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The use of Jiulixiang in the preparation of choleretic drugs

A technology for use and medicine, applied in the field of Jiulixiang, can solve the problem of no choleretic effect and the like, and achieve the effects of abundant medicinal material resources, simple and easy extraction and preparation method, and convenient source of raw materials

Active Publication Date: 2019-11-26
GUANGXI INST OF CHINESE MEDICINE & PHARMA SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no literature report on choleretic effect

Method used

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  • The use of Jiulixiang in the preparation of choleretic drugs
  • The use of Jiulixiang in the preparation of choleretic drugs
  • The use of Jiulixiang in the preparation of choleretic drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] a. Take 1 kg of Gurixiang medicinal material, dry and pulverize it, put it in an extraction container, add 4L of 95% ethanol to soak for 0.5h, heat and reflux for extraction for 1.5h, filter, and collect the filtrate. Add 5 L of 95% ethanol to the dregs, extract for 1.0 h; filter, and collect the filtrate; add 4 L of 95% ethanol to the dregs, extract for 1.0 h; filter, and collect the filtrate. Combine the filtrates for 3 times, recover ethanol until it has no alcohol smell, and concentrate to obtain ethanol extract A;

[0042] b. Cool down the temperature of the ethanol extract A to below 0°C, then add ice water with ice cubes to the ethanol extract A, and grind continuously during the melting of the ice cubes to dissolve the ethanol extract A to form a suspension; control The temperature of the suspension is below 10°C, then extract and wash with petroleum ether, remove the components dissolved in petroleum ether, discard the petroleum ether extract, and the rest is e...

Embodiment 2

[0045] a. Take 1kg of Gurixiang medicinal material, dry and crush it, put it in an extraction container, add 8L of 75% ethanol to soak for 1.0h, heat and reflux for extraction for 1h, filter, and collect the filtrate. Add 6L of 75% ethanol to the dregs, extract for 2 hours; filter, and collect the filtrate; add 6 L of 95% ethanol to the dregs, extract for 1 h; filter, and collect the filtrate. Combine the filtrates for 3 times, recover the ethanol and concentrate it into a paste to obtain the ethanol extract A of Murata japonica.

[0046]b. Cool down the temperature of the ethanol extract A to below 0°C, then add ice water with ice cubes to the ethanol extract A, and grind continuously during the melting of the ice cubes to dissolve the ethanol extract A to form a suspension; control The temperature of the suspension is below 10°C, then extract and wash with petroleum ether, remove the components dissolved in petroleum ether, discard the petroleum ether extract, and the rest i...

Embodiment 3

[0049] a. Take 1kg of Gurixiang medicinal material, crush and sieve it, put it in an extraction container, add 10L of 60% ethanol to soak for 1.5h, heat and reflux to extract for 2.0h, filter, and collect the filtrate. Add 4L of 60% ethanol to the dregs, extract for 3 hours; filter and collect the filtrate; add 8 L of 60% ethanol to the dregs and extract for 1 h under reflux; filter and collect the filtrate. Combine the filtrates for 3 times, recover the ethanol and concentrate it into a paste to obtain the ethanol extract A of Murata japonica.

[0050] b. Cool down the temperature of the ethanol extract A to below 0°C, then add ice water with ice cubes to the ethanol extract A, and grind continuously during the melting of the ice cubes to dissolve the ethanol extract A to form a suspension; control The temperature of the suspension is below 10°C, then extract and wash with petroleum ether, remove the components dissolved in petroleum ether, discard the petroleum ether extract...

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Abstract

The invention discloses the use of Murata japonica in the preparation of choleretic drugs, in particular the new application of the extract of Muria japonica in the preparation of choleretic drugs.

Description

technical field [0001] The present invention relates to the new application of Murata jiulixiang, that is, the application in the preparation of choleretic drugs. Background technique [0002] Biliary tract diseases such as cholelithiasis and cholecystitis are common and frequently-occurring diseases worldwide. Taking cholelithiasis as an example, cholelithiasis occurs in the gallbladder, intrahepatic bile duct and common bile duct. Its prevalence varies with race, heredity, geography, diet, and other factors. In the 1980s, the incidence of cholelithiasis in developed countries such as the United States and Germany was about 10% to 15%. The total detection rate of cholelithiasis in my country is 6.6%, the detection rate in different regions is between 3% and 11%, and the incidence rate of people over 80 years old is as high as 23%. Cholelithiasis can be divided into cholesterol stones, pigment stones and mixed stones, most of which are cholesterol stones, accounting for a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/75A61P1/16A61K127/00A61K135/00
CPCA61K36/75A61K2236/333A61K2236/55
Inventor 何飞韦桂宁曾宪彪农志欢苏华
Owner GUANGXI INST OF CHINESE MEDICINE & PHARMA SCI
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