A double-stranded polynucleotide-ε-polylysine-sulfated glycan complex with immunomodulatory effect and its preparation and use method

A double-stranded polynucleotide and sulfated polysaccharide technology, applied in the field of medicine, can solve problems such as antibiotic residues, achieve moderate molecular weight, strong resistance to biological enzyme degradation, and improve the effect of immune regulation activity
CN105535964BActive Publication Date: 2019-01-18北京加益维科生物科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
北京加益维科生物科技有限公司
Publication Date
2019-01-18

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Abstract

The invention provides a double-strand polynucleotide-epsilon-polylysine-sulfuric acid glycan compound with an immune regulating function and a preparing and using method thereof. The invention further provides an immunogen composition with functions of triggering and enhancing immunoreaction and changing immunoreaction types. The immunogen composition contains the double-strand polynucleotide-epsilon-polylysine-sulfuric acid glycan compound and an antigen. The compound is formed by compounding double-strand polynucleotide and anion sulfuric acid glycan with cation epsilon-polylysine and metal cation. The compound has immune-regulating pharmacological activity. The preparing technology of the compound is simple. The compound has good water solubility and a function of resisting biological enzyme degradation. The immunogen composition can trigger and enhance the immunoreaction and change the immunoreaction types.
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Description

technical field

[0001] The present invention relates to the field of medicine. Specifically, the present invention provides a double-stranded polynucleotide-ε-polylysine-sulfated glycan complex with immunoregulatory effect and its preparation method and application method. The present invention also provides an immunogen composition capable of triggering and enhancing immune response and changing the type of immune response and its preparation and use method. Background technique

[0002] 1. Double-stranded polynucleotide: Double-stranded polynucleotide or its derivatives have various pharmacological activities, and the source is natural extraction or artificial synthesis. Artificially synthesized double-stranded polynucleotides such as polyinocytic (polyI:C) can induce the production of interferon in the body, protect cells from virus infection, and have curative effects such as preventing and treating viral diseases; naturally extracted double-stranded polynucleotides such...

Claims

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