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Application of compound cercosporamide in preparation of immune enhancer

A technology of immune enhancer, cercospamide, applied in the field of medicinal chemistry

Active Publication Date: 2018-04-20
上海菲禾生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The immunoenhancing or immunomodulatory effects of the small molecule compound cercosporamide have not been reported in the literature so far

Method used

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  • Application of compound cercosporamide in preparation of immune enhancer
  • Application of compound cercosporamide in preparation of immune enhancer
  • Application of compound cercosporamide in preparation of immune enhancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1: Determination of the immunoenhancing activity of the compound cercosporamide:

[0025] 1. Main instruments: MCO-15AC cell incubator, Japan Sanyo Company; SpX-250B-Z biochemical incubator, Shanghai Boxun Industrial Co., Ltd.; 1700 electronic balance, German Sartorius company; SW-CJ-1F ultra-clean work Taiwan, Suzhou Antai Air Technology Co., Ltd.; LD5-2A centrifuge, Beijing Medical Centrifuge Factory; 1-13 centrifuge, Germany SIGMA company; MH-1 micro oscillator, Qilinbeier Instrument Manufacturing Co., Ltd., Haimen, Jiangsu Company; synergy-2SLFPA full-wavelength multi-functional microplate reader, BioTek, USA; XDS-1B biological inverted microscope, Chongqing Optical Instrument Factory.

[0026] 2. Source of experimental animals: female SPF grade C57BL / 6 mice, 6 weeks old, 18-22g, purchased from Shanghai Xipuer-Bikay Experimental Animal Co., Ltd., the experimental animals were fed for one week after purchase, and then the experiment was carried out after adap...

Embodiment 2

[0034]

[0035] Preparation method: mix the active ingredients cercospamide, lactose and cornstarch, moisten evenly with water, sieve the wetted mixture and dry it, then sieve it, add magnesium stearate, then compress the mixture into tablets, each weighing 250mg, The active ingredient ratio is 1%, and the content is 2.5mg.

Embodiment 3

[0037]

[0038] Preparation method: mix the active ingredients cercospamide, lactose and cornstarch, moisten evenly with water, sieve the wetted mixture and dry it, then sieve it, add magnesium stearate, then compress the mixture into tablets, each weighing 250mg, The active ingredient ratio is 4%, and the content is 10mg.

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PUM

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Abstract

The invention provides application of a compound cercosporamide in preparation of an immunoenhancer. The compound has immunoenhancement activity and is used for immunocompromised patients suffering cancers, AIDS, immunodeficiency disorder or aging. The cercosporamide has another name of 4-Dibenzofurancarboxamide. The immunoenhancer comprises an active ingredient cercosporamide and auxiliary materials.

Description

technical field [0001] The invention relates to the field of medicinal chemistry, in particular to the use of cercosporamide in the preparation of an immune enhancer, and the compound has immune enhancer activity in the immune field. Background technique [0002] Discovering new lead compounds from natural products is an important way to create new drugs. Microorganisms are the main source of natural products in nature, and plant endophytic fungi, as an important group, are relatively new research fields. The abundant and diverse secondary metabolites produced by endophytic fungi have important application potential in modern medicine and pesticide industry. Aging and other fields have broad application prospects. A typical example is the discovery of taxol-producing endophytic fungi (Stierle et al., 1993). On the other hand, many new biologically active substances have also been found by relying on plant endophytic fungi, such as Rhinocladiella sp., an endophytic fungus ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/343A61P37/04
CPCA61K31/343
Inventor 陈峰阳叶益萍李晓誉王丽薇章初龙林福呈冯晓晓
Owner 上海菲禾生物科技有限公司
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