Preparation method and application of medicament for treating insomnia and gel thereof
A gel and drug technology, applied in the field of pharmaceutical preparations, can solve problems such as drug dependence and addiction, and achieve the effects of long administration time, high brain bioavailability, and improved sleep quality
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[0024] The preparation method of the above-mentioned medicinal gel for treating insomnia is specifically implemented according to the following steps:
[0025] Step 1. Weigh separately according to mass percentages: Jujube saponins extract 2%~6%, poloxamer P40716%~22%, poloxamer P1881%~6%, PEG4006%~12%, paraben 0.01%~0.03%, the rest is phosphate buffer, the sum of the above mass percentages is 100%;
[0026] Step 2. Take part of the phosphate buffer solution, add the jujube saponins extract, dissolve it and place it in an ice water bath, slowly add poloxamer P407, poloxamer P188, PEG400 and paraben under magnetic stirring, and add the rest The phosphate buffer solution is evenly moistened and placed in a refrigerator at 4-10°C for 12-48 hours to fully swell and disperse the gel until a clear solution is obtained.
[0027] (1) Gelation temperature (Tgel) measurement experiment:
[0028] Using the "stirring bar method": the gelling temperature (Tgel) of the three groups of the drugs of...
Example Embodiment
[0048] Example 1
[0049] Step 1. Weigh according to mass percentages: Jujube saponins extract 2%, poloxamer P40720%, poloxamer P1884%, PEG40012%, paraben 0.01%, the rest is phosphate buffer, the above-mentioned quality The sum of the percentages is 100%;
[0050] Step 2. Take part of the phosphate buffer solution, add the jujube saponins extract, dissolve it and place it in an ice water bath, slowly add poloxamer P407, poloxamer P188, PEG400 and paraben under magnetic stirring, and add the rest The phosphate buffer solution is evenly moistened and placed in a refrigerator at 4°C for 48 hours to fully swell and disperse the gel until a clear solution is obtained.
Example Embodiment
[0051] Example 2
[0052] Step 1. Weigh separately according to mass percentages: Jujube saponins extract 4%, poloxamer P40722%, poloxamer P1886%, PEG4006%, paraben 0.02%, the rest is phosphate buffer, the above quality The sum of the percentages is 100%;
[0053] Step 2. Take part of the phosphate buffer solution, add the jujube saponins extract, dissolve it and place it in an ice water bath, slowly add poloxamer P407, poloxamer P188, PEG400 and paraben under magnetic stirring, and add the rest The phosphate buffer is evenly moistened and placed in a refrigerator at 8°C for 36 hours to fully swell and disperse the gel until a clear solution is obtained.
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