Method for preparing semen strychni and earthworm pellets

A technology for pellets and earthworms, which is applied in pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc. The problem of evaporation rate of water in binders and materials, etc., to achieve the effect of suitable dissolution rate, excellent roundness and yield

Active Publication Date: 2016-05-25
XIANGTAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, the extrusion spheronization process will generate heat, which may destroy some active ingredients in traditional Chinese medicine; too high temperature will also affect the evaporation rate of moisture in the binder and materials, thereby affecting the properties of the pellets and the dissolution of the drug

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] (1) In the presence of 77mL water and 8mL absolute ethanol, 20g Nuxychia and 25g Earthworm are mixed with the WJ-101 type microcrystalline cellulose of 55g,

[0068] (2) The mixture obtained in step (1) is granulated by extrusion spheronization to obtain a spherical pellet precursor, wherein the conditions of the extrusion spheronization method include: the extrusion speed is 280r / min, and the spheronization speed is 650r / min, rounding time is 40min;

[0069] (3) drying the spherical pellet precursor obtained in step (2) at 35° C. for 30 h;

[0070] (4) Pass the material obtained after drying in step (3) through a 32-mesh sieve to obtain Longma pellets with an average particle diameter of 0.55 mm, with a yield of 87.6%.

Embodiment 2

[0072] (1) In the presence of 75mL water and 15mL absolute ethanol, 20g Nuxychia and 35g Earthworm are mixed with the WJ-101 type microcrystalline cellulose of 45g,

[0073] (2) The mixture obtained in step (1) is granulated by extrusion spheronization to obtain a spherical pellet precursor, wherein the conditions of the extrusion spheronization method include: the extrusion speed is 250r / min, and the spheronization speed is 600r / min, rounding time is 35min;

[0074] (3) drying the spherical pellet precursor obtained in step (2) at 40°C for 24h;

[0075] (4) Pass the material obtained after drying in step (3) through a 32-mesh sieve to obtain Longma pellets with an average particle diameter of 0.55 mm, with a yield of 88.1%.

Embodiment 3

[0077] (1) In the presence of 82mL of water and 13mL of absolute ethanol, 30g of Nuxychia and 30g of Earthworm are mixed with 40g of WJ-101 type microcrystalline cellulose,

[0078] (2) The mixture obtained in step (1) is granulated by the extrusion spheronization method to obtain a spherical pellet precursor, wherein the conditions of the extrusion spheronization method include: the extrusion speed is 350r / min, and the spheronization speed is 700r / min, rounding time is 30min;

[0079] (3) drying the spherical pellet precursor obtained in step (2) at 50° C. for 18 hours;

[0080] (4) Pass the material obtained after drying in step (3) through a 32-mesh sieve to obtain Longma pellets with an average particle diameter of 0.55 mm, with a yield of 87.3%.

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Abstract

The invention relates to the field of traditional Chinese medicines, and discloses a method for preparing semen strychni and earthworm pellets. The method comprises the following steps: (1) mixing semen strychni and earthworms with medicinal auxiliaries in the presence of a solvent; (2) granulating the mixture in the step (1) by adopting an extrusion-spheronization method to obtain spherical pellet precursors, and controlling the condition of the extrusion-spheronization method to enable the average particle diameter of the spherical pellet precursors to be less than 4mm; and (3) drying the spherical pellet precursors obtained in the step (2). The medicinal auxiliaries comprise excipients which are starch and/or microcrystalline cellulose. The semen strychni and earthworm pellets prepared by the method have excellent roundness and yield and excellent dissolution rate.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a method for preparing Longma pellets. Background technique [0002] Pellets usually refer to various spherical or quasi-spherical oral preparations with a diameter of less than 2.5mm, which belong to the multi-unit drug delivery system and have the characteristics of beautiful appearance, good fluidity, large specific surface area, and high bioavailability. [0003] Most of the traditional Chinese medicine pellets are prepared from the active ingredients or effective parts of traditional Chinese medicine or traditional Chinese medicine compound, the thick extract or amorphous powder obtained through extraction and purification, and suitable auxiliary materials. The excellent properties of the pellets are reflected in their fluidity. Good, uniform particle size, stable drug release, and easy to coat, pack into capsules, and divide doses. [0004] After coating, Chine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K47/38A61K47/36A61K36/56A61P29/00A61P19/02A61P19/08A61P25/00A61P25/02A61P9/06A61P9/10A61P7/02A61P11/06A61P11/00A61K35/62
CPCA61K9/1652A61K35/62A61K36/56A61K2300/00
Inventor 杨春光吴萍胡不群帅词俊
Owner XIANGTAN UNIV
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