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Application of a kind of Mauritian patriline in the preparation of choleretic drugs

A choleretic and medicinal technology, which is applied in the field of medicine, can solve the problems that there is no in-depth research on the efficacy of Mauritius pachinin

Active Publication Date: 2022-04-08
CHONGQING MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are no related reports about the effects of Mauritius palisin contained in the total flavonoids of Desmodium desmodium, which have the functions of anti-oxidation, anti-inflammation, and increasing the secretion of total bile acids, or for the preparation of medicines for the treatment of cholecystitis and gallstones. The specific Mauritius papaya There is no in-depth research on the efficacy of

Method used

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  • Application of a kind of Mauritian patriline in the preparation of choleretic drugs
  • Application of a kind of Mauritian patriline in the preparation of choleretic drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] The preparation method of embodiment 1 Mauritius patriline

[0013] Preparation of sample solution: Weigh 2000g of Desmodium chinensis crude powder, extract with 8 times the amount of 70% ethanol under reflux, extract 3 times, each time for 2h, combine the extracts, concentrate the extracts under reduced pressure until there is no alcohol smell, take 10mL as The total extraction part and the rest were stored at 4°C for future use.

[0014] Weigh 1000g of the treated AB-8 macroporous resin, wet-pack the column, add pure water to dilute and filter the crude desmodium extract (crude drug concentration 5mg / mL) onto the column, and adjust the flow rate to 1d / s. After the adsorption is complete, use 3BV of pure water to elute, control the flow rate to 6BV / h, then use 5BV of 30% (or 50% or 70% or 90%) ethanol to elute, control the flow rate to 3BV / h, collect ethanol for elution liquid, concentrated under reduced pressure, and dried to obtain Desmodium 30% ethanol part (I), 50...

Embodiment 2

[0015] Example 2 The active investigation of Mauritius patriline 1

[0016] DPPH free radical scavenging test: DPPH free radical scavenging test. Take 200 μL of Mauritius patriline, add 800 μL DPPH methanol solution, mix well, let it stand at room temperature for 60 min, and measure the absorbance at 517 nm. Pure water was used as blank control.

[0017] Reduction experiment: take 2mL of a series of concentrations of Mauritius patriline, dilute it with methanol to form a solution, add 2.5mL of 1% potassium ferricyanide solution, react in a water bath at 50°C for 20min, and then add 2.5mL of 10% trichloroacetic acid , the mixture was centrifuged at 3000rpm for 10min, 2.5mL of supernatant was taken, and 2.5mL of pure water and 0.5mL of 0.1% FeCl were added to it 3 solution, the absorbance was measured at 700nm. Pure water was used as blank control.

[0018] Determination of NO / nitrite: The release of NO is indirectly reflected by the content of nitrite. Cells were pre-incuba...

Embodiment 3

[0025] Example 3 The active investigation of Mauritius patriline 2

[0026] A total of 50 male and female SD rats were randomly divided into 5 groups after one week of adaptive feeding, with 10 rats in each group. The blank control group was fed with distilled water, the positive drug control group was fed with the Chinese patent medicine Xiaoyan Lidan Tablet suspension, and the experimental group was fed with Mauritius patriline suspension in high, medium and low doses. Gavage once a day for 7 days. On the seventh day, 1 hour after intragastric administration, anesthesia and common bile duct drainage were performed, and the bile flow in the first, second and third hours were recorded respectively, and the changes of bile flow in the three groups at different time periods were observed and compared.

[0027] Experimental results: Through the measurement and observation of bile flow in each group, the bile flow of the control group and the experimental group increased compared...

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Abstract

The invention discloses the use of Mauritius patriline for preparing choleretic drugs, which has the functions of anti-oxidation, anti-inflammation, and increasing total bile secretion, can be used for preparing and treating diseases such as cholecystitis and gallstones, and belongs to the field of medicinal natural products Or health food manufacturing. The applicant found that Mauritius patriline has anti-inflammatory and bile acid secretion promoting effects in vivo and in vitro. At the same time, the present invention discloses the use of Mauritius patriline for preparing choleretic drugs, treating cholecystitis and gallstones, which is widely used in the field of medicine .

Description

technical field [0001] The invention relates to the field of medicine. Mauritius patriline has the functions of anti-oxidation, anti-inflammation and increasing the secretion of total bile acid. Background technique [0002] The medicinal material of money grass is the dried whole herb of Lysimach christinae Hance, which is an authentic medicinal material in Sichuan and Chongqing. There are various chemical components in Desmodium, among which flavonoids are the main active components. It is well known that flavonoids in medicinal plants are a good class of natural antioxidants, which can reduce oxidative stress and the incidence of related diseases. At the same time, it can inhibit the inflammatory process by regulating the production of pro-inflammatory molecules such as tumor necrosis factor (TNF-α) and nitric oxide (NO) produced in the inflammatory process, and reduce cell apoptosis and tissue damage. In daily life, free radicals and reactive oxygen species are continu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P1/16A61P39/06A61P29/00A61K36/185
CPCA61K31/7048A61P1/16A61P39/06A61P29/00A61K36/185A61K2236/333A61K2236/53A61K2236/39A61K2236/51A61K2236/331
Inventor 曹纬国张丹
Owner CHONGQING MEDICAL UNIVERSITY
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