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Glucose-reducing composition and application thereof

A composition and hypoglycemic technology, applied in the biological field, can solve inconspicuous problems, achieve the effects of inhibiting hepatic steatosis, reducing blood sugar elevation, and wide application prospects

Inactive Publication Date: 2016-06-15
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Both quercetin and anthocyanins have anti-oxidation and blood lipid-lowering effects. The preliminary experimental results of our laboratory show that when quercetin or anthocyanins are used alone, although they have the effect of lowering blood sugar, they are comparable to those of the control group. than not obvious
At present, there is no report on the hypoglycemic effect of quercetin and anthocyanin synergistically

Method used

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  • Glucose-reducing composition and application thereof
  • Glucose-reducing composition and application thereof
  • Glucose-reducing composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) Establishment of mouse diabetes model and treatment of quercetin:

[0025] Female and male c57BL / 6 mice were randomly divided into three groups, 15 in each group. One group was fed with common feed (common feed was purchased from the Academy of Military Sciences, and the distribution ratio of the groups was shown in Table 1, and the mice were allowed to eat freely every day); one group was fed with high-fat feed; one group was fed with quercetin and The high-fat feed of anthocyanins (the high-fat feed is D12492, and the composition ratio is shown in Table 2), the mice are allowed to eat freely every day, and each mouse takes an average of 1.70-2.00g of food every day. The amount of quercetin ingested was 1.70-2.00 mg, and the amount of anthocyanin ingested by each mouse was 0.714-0.84 mg per day. After 12 weeks of treatment, the body weight and fasting blood glucose of the mice were measured every week, as well as the insulin resistance test of the mice in each gro...

Embodiment 2

[0035] This example is an in vitro experiment, macrophages were treated with palmitic acid, and then the cells were treated with quercetin to detect the expression of cytokines.

[0036] Firstly, the peritoneal macrophages of mice were extracted and randomly divided into four treatment groups. The first group was a negative control, the second group was induced with 5mM palmitic acid to simulate the in vivo fat degeneration model, and the third group was added palmitic acid at the same time. 200mg / ul of quercetin, the fourth group added 200mg / ul of quercetin and anthocyanins at the same time as palmitic acid, after 24 hours of treatment, the cells were harvested, and the cellular RNA was extracted to detect the transcriptional level of inflammatory factors in each group expression changes. Experimental results such as Figure 5 as shown, Figure 5 Middle 1640 represents the medium used for culturing peritoneal macrophages.

[0037] according to Figure 5 It can be seen tha...

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Abstract

The invention relates to a hypoglycemic composition and the application of the composition. The hypoglycemic composition contains the following components in parts by weight: 50-150 parts of quercetin and 35-48 parts of anthocyanin. The composition provided by the present invention can significantly reduce the rise in blood sugar caused by a high-fat diet, inhibit insulin resistance and hyperglycemia caused by obesity, and inhibit the The resulting hepatic steatosis and the suppression of the expression of inflammatory factors at the transcriptional level caused by overnutrition have broad application prospects.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a hypoglycemic composition and its application. Background technique [0002] Diabetes is a major disease that endangers the health of modern people. The incidence of diabetes in adult males and females in my country is 11% and 10.5%, respectively. There are more than 92.4 million diabetic patients in my country, and another 139 million belong to the "reserve army" of diabetes. China has replaced India as the world's largest diabetes country. According to the World Health Organization, one person dies from diabetes every 10 seconds, and one person has amputation due to diabetes every 30 seconds. In addition to blindness, cardiovascular and cerebrovascular complications, diabetes has become a serious public health problem. [0003] The means currently used to treat diabetes include insulin therapy and drug therapy, and the types of drugs mainly include sulfonylureas, biguanide hypogl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/353A61K31/352A61P3/10A61P1/16
CPCA61K31/353A61K31/352
Inventor 李向东郭仰东樊晗璐
Owner CHINA AGRI UNIV
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