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Neostigmine Bromide powder and preparation method thereof

A technology of bromonostigmine and excipients, which is applied in the field of bromonostigmine powder and its preparation, and can solve the problem of the unknown bromonostigmine powder, and no published research report on bromonostigmine powder, etc. problems, to achieve excellent pharmaceutical properties, suitable apparent specific gravity, and simple preparation process

Inactive Publication Date: 2016-08-17
ANHUI YIXINMING PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] Scholars at home and abroad have not published reports on the development of brominostigmine powder, and there is no known example of actually manufacturing a powder containing brominostigmine

Method used

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  • Neostigmine Bromide powder and preparation method thereof
  • Neostigmine Bromide powder and preparation method thereof
  • Neostigmine Bromide powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The preparation of embodiment 1 bromonestamine powder

[0031] prescription:

[0032]

[0033] Preparation Process:

[0034] ①. Weigh the raw and auxiliary materials of the prescription amount and pass them through 80-120 mesh sieves for later use;

[0035] ②. Stir and mix the sieved raw materials and excipients according to the method of equal increase, and evenly distribute them in polyethylene bottles with tin caps, and pack 100g in each bottle to obtain final product.

Embodiment 2

[0036] The preparation of embodiment 2 bromestrim powder

[0037] prescription:

[0038]

[0039] Preparation Process:

[0040] ①. Weigh the raw and auxiliary materials of the prescription amount and pass them through 80-120 mesh sieves for later use;

[0041] ②. Stir and mix the sieved raw materials and excipients according to the method of equal increase, and evenly distribute them in polyethylene bottles with tin caps, and distribute 500g in each bottle to obtain final product.

Embodiment 3

[0042] The preparation of embodiment 3 bromestrim powder

[0043] prescription:

[0044]

[0045] Preparation Process:

[0046] ①. Weigh the raw and auxiliary materials of the prescription amount and pass them through 80-120 mesh sieves for later use;

[0047] ②. Stir and mix the sieved raw materials and excipients according to the method of equal increase, and evenly distribute them in polyethylene bottles with tin caps, and pack 100g in each bottle to obtain final product.

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Abstract

The invention relates to Neostigmine Bromide powder and a preparation method and belongs to the technical field of pharmaceutical preparations. The powder is composed of, by weight, Neostigmine Bromide and excipient, wherein the weight ratio of the Neostigmine Bromide to the excipient is 0.5: 99.5. The Neostigmine Bromide powder is simple in preparation process, high in bioavailability and low in production cost.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a bromsine powder and a preparation method thereof. The bromcinostigmine powder provided by the invention has excellent pharmaceutical properties. Background technique [0002] Neostigmine bromide is the bromide of neostigmine, which is a cholinesterase inhibitor. It can reversibly inhibit the activity of cholinesterase, slow down the inactivation of acetylcholine, increase the concentration of acetylcholine present at the choline receptor, and enhance and prolong the effect. It can also directly excite the N-choline receptors of striated muscles, and has a more obvious selective excitatory effect on striated muscles. Its main effects are as follows: miosis, bradycardia, increased tension of smooth muscles in the gastrointestinal tract and bronchi, contraction of bladder muscles and uterine muscles, and increased secretion of saliva and sweat. I...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/27A61K47/26A61K47/36A61P21/04A61P1/00A61P1/10A61P7/10
CPCA61K9/146A61K9/145A61K31/27
Inventor 徐奎刘经星
Owner ANHUI YIXINMING PHARMA TECH
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