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Medicinal composition for treating breast cancer and application of medicinal composition

A composition and technology of breast cancer, applied in the direction of drug combination, medical preparations containing active ingredients, antineoplastic drugs, etc., can solve the problems of amiodarone hydrochloride breast cancer and other problems that have not been reported in the literature, and achieve significant social and economic significance , less toxic and side effects

Active Publication Date: 2016-05-04
THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no literature report that amiodarone hydrochloride can be used to fight breast cancer or anti-tumor angiogenesis, and there is no literature report that amiodarone hydrochloride combined with docetaxel is used to treat breast cancer

Method used

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  • Medicinal composition for treating breast cancer and application of medicinal composition
  • Medicinal composition for treating breast cancer and application of medicinal composition
  • Medicinal composition for treating breast cancer and application of medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1: Effect test of amiodarone hydrochloride combined with docetaxel on mice with mammary gland transplantation

[0015] MCF-7 human breast cancer cells were cultured in complete RPMI-1640 medium (containing 10% calf serum, 100IU / ml penicillin, 100IU / ml streptomycin) at 37°C, 5% CO 2 cultured in an incubator for 2 to 3 generations. Human breast cancer MCF-7 cells in the logarithmic growth phase were taken, and the number of cells was adjusted to 5×10 under the microscope. 7 / ml, inoculate 0.1ml / only under the right breast of female nude mice. 2-3 weeks after inoculation, wait for the tumor volume to grow to 150-200mm 3 They were randomly divided into 4 groups, 6 rats in each group, and the tumor formation rate was 100%. Group A: normal saline control group, equal volume, intraperitoneal injection once every other day. Group B: docetaxel single drug group 5mg / kg, once every other day, intraperitoneal injection. Group C: Amiodarone hydrochloride single drug gro...

Embodiment 2

[0031] Example 2: Experimental study on the inhibition of tumor angiogenesis by amiodarone hydrochloride combined with low-dose docetaxel

[0032]Culture MCF-7 human breast cancer cells, adjust the cell concentration to 6×10 7 / ml, 0.1ml / only was inoculated under the breast pad on the right chest wall of nude mice to establish a tumor-bearing animal model. 20 model mice were divided into amiodarone hydrochloride single-drug group (amiodarone hydrochloride, 15mg / kg, once every other day, intraperitoneal injection, continuous 21 days) and low-dose docetaxel single-drug group ( Docetaxel, 2.5mg / kg, once every other day, intraperitoneal injection, continuous 21 days), combined drug group (amiodarone hydrochloride 7.5mg / kg + docetaxel 1.2mg / kg, both once every other day, intraperitoneal injection, continuous 21 days) and normal saline control group (equal volume of normal saline, intraperitoneally injected once every other day, for 21 consecutive days) four groups, 5 rats in each ...

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Abstract

The invention discloses a medicinal composition for treating breast cancer and application of the medicinal composition. The medicinal composition comprises active components such as amiodarone hydrochloride and docetaxel, preferably the active components amiodarone hydrochloride and docetaxel are in a weight ratio of 1:(0.1-1). According to the medicinal composition for treating breast cancer, the purpose of treating breast cancer can be achieved by inhibiting tumor angiogenesis, the active components can take the synergic tumor inhibition effect into play, and a small toxic and side effect can be caused.

Description

technical field [0001] The invention relates to a chemotherapeutic drug, more specifically to a western medicine composition for treating breast cancer and its application, and belongs to the technical field of medicine. Background technique [0002] The female mammary gland is composed of skin, fibrous tissue, mammary glands and fat. Breast cancer is a malignant tumor that occurs in the mammary gland epithelial tissue. The Global Cancer Epidemiological Statistics (GLOBOCAN) shows that about 1.3 million women suffer from breast cancer each year, and 458,000 die from breast cancer. Whether in developed or developing countries, breast cancer is the most common disease faced by women all over the world. Malignant tumors are also an important cause of death in women. Since the 1990s, the incidence rate of breast cancer in China has increased more than twice that of the world, and the number of new breast cancer cases and deaths in China accounted for 12.2% and 9.6% of the world...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/343A61P35/00A61K31/337
CPCA61K31/337A61K31/343A61K2300/00
Inventor 张磊孙健谭晓杰邢志远
Owner THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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