Preparation method of durio zibethinus murr shell extract and application of durio zibethinus murr shell extract

A technology of extract and durian shell, which is applied in the field of preparation of durian shell extract, can solve the problems of rare reports on the pharmacological activity of durian shell, and achieve the effect of simple preparation method

Inactive Publication Date: 2016-08-03
贺灿炎
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Residents in Southeast Asia and South China often use durian shells to make soup, decoct water, etc., to achieve the effects of reducing fire and stagnation, nourishing blood and nourishing qi, nourishing yin, etc., but there are few reports on the pharmacological activity of durian shells.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A preparation method of durian shell extract, comprising the following steps:

[0020] (1) Take the white capsule endothelium in the durian peel, clean it, chop it into pieces, put it into a drying oven at 100° C., and dry it to constant weight;

[0021] (2) After adding the dried white sac endothelial sheet into a pulverizer to pulverize, pass through a 300-mesh sieve to prepare powder;

[0022] (3) adding the powder prepared by step (2) into the 80% ethanol extractant with a solid-liquid ratio of 1:50;

[0023] (4) refluxing extraction on a constant temperature water bath, refluxing 3 times, each time refluxing for 30 minutes;

[0024] (5) Filtrate with a Buchner funnel under reduced pressure, combine the filtrates, concentrate with a rotary evaporator, and dry to obtain the durian shell extract.

Embodiment 2

[0026] A study on the anti-inflammatory effect of durian shell extract-croton oil-induced mouse ear swelling experiment.

[0027] Get 50 mice and divide them into 5 groups at random, 10 in each group, i.e. normal control group (distilled water 10mg.kg -1 ), positive drug control group (dexamethasone, 1mg.kg -1 ), extract low dose group (100mg.kg -1 ), the extract medium dose group (300mg.kg -1 ), extract high dose group (900mg.kg -1 ). Animals in each group were administered intragastrically once a day for 5 consecutive days, and 1 hour after the last administration, 3 g.L -1 An appropriate amount of croton oil acetone solution was evenly applied to the central part of the right ear margin of the mice to cause ear inflammation in the mice. 30 minutes after the inflammation was induced, the drug was administered once again, and the mice were killed by breaking the cervical spine 4 hours later, and the two ears were cut off, and round ear pieces were punched at the same pos...

Embodiment 3

[0032] A study on the antitussive effect of durian husk extract—a cough test in mice induced by ammonia water.

[0033] Get 50 mice and divide them into 5 groups at random, 10 in each group, i.e. normal control group (distilled water 10mg.kg -1 ), positive drug control group (codeine, 20mg.kg -1 ), extract low dose group (100mg.kg -1 ), the extract medium dose group (300mg.kg -1 ), extract high dose group (900mg.kg -1 ). Animals in each group were administered intragastrically once a day for 3 consecutive days. One hour after the last administration, the mice were placed in a 5L beaker bell jar one by one, and concentrated ammonia water was sprayed at constant pressure to observe the incubation period of mice coughing ( The time from the start of spraying to the first cough of mice), and record the number of times the mice coughed within 2 minutes (typical coughing action: contraction of abdominal muscles or chest shrinkage, while opening the mouth wide, with a coughing so...

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PUM

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Abstract

The invention discloses a preparation method of durio zibethinus murr shell extract. The method comprises the following steps: (1), taking white flesh endocarp of durian fruit skin, cleaning, cutting and drying the white flesh endocarp to constant weight; (2), crushing; (3), adding powder obtained in the step (2) into an ethyl alcohol extractant according to certain ratio of material to solution; (4), performing reflux extraction on a thermostat water bath; (5), performing filtration under reduced pressure through a Buchner funnel, combining filtrate, performing concentration through a rotary evaporator, drying, thereby obtaining the durio zibethinus murr shell extract. The invention further discloses application of the durio zibethinus murr shell extract to preparation of anti-inflammatory, cough suppressant and analgesic drugs, and the preparation of the drugs adopts capsules, tablets, granules, sirup, oral preparation and injection.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a preparation method and application of durian shell extract. Background technique [0002] Durian, also known as shaozi, is a fruit that can be used both as medicine and food. It is rich in minerals and trace elements, and has many health care functions for the human body. Modern studies have shown that durian shell has a variety of beneficial nutrients for the human body, rich in calcium, iron and other trace elements and a variety of amino acids, and has certain medicinal value. Residents in Southeast Asia and South China often use durian shells to make soup, decoct water, etc., to achieve the effects of reducing fire and stagnation, nourishing blood and Qi, nourishing yin, etc., but there are few reports on the pharmacological activity of durian shells. Contents of the invention [0003] An object of the present invention is to provide a preparation method and application of durian...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P29/00A61P11/14
CPCA61K36/185A61K2236/15A61K2236/17A61K2236/333A61K2236/39
Inventor 贺灿炎
Owner 贺灿炎
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