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Chlorine dioxide containing injection and preparation method thereof

A chlorine dioxide and chlorine dioxide precursor technology, applied in the field of injections, can solve problems such as unsafe, low pH value of the mixed solution, and inability to be used as injections, etc., and achieve the effect of stimulating immune response and promoting tissue regeneration in situ

Pending Publication Date: 2016-07-06
刘学武
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In general use, there is no adverse effect, but it may bring unsafe factors as an injection
In order to react more fully, it is often necessary to add an excessive amount of acid to make the pH of the mixed solution lower, which may make it impossible to be used as an injection for injecting the human body.

Method used

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  • Chlorine dioxide containing injection and preparation method thereof
  • Chlorine dioxide containing injection and preparation method thereof
  • Chlorine dioxide containing injection and preparation method thereof

Examples

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Effect test

preparation example Construction

[0030] The chlorine dioxide injection containing exceeding solubility of the present invention, its preparation method comprises the following steps:

[0031] 1. Produce chlorine dioxide gas with a concentration of 99.9% through a standardized method. The method for producing high-purity chlorine dioxide gas is known to those skilled in the art. For example, a common practice is to generate chlorine dioxide gas by reacting a chlorine dioxide precursor (chlorite) with an acid. In addition, there is a mixed reaction of disulfate and chlorite to produce chlorine dioxide gas.

[0032] 2. After the chlorine dioxide gas is prepared through the above reaction, it is introduced into the medium at minus 20 degrees Celsius to 11 degrees Celsius through the pipeline. The introduced medium can be directly introduced into air, nitrogen and other gaseous media or can be bubbled into the containing Diluted solutions of pharmaceutically acceptable additives commonly used in injections (such ...

Embodiment 1

[0037] Embodiment 1: Contain the preparation of 15mg / ml chlorine dioxide injection

[0038] Mix 28% sodium chlorite solution and 50% citric acid solution in the reaction kettle, guide the tube into the normal saline solution containing 0.9% sodium chloride at 1 degree Celsius, and submerge the inlet of the tube into the normal saline. The reaction kettle was heated at a constant temperature of 85 degrees Celsius for 30 minutes, and chlorine dioxide was bubbled into the physiological saline, which was always kept at a constant temperature of 1 degree Celsius by external equipment. After 30 minutes, transfer the mixed solution to an airtight container and place it at 20 degrees Celsius. After the chlorine dioxide and physiological saline are evenly mixed, store it in a refrigerator at 2-8 degrees Celsius. The chlorine dioxide solution with a concentration of 15 mg / ml was prepared through determination. The solution can be divided into 10ml glass bottles as an injection, and sto...

Embodiment 2

[0039] Embodiment 2: the toxicity test containing chlorine dioxide injection

[0040] Chlorine dioxide injection preparation: Injection A, that is, the chlorine dioxide precursor is mixed with acid to prepare an injection solution with a concentration of about 1.5%. Use deionized water to prepare a mixed solution of 7.47% sodium chlorite and 1.59% sodium chloride to prepare the first solution; use deionized water to prepare a citric acid solution with a concentration of 16.7% to prepare the second solution . Take out the same volume of solutions from different solution containers, mix them, and wait for the solutions to mix and stand still for 3 to 5 minutes. The detected chlorine dioxide concentration is about 1.5%, the pH is about 2.1, and it is used for injection within 30 minutes. Injection B, that is, an injection in which the chlorine dioxide precursor is mixed with acid and then adjusted to pH 7 by adding sodium hydroxide. Use deionized water to prepare a mixed solut...

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Abstract

The invention relates to a chlorine dioxide containing injection for treatment directions of promotion of regeneration of stem cells in human bodies, anti-tumor, anti-aging and the like. An injection with high chlorine dioxide content is prepared by introducing standard chlorine dioxide with the concentration of more than 99.9 percent into a medium such as air of lower than 11 DEG C or a cold physiological saline solution reaching the temperature of lower than 11 DEG C in a bubbling manner or a solution comprising other pharmaceutically acceptable additives adopted for ordinary injections and dissolving the chlorine dioxide in the medium. The chlorine dioxide containing injection has good pharmacodynamic effects and low toxic or side effects, tumors can be ablated, in-situ tissue regeneration can be promoted, and particularly when target tumors are ablated, immune responses can be provoked and an immune system can be induced to inhibit or destroy distal tumors and metastatic tumors. Moreover, the invention provides a preparation method for the chlorine dioxide containing injection.

Description

technical field [0001] The invention relates to an injection containing chlorine dioxide in the therapeutic directions of promoting stem cell regeneration in the body, anti-tumor and anti-aging, and particularly relates to an injection preparation with high efficacy and low toxicity and side effects, which can be stored for a long time and a preparation method. Background technique [0002] Chinese patent CN103040860A proposed for the first time that stem cells in the body can be activated to achieve regeneration through direct administration, so as to treat corresponding diseases, and an injection containing chlorine dioxide is mentioned. Chinese patent CN103720709A proposes for the first time that senescent cells in the target tissue can be cleaned up and tumor cells can be ablated by direct administration, so that the administration of chlorine dioxide preparations can be used for anti-aging and anti-tumor, that is, for the treatment of aging diseases and cancer. and inje...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K33/00A61P35/00A61P39/06
CPCA61K9/0019A61K9/08A61K33/00A61K47/02A61P35/00
Inventor 刘学武刘学燕
Owner 刘学武
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