl ester extraction, fully oscillated and mixed, after the mixed solution was clarified and stratified, collected the aqueous phase solution, after repeated operations 5 times, the aqueous phase solution was extracted by adding an equal volume of n-butanol, fully osc...

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Abstract

The invention relates to the field of medicine, and specifically relates to a flavonoid compound TA31a, and a preparation method and an application thereof. The compound has a structural formula represented by the formula 1, and is named 6,8,4'-trihydroxyflavone-7-C-glucopyranosyl-4'-O-(4'''-glucopyranosyl)glucopyranoside. The compound is in a form of yellow powder, and has a molecular formula of C33H40O20. The preparation method of the compound is characterized in the following steps: pennycress seed is adopted as a raw material; and the product is obtained through extract extraction, organic solvent extraction, reversed-phase silica gel column chromatography, and high-performance liquid chromatography purification. The compound provided by the invention has clear antioxidant activity, antitumor activity, immunological enhancement activity and PC12 cytoprotection effect. With the compound, a novel choice is provided for clinical applications.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a flavonoid compound TA31a and its preparation method and application. Background technique [0002] Grucodon is a commonly used drug in Tibetan medicine, which belongs to the dried seeds of Grucolum, a plant of the genus Thlaspi arvense L. in the family Brassicaceae. According to the records of traditional medicine classics "Shen Nong's Materia Medica" and "Chinese Materia Medica", the seeds of scorpion are pungent and slightly warm. Mainly improving eyesight, tearing out of eye pain, benefiting eyesight, nourishing the five internal organs, eliminating numbness, dispelling rheumatism, mainly treating conjunctival congestion, swelling and pain, wind-flowing tears, rheumatic arthralgia, etc. The classic Tibetan medicine book "Jingzhu Materia Medica" records that the seeds of 菥蓂子 have the effect of clearing kidney heat and lung heat, and treating various kidney diseases. It is...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H15/26C07H1/08A61P39/06A61P35/00A61P37/04A61P39/00A23L33/105
CPCA23V2002/00C07H1/08C07H15/26A23V2200/30A23V2200/308A23V2200/324A23V2250/2116
Inventor 余梦瑶罗霞许晓燕魏巍江南
Owner SICHUAN ACAD OF CHINESE MEDICINE SCI
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