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Longma pellets having anti-inflammatory and analgesic effects as well as preparation method and application of pellets

An anti-inflammatory analgesic and pellet technology, applied in the field of Longma pellets and their preparation, can solve the problems of many adverse reactions, application limitations, etc., and achieve the effects of good absorption effect, high bioavailability, and avoidance of incompatibility.

Inactive Publication Date: 2016-06-15
XIANGTAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Although tripterygium glycosides (TWH) has been widely used in the treatment of rheumatoid arthritis due to its remarkable curative effect in recent years, its application is also limited due to its many adverse reactions.

Method used

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  • Longma pellets having anti-inflammatory and analgesic effects as well as preparation method and application of pellets
  • Longma pellets having anti-inflammatory and analgesic effects as well as preparation method and application of pellets
  • Longma pellets having anti-inflammatory and analgesic effects as well as preparation method and application of pellets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] (1) Mix the pharmaceutical excipients with the above-mentioned nuxychon and earthworm evenly in the presence of water and absolute ethanol (amount by weight ratio of 1:20), wherein the amount of the water and absolute ethanol is such that the mixing The solid content of the mixture obtained after homogenization is 45% by weight;

[0067] (2) The mixture obtained in step (1) is placed in an extrusion spheronizer and extruded through an orifice to form thin strips with uniform diameters, and then the extruded thin strips are placed in a high-speed rotating spheronizer for spheronization , making the thin strip material fully cut into a short cylindrical shape, and continue to spheronize until the material is completely rolled into a ball, wherein the extrusion speed is 300r / min, and the spheronization speed is 800r / min.

[0068] (3) drying the spherical pellet precursor obtained in step (2) at 40° C. for 6 h, and sieving the dried material to obtain Longma pellets with an...

Embodiment 2

[0071] (1) Mix the pharmaceutical excipients with the above-mentioned nuxyche and earthworm evenly in the presence of water and absolute ethanol (amount by weight ratio of 17:3), wherein the amount of the water and absolute ethanol is such that the mixing The solid content of the mixture obtained after homogenization is 50% by weight;

[0072] (2) The mixture obtained in step (1) is placed in an extrusion spheronizer and extruded through an orifice to form thin strips with uniform diameters, and then the extruded thin strips are placed in a high-speed rotating spheronizer for spheronization , making the thin strip material fully cut into a short cylindrical shape, and continue to spheronize until the material is completely rolled into a ball, wherein the extrusion speed is 300r / min, and the spheronization speed is 800r / min.

[0073] (3) drying the spherical pellet precursor obtained in step (2) at 50° C. for 5 h, and sieving the dried material to obtain Longma pellets with an ...

Embodiment 3

[0076] (1) uniformly mixing the pharmaceutical excipients with the above-mentioned nuxychee and earthworm in the presence of absolute ethanol, wherein the amount of the absolute ethanol is such that the solid content of the resulting mixture after mixing is 65% by weight;

[0077] (2) The mixture obtained in step (1) is placed in an extrusion spheronizer and extruded through an orifice to form thin strips with uniform diameters, and then the extruded thin strips are placed in a high-speed rotating spheronizer for spheronization , making the thin strip material fully cut into a short cylindrical shape, and continue to spheronize until the material is completely rolled into a ball, wherein the extrusion speed is 300r / min, and the spheronization speed is 800r / min.

[0078] (3) Drying the spherical pellet precursor obtained in step (2) at 75° C. for 15 h, and sieving the dried material to obtain Longma pellets with an average particle diameter of 0.6-0.8 mm.

[0079] The compositi...

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Abstract

The invention relates to the field of traditional Chinese medicines and discloses Longma pellets having anti-inflammatory and analgesic effects as well as a preparation method and an application of the pellets. The composition is prepared from active pharmaceutical ingredients and pharmaceutical adjuvants, wherein the active pharmaceutical ingredients are prepared from nux vomica and earthworms in the weight ratio being 1:(0.1-10), and the average particle diameter of the Longma pellets is 0.038-4 mm. The Longma pellets can have the good anti-inflammatory and analgesic effects on the premise that the pellets are safe and non-toxic, and particularly, the Longma pellets can effectively treat rheumatoid arthritis.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to Longma pellets for anti-inflammatory and analgesic effects, a preparation method and application thereof. Background technique [0002] In recent years, anti-inflammatory and analgesic drugs have become more and more widely used, and have become one of the most widely used drugs in prescription and over-the-counter drugs. [0003] At present, the most widely used anti-inflammatory and analgesic drugs are traditional non-steroidal anti-inflammatory drugs (NsAIDs), represented by aspirin, acetaminophen, ibuprofen, etc., and their consumption in my country is second only to anti-infective drugs . These drugs mainly inhibit the activity of cyclooxygenase II (COX-II), and then inhibit the synthesis of inflammatory prostaglandins, resist inflammation, and relieve symptoms such as fever and pain caused by inflammation. Because these drugs can inhibit the activity of cycloox...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/56A61K9/16A61P29/00A61P19/00A61P19/02A61P25/02A61P9/06A61P11/06A61P11/00A61P7/02A61K35/62
CPCA61K9/1617A61K9/1652A61K35/62A61K36/56A61K2300/00
Inventor 吴萍杨春光胡不群帅词俊
Owner XIANGTAN UNIV
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