Pharmaceutic preparation for thyroid cancer bone metastasis pain and preparation method thereof

A pharmaceutical preparation and technology for thyroid cancer, applied in the field of pharmaceutical preparations and preparations for bone metastases pain from thyroid cancer, to achieve clinical application safety, inhibit diffusion, and prevent aggregation

Inactive Publication Date: 2016-08-31
QINGDAO CHENDA BIOLOGICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are few specific drugs for the pain of bone metastases of thyroid cancer, so further research is necessary to enrich the comprehensive treatment of thyroid cancer

Method used

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  • Pharmaceutic preparation for thyroid cancer bone metastasis pain and preparation method thereof
  • Pharmaceutic preparation for thyroid cancer bone metastasis pain and preparation method thereof
  • Pharmaceutic preparation for thyroid cancer bone metastasis pain and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1 capsule

[0035] Prescription: 12 parts of Jiulongteng, 20 parts of Pigudan, 25 parts of Shuangshen, 12 parts of Rehmannia glutinosa, 8 parts of Epimedium, 9 parts of Rhizoma Cyperi, 18 parts of Niu Ma Teng, 12 parts of Heipi Dieda, 15 parts of Sanyucao 5 parts, 5 parts of iron rod hammer.

[0036] Preparation method: According to the prescription, take Jiulongteng, Bugudan, Shuangshen, Rehmannia glutinosa, Epimedium, Rhizoma Cyperi, Niumateng, Heipi Dieda, Sanyucao, and iron bar hammer and grind them into coarse powder, add 7 times the weight Soak in water for 3-4 hours, decoct for 1-2 hours, filter and collect the filtrate, add water to the filter residue as 4 times the weight of the medicinal material and decoct for 1-1.5 hours, combine the decoction, filter, and concentrate the filtrate under reduced pressure to relative density 1.08 (measured at 60°C), add ethanol to make the alcohol content reach 45%, let it stand for 12 hours, filter, recover the et...

Embodiment 2

[0037] Embodiment 2 capsules

[0038] Prescription: 10 parts of Jiulongteng, 20 parts of Pigudan, 22 parts of Shuangshen, 10 parts of Rehmannia glutinosa, 6 parts of Epimedium, 9 parts of Rhizoma Cyperi, 15 parts of Niu Ma Teng, 12 parts of Heipi Dieda, 13 parts of Sanyucao 6 parts, 6 parts of iron rod hammer.

[0039] Preparation method: According to the prescription, take Jiulongteng, Bugudan, Shuangshen, Rehmannia glutinosa, Epimedium, Rhizoma Cyperi, Niumateng, Heipi Dieda, Sanyucao, and iron stick hammer and grind them into coarse powder, add 6 times the weight Soak in water for 3-4 hours, decoct for 1-2 hours, filter to collect the filtrate, add water to the filter residue 5 times the weight of the medicinal material and decoct for 1-1.5 hours, combine the decoction, filter, and concentrate the filtrate under reduced pressure to relative density 1.08 (measured at 60°C), add ethanol to make the alcohol content reach 47%, let it stand for 12 hours, filter, recover ethanol...

Embodiment 3

[0040] Embodiment 3 capsules

[0041] Prescription: 15 parts of Jiulongteng, 23 parts of Pigudan, 22 parts of Shuangshen, 15 parts of Rehmannia glutinosa, 8 parts of Epimedium, 12 parts of Rhizoma Cyperi, 18 parts of Niu Ma Teng, 12 parts of Heipi Dieda, 15 parts of Sanyucao 8 parts, 8 parts of iron rod hammer.

[0042] Preparation method: According to the prescription, take Jiulongteng, Bugudan, Shuangshen, Rehmannia glutinosa, Epimedium, Rhizoma Cyperi, Niumateng, Heipi Dieda, Sanyucao, and iron stick hammer and grind them into coarse powder, add 8 times the weight Soak in water for 3-4 hours, decoct for 1-2 hours, filter to collect the filtrate, add water to the filter residue to be 3 times the weight of the medicinal material and decoct for 1-1.5 hours, combine the decoction, filter, and concentrate the filtrate under reduced pressure to relative density 1.10 (measured at 60°C), add ethanol to make the alcohol content reach 45%, let it stand for 12 hours, filter, recover ...

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Abstract

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a pharmaceutic preparation for thyroid cancer bone metastasis pain and a preparation method thereof. The pharmaceutic preparation is prepared from the medicinal raw materials of stems of champion bauhinia, common gendarussa herb, roots of lagerflower triplostegia, prepared rehmannia roots, herba epimedii, nutgrass galingale rhizomes, evergreen mucuna roots, stems of manyflower fissistigma, all-grass of ajuga nipponensis makino and pendulous monkshood roots according to a certain proportion. All the medicines are combined for use and have the effects of activating blood circulation, dissipating blood stasis, promoting qi circulation to relieve pain, tonifying the kidney, strengthening bones and clearing and activating the channels and collaterals. The pharmaceutic preparation can effectively adjust the balance of yin and yang, qi and blood and viscera function of organisms, the effects of repairing bone destruction caused by bone metastasis, relieving cancer pain and controlling tumor metastasis are achieved, and the pharmaceutic preparation is safe and reliable in clinic application, good in patient tolerance and worthy of clinic application.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a pharmaceutical preparation for bone metastasis pain of thyroid cancer and a preparation method thereof. Background technique [0002] Thyroid cancer ranks first in both endocrine tumors and head and neck tumors, accounting for about 1% of all solid tumors in the human body. The pathological types are mainly divided into papillary carcinoma, follicular carcinoma, undifferentiated carcinoma, and medullary carcinoma. The main clinical Manifested as neck thyroid lump, pain, hoarseness and difficulty swallowing. In recent years, statistics show that the incidence of thyroid cancer tends to increase, and it has become one of the common malignant tumors. [0003] Clinically, thyroid cancer often has bone metastasis. According to statistics, the incidence rate of bone metastasis in thyroid cancer is 50%. Bone metastasis often leads to pathological fractures, per...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8905A61P35/04A61P29/00
CPCA61K36/185A61K36/19A61K36/296A61K36/48A61K36/486A61K36/53A61K36/714A61K36/804A61K36/8905A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 陈令浩
Owner QINGDAO CHENDA BIOLOGICAL SCI & TECH
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